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Year : 2009  |  Volume : 1  |  Issue : 1  |  Page : 27-31

Synthesis and antimicrobial activity of 2-chloro-6-methylquinoline hydrazone derivatives

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi - 110 062, India

Correspondence Address:
Suresh Kumar
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi - 110 062
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-7406.62683

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Purpose : A series of 2-chloro-6-methylquinoline hydrazones (3a-o) were synthesized by the condensation of substituted acyl hydrazines, semicarbazide, thiosemicarbazide, and INH with 2-chloro-3-formyl-6-methylquinoline in absolute alcohol and were tested for antimicrobial activity. Materials and Methods : The structures of compounds were established using modern analytical technique FT-IR, 1 H and 13 C-NMR, mass spectral data and elemental analysis. All the compounds were evaluated for their antibacterial activity against Escherichia coli (NCTC 10418), Staphylococcus aureus (NCTC 65710), and Pseudomonas aeruginosa (NCTC 10662). The compounds were also tested for antifungal activity aganist Aspergillus niger (MTCC 281), Aspergillus flavus (MTCC 277), Monascus purpureus (MTCC 369) and Penicillium citrinum (NCIM 768) by the cup-plate method. Results : It was observed that maximum antibacterial activity was shown by compounds having the 4-fluoro, 4-chloro, 4-nitro, and 2, 4-dicloro group in the benzoyl ring. Compounds were weakly active against fungal strains. Conclusion : Quinolinyl hydrazone of INH 3o was found to be most active toward the bacterial strains compared to their corresponding benzoyl derivatives.

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