Journal of Pharmacy And Bioallied Sciences
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Year : 2009  |  Volume : 1  |  Issue : 1  |  Page : 32-36

Synthesis and antimicrobial activity of 2-chloroquinoline incorporated pyrazoline derivatives

1 Department of Pharmaceutical Chemistry, Jamia Hamdard (Hamdard University), New Delhi - 110 062, India
2 Pharmaceutical Biotechnology Laboratory, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi - 110 062, India

Correspondence Address:
Suresh Kumar
Department of Pharmaceutical Chemistry, Jamia Hamdard (Hamdard University), New Delhi - 110 062
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-7406.62684

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Purpose : A series of 2-chloroquinoline containing pyrazoline derivatives having 3,4-dichloro/ 3,4-dimethoxy in the phenyl ring were synthesized and screened for their antimicrobial activity against a panel of bacterial and fungal strains. Materials and Methods : The structures of the newly synthesized compounds were established on the basis of spectral data obtained from the FTIR, 1H and 13C-NMR, and mass spectrometry. All the compounds were evaluated for their antibacterial activity against Escherichia coli (NCTC, 10418), Staphylococcus aureus (NCTC, 65710), and Pseudomonas aeruginosa (NCTC, 10662). The compounds were also tested for antifungal activity aganist Aspergillus niger (MTCC, 281), Aspergillus flavus (MTCC, 277), Monascus purpureus (MTCC, 369) and Penicillium citrinum (NCIM, 768) by the cup-plate method. Results : Among the compounds tested, 3,4-dichloro derivatives were comparatively more active in antimicrobial screening with respect to their 3,4-dimethoxy analog. Conclusion : A careful analysis of the antimicrobial activity data of the compounds revealed that compounds 3a, 3b, 3c, and 3e exhibited potent antibacterial

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