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ORIGINAL ARTICLE
Year : 2010  |  Volume : 2  |  Issue : 4  |  Page : 329-332

Neuropharmacological safety evaluation of jigrine: A polyherbal hepatoprotective formulation


1 Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India
2 WHO, 20, Avenue Appia, Geneva 27, Switzerland
3 Department of Pharmacognosy, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India

Correspondence Address:
A K Najmi
Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.72134

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Objective : Jigrine is a herbal hepatoprotective formulation containing aqueous extracts of 14 medicinal plants. Present study was designed to evaluate per se neuropharmacological effects of jigrine in mice. Materials and Methods : Jigrine was evaluated in a number of pharmacological test paradigms, viz. open field arena, actophotometer, hole board, rotarod, traction test, grip strength test, spontaneous alternation behavior, passive avoidance task, and phenobarbital sleeping time. Results and Conclusions : Jigrine pretreatment (1 and 2 ml/kg, p.o.) did not produce any significant effect as compared to normal saline treated animals and was found to be free from any acute undesirable central effects at these two dose levels.


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