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ORIGINAL ARTICLE
Year : 2010  |  Volume : 2  |  Issue : 4  |  Page : 346-349

Evaluation of immunomodulatory potential of ethanolic extract of Roscoea procera rhizomes in mice


1 Department of Pharmacognosy, Radharaman Institute of Pharmaceutical Sciences and Radharaman College of Pharmacy, Ratibad, Bhopal-462044, Madhya Pradesh, India
2 Department of Pharmacology, Radharaman Institute of Pharmaceutical Sciences and Radharaman College of Pharmacy, Ratibad, Bhopal-462044, Madhya Pradesh, India
3 Department of Pharmacology,Gurunanak College of Pharmacy, Nagpur-440001, Maharashtra, India
4 Department of Pharmacognosy, J. L. Chaturvedi College of Pharmacy, Nagpur-440016, Maharashtra, India

Correspondence Address:
Mahesh S Sahu
Department of Pharmacognosy, Radharaman Institute of Pharmaceutical Sciences and Radharaman College of Pharmacy, Ratibad, Bhopal-462044, Madhya Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.72138

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Purpose : The aim of present study was to evaluate immunomodulatory potential of ethanolic extract of Roscoea procera (Zingiberaceae) rhizomes by using delayed-type hypersensitivity (DTH) and carbon clearance method in comparison to standard established immunosuppressant drug, cyclophosphamide (30 mg/kg, i.p.) in mice. Material and Methods : The extract was comprised to acute toxicity (OECD-423 guideline), DTH and carbon clearance method for their immunomodulatory potential. Ethanolic extract of Roscoea procera rhizomes administered orally at doses 300 mg/kg and 600 mg/kg, p.o. to mice. Result and Conclusion : Result of our study revealed that, the foot pat thickness of ethanolic extract group (P<0.05) significantly enhanced the production of circulating antibody titre in response to Sheep red blood cells (SRBC) and phagocytic functions of mononuclear macrophages and non-specific immunity. Result were also supported by serological and haematological tests data. Hence, the present investigation reveals that, ethanolic extract of Roscoea procera rhizomes possesses immunostimulant properties. Further studies to identify the active moieties and elucidation of the mechanism of action are recommended.


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