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 Table of Contents  
Year : 2011  |  Volume : 3  |  Issue : 3  |  Page : 397-402  

Antidiabetic and antihyperlipidemic potential of Abelmoschus esculentus (L.) Moench. in streptozotocin-induced diabetic rats

1 Department of Bioinformatics, Karunya University, Coimbatore, Tamil Nadu, India
2 Department of Pharmacology, KMCH College of Pharmacy, Coimbatore, Tamil Nadu, India

Date of Submission06-Mar-2011
Date of Decision23-Apr-2011
Date of Acceptance20-May-2011
Date of Web Publication3-Sep-2011

Correspondence Address:
K Panneerselvam
Department of Bioinformatics, Karunya University, Coimbatore, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-7406.84447

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Objectives : The present investigation was aimed to study the antidiabetic and antihyperlipidemic potential of Abelmoschus esculentus peel and seed powder (AEPP and AESP) in streptozotocin (STZ)-induced diabetic rats. Materials and Methods : Acute toxicity of AEPP and AESP was studied in rats at 2000 mg/kg dose and diabetes was induced in rats by administration of STZ (60 mg/kg, i.p.). After 14 days of blood glucose stabilization, diabetic rats received AEPP, AESP, and glibenclamide up to 28 days. The blood samples were collected on day 28 to estimate the hemoglobin (Hb), glycosylated hemoglobin (HbA1c), serum glutamate-pyruvate transferase (SGPT), total protein (TP), and lipid profile levels. Results : In acute toxicity study, AESP and AESP did not show any toxicity or death up to a dose of 2000 mg/kg. Therefore, to assess the antidiabetic action, one by fifth and one by tenth dose of both powders were selected. Administration of AEPP and AESP at 100 and 200 mg/kg dose in diabetic rats showed significant (P < 0.001) reduction in blood glucose level and increase in body weight than diabetic control rats. A significant (P < 0.001) increased level of Hb, TP, and decreased level of HbA1c, SGPT were observed after the treatment of both doses of AEPP and AESP. Also, elevated lipid profile levels returned to near normal in diabetic rats after the administration of AEPP and AESP, 100 and 200 mg/kg dose, compared to diabetic control rats. Conclusion : The present study results, first time, support the antidiabetic and antihyperlipidemic potential of A. esculentus peel and seed powder in diabetic rats.

Keywords: Abelmoschus esculentus, antidiabetic, antihyperlipidemic, streptozotocin

How to cite this article:
Sabitha V, Ramachandran S, Naveen K R, Panneerselvam K. Antidiabetic and antihyperlipidemic potential of Abelmoschus esculentus (L.) Moench. in streptozotocin-induced diabetic rats. J Pharm Bioall Sci 2011;3:397-402

How to cite this URL:
Sabitha V, Ramachandran S, Naveen K R, Panneerselvam K. Antidiabetic and antihyperlipidemic potential of Abelmoschus esculentus (L.) Moench. in streptozotocin-induced diabetic rats. J Pharm Bioall Sci [serial online] 2011 [cited 2022 Jun 25];3:397-402. Available from:

Diabetes mellitus is a progressive metabolic disease and it has affected considerable percentage of population throughout the world. Epidemiologic data indicated that 2.8% of the world's population was diabetic in the year 2000 and it may progress to 4.4% of the world's population by 2030. It affects all age groups of people and ethnic groups. [1] In India, statistical analysis revealed that the number of diabetics will rise to 57 million in the year of 2025 compared to 15 million diabetics in 1995. [2] The pathogenesis of both type 1 and type 2 diabetes are different, but hyperglycemia and its associated complications are common in both conditions. [3] In diabetes, elevated level of lipid profile are commonly reported that increases the cardiovascular complications. [4] Presently, diabetes is managed or controlled using pharmacologic agents and nonpharmacologic methods, such as diet and exercise. However, all the pharmacologic agents are not devoid of adverse effects and it triggers scientific community to search for new drugs from all possible sources, including traditional medicines, which might be less toxic when compared to the available drug therapy. [5] Moreover, diabetic complications lead to morbidity and mortality due to multiple defects in its pathophysiology. [6] Presently, research is focused on traditional medicinal plants and herbs, which are used as potential alternative source to treat diabetes with its multiple pharmacologic actions. [7] Several phytoconstituents possessing antidiabetic activity were isolated and studied from many medicinal plants, but still scientists continue their research on medicinal plants to bring good antidiabetic lead or drugs to the healthcare community.

Abelmoschus esculentus (L.) Moench., synonym of okra, known in many English-speaking countries as lady's fingers or gumbo is a flowering plant in the mallow family. [8] It is valued for its edible green seed pods. It is an important vegetable and widely distributed from Africa to Asia, Southern Europe and America. [9] In Asia, okra is typically prepared as traditional medicine as a dietary meal in the treatment of gastric irritations. [10] The plant has a wide range of medicinal value and has been used to control various diseases and disorders. The fiber in okra helps to stabilize blood sugar by regulating the rate at which sugar is absorbed from the intestinal tract. It is a good vegetable for those feeling weak, exhausted, and suffering from depression and it is also used in ulcers, lung inflammation, sore throat as well as irritable bowel. Okra is good for asthma patients and it also normalizes blood sugar and cholesterol levels. [11],[12] Previous studies reported that okra polysaccharide possesses anticomplementary and hypoglycemic activity in normal mice. [13] Also, okra polysaccharide lowers cholesterol level in blood and may prevent cancer by its ability to bind bile acids. [10],[14] Based on the above scientific data, current literature research revealed that lowering of blood glucose and cholesterol levels by okra in diabetic condition is scientifically not yet documented. Therefore, the present study was aimed to investigate antidiabetic and antihyperlipidemic potential of Abelmoschus esculentus (L.) Moench. peel and seed powders in streptozotocin-induced diabetic rats.

   Materials and Methods Top

Plant materials

A. esculentus (L.) Moench was collected from the local farm in Coimbatore, Tamil Nadu, India. The plant material was identified and authenticated by Botanical Survey of India (BSI/SC/5/23/2010-11/Tech.1907), Coimbatore, and the certificate was deposited at our laboratory. The peel and seed was separated and dried under shade. The above plant materials were made as fine powder using mixer and it was stored in an airtight container up to the completion of the study.


Streptozotocin and all other chemicals used in this study are analytical grade and were procured from Himedia Laboratories, Mumbai, India. For the estimation of biochemical parameters, kits were procured from Primal Healthcare Limited, Lab Diagnostic Division, Mumbai, India. The glibenclamide received as gift sample from Orchid Chemicals and Pharmaceuticals Ltd, Chennai, India.

Experimental animals

Male Wistar albino rats (150-200 g) were used to assess antidiabetic activity. Female Wistar rats (150-180 g) were used for the acute toxicity study. The animals were kept and maintained under standard laboratory conditions [temperature (22°C ± 2°C) and humidity (45°C ± 5°C)] with 12:12 h day:night cycle. The animals were fed with standard laboratory diet and allowed to drink water ad libitum. Studies were carried out in accordance with institutional ethical guidelines for the care of laboratory animals of KMCH College of Pharmacy, Coimbatore, India, after the approval (KMCRET/Ph.D/02/2010).

Acute toxicity study

Acute oral toxicity of A. esculentus (L.) Moench. peel and seed powders were determined as per Organization for Economic Cooperation and Development guidelines 423. [15] After the oral administration of AEPP and AESP, animals are observed individually at least once during the first 30 min, periodically during the first 24 h, with special attention given during the first 4 h, and 14 days regularly observed for toxicity determination of AEPP and AESP.

Induction of diabetes

Diabetes was induced in overnight fasted rats by intraperitoneal injection of STZ at a dose of 60 mg/kg body weight in 0.1 M cold citrate buffer (pH 4.5). To prevent the STZ-induced hypoglycemia, rats received 10% dextrose solution after 6 h of STZ administration for next 24 h. Induction of diabetes was verified after 72 h by measuring blood glucose level with strips using glucometer (Accu-Chek® Active, Roche Diagnostic Corporation, Mannheim, Germany) and the animals were allowed 14 days for the stabilization of blood glucose level. [16] On day 14, animals having a blood glucose level higher than 250 mg/dL were considered diabetic and included in the experiments.

Experimental design for antidiabetic activity

Animals were divided into 7 groups and each group consisted of 6 rats. The grouping details are follows:

Group I served as normal control received 0.2% carboxy methyl cellulose (CMC) (5 mL/kg).

Group II served as diabetic control received 0.2% CMC (5 mL/kg).

Groups III and IV served as AEPP 100 and 200 mg/kg treated diabetic rats, respectively.

Groups V and VI served as AESP 100 and 200 mg/kg treated diabetic rats, respectively.

Group VII served as standard drug, glibenclamide (5 mg/kg) treated diabetic rats.

The vehicle (0.2% CMC), AEPP, AESP, and glibenclamide were administered orally to the respective group animals for 28 days. AEPP and AESP were triturated with distilled water and glibenclamide with vehicle just before the oral administration. The fasting body weight, blood glucose level (Accu-Chek® Active, Roche Diagnostic Corporation, Mannheim, Germany) was estimated at the end of every week. [16] On 28 th day, overnight fasted animals received respective treatment and after 1 h all animals were anesthetized with ketamine (100 mg/kg, i.p.); blood sample was collected through retro-orbital plexus puncture and stored in containers with and without disodium ethylene diamine tetra acetate (EDTA) for the biochemical parameters estimation.

Biochemical parameters estimation

The EDTA blood was used to estimate the Hb and HbA1c levels. [17],[18] The serum was separated and its high density lipoprotein (HDL), [19] total cholesterol (TC), [20] triglycerides (TG), [21] glutamate-pyruvate transferase, [22] and total protein [23] were estimated by commercially available kits using semi-autoanalyzer (Photometer 5010 V5+ , Germany). The low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels was calculated by the following equation: [24]

VLDL = Triglycerides/5


Statistical analysis

All the data are expressed as mean ± SEM were evaluated by one-way analysis of variance (ANOVA), followed by Dunnett's test for multiple comparisons using prism Graphpad version 5.0 and values of P < 0.05 were considered as statistically significant.

   Results and Discussion Top

The oral administration of AEPP and AESP did not show any toxicity signs and mortality up to 14 days during acute toxicity study. Both the powders were found to be safe at a dose level of 2000 mg/kg body weight. Therefore, to study the antidiabetic potential of AEPP and AESP, the dose of 100 and 200 mg/kg was selected. In animals, diabetes was induced after the administration of STZ due to its cytotoxicity on pancreatic islet β-cells. [25] The selective toxicity on β-cell, by alkylation of DNA after the STZ injection, produces reduction in insulin level, which leads to alteration of glucose metabolism and utilization thereby causing hyperglycemia. [26] Moreover, intracellular metabolism of STZ produces nitric oxide (NO) free radical and it further initiates the alkylation of β-cells DNA strands and its breaks. [27] In our study, administration of AEPP (100 and 200 mg/kg) and AESP (100 and 200 mg/kg) decreased elevated blood glucose levels significantly (P < 0.001) from first to fourth week compared to diabetic control rats. The AEPP and AESP at a dose 200 mg/kg showed significantly (P < 0.001) more blood glucose reduction than its 100 mg/kg dose. Also, treatment of both the doses of AESP significantly (P < 0.001) produced greater blood glucose reduction when compared to AEPP 100 and 200 mg/kg dose [Table 1]. There are many reports available to support the multiple mechanisms of antidiabetic plants to exert their blood glucose lowering effect, such as inhibition of carbohydrate metabolizing enzymes, enhancement of insulin sensitivity, regeneration of damaged pancreatic islet β-cells, and enhancement of insulin secretion and release. [28] The AEPP and AESP may exert blood glucose lowering activity possibly above mechanism(s) and the antidiabetic activity of both powders was comparable to that of glibenclamide. A significant (P < 0.001) body weight loss was observed after the administration of STZ and it may be due to the degradation of structural proteins. [29] In our study, AEPP and ASEP treated animals showed significant (P < 0.05, P < 0.01, P < 0.001) increase in body weight compared to diabetic control [Figure 1]. This action may be due to the preventive effect of AEPP and AESP on structural protein degradation.
Table 1: Effect of AEPP and AESP on blood glucose level in STZ-induced diabetic rats

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Figure 1: Effect of AEPP and AESP on body weight in STZ-induced diabetic rats.(All data are expressed as mean ± SEM (n=6). aP < 0.001 All groups compared with normal control. bP < 0.001 Diabetic control compared to normal control. cP < 0.05 AEPP 200 mg/kg and glibenclamide 5 mg/kg compared to diabetic control. dP < 0.01 AEPP and AESP 100 mg/kg compared to diabetic control. fP < 0.001 AEPP, AESP (100 and 200 mg/kg) and glibenclamide 5 mg/kg compared to diabetic control)

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Glycosylated hemoglobin is formed through the nonenzymatic binding of circulating glucose to hemoglobin. Higher levels of glucose in the blood contribute to more binding and consequent increased levels of glycosylated hemoglobin. [30] In diabetic condition, decrease in protein synthesis in all tissues and thus the synthesis of hemoglobin is also reduced due to relative deficiency of insulin. [31] HbA1c concentration is associated with diabetic micro, macrovascular complications and risk of death. [30],[32] In the present study, increased level of HbA1c and decreased level of Hb and total protein was observed in diabetic control rats than normal control rats. Total protein level was significantly (P < 0.001) increased after the administration of both doses of AEPP and AESP compared with diabetic control rats. Also, administration of AEPP and AESP significantly (P < 0.001) reduced elevated HbA1c levels and increased the Hb level in diabetic rats [Table 2]. The above actions indicate that AEPP and AESP have potential to prevent the diabetic associated complications.
Table 2: Effect of AEPP and AESP on Hb, HbA1c, total protein, and SGPT in STZ-induced diabetic rats

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The liver damage produced by administration of STZ leads to leakage of SGPT from liver cytosol into the blood stream which in turn increases its level in serum. [29],[33] In the present study, the significant (P < 0.001) increase in serum SGPT was observed in STZ-induced diabetic rats compared to control rats [Table 2]. It represents that liver damage occurred in diabetic rats and oral administration of AEPP and AESP significantly (P < 0.001) reduced the elevated level of SGPT, which supports its protective potential on liver tissue.

Hyperlipidemia was reported as common in adults with diabetes and it is characterized most often by increased triglyceride and reduced HDL cholesterol levels. This is generally observed in both type 1 and type 2 diabetes, representing the defect of insulin action in each, either due to inadequate secretion or resistance. It is well known that hyperlipidemia is accepted as an independent risk factor for cardiovascular disorders (CVD) in diabetic patients. [34] Diabetes induced by STZ in rats significantly (P < 0.001) elevated the TC, TG, LDL, VLDL levels and decreased the HDL levels compared with normal control rats. In the present study, administration of AEPP and AESP at 100 and 200 mg/kg doses to the diabetic rats showed significant (P < 0.001, P < 0.05) reduction in TC, TG, LDL, and VLDL levels than diabetic control rats. The HDL level was increased significantly (P < 0.001) after the treatment of both the dose of AEPP and AESP in diabetic rats compared with diabetic control rats [Table 3]. These actions of AEPP and AESP directly support its ability to reduce hyperlipidemia in diabetes and hence, it may prevent CVD related to diabetes.
Table 3. Effect of AEPP and AESP on lipid profiles in STZ-induced diabetic rats

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   Conclusion Top

The present study, for the first time, confirms that A. esculentus peel and seed possess blood glucose normalization and lipid profiles lowering action in diabetic condition.

   Acknowledgements Top

I thank to Mohammad Akbar, Department of Pharmacology, KMCH College of Pharmacy, Coimbatore for their constant support throughout this research. I thank management, Dr. A. Rajaseakaran, Principal and Mr. K. T. Mani senthil kumar, Head, Department of Pharmacology, KMCH College of Pharmacy, Coimbatore for their given support during the study.

   References Top

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  [Figure 1]

  [Table 1], [Table 2], [Table 3]

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17 Reverse pharmacology of phytoconstituents of food and plant in the management of diabetes: Current status and perspectives
Kalvatala Sudhakar, Vijay Mishra, Varshik Hemani, Arpit Verma, Ankush Jain, Sanjay Jain, R. Narayana Charyulu
Trends in Food Science & Technology. 2021; 110: 594
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18 Efficacy of Coccinia grandis against monosodium glutamate induced hepato-cardiac anomalies by inhibiting NF-kB and caspase 3 mediated signalling in rat model
Arnab Banerjee, Sandip Mukherjee, Bithin Kumar Maji
Human & Experimental Toxicology. 2021; 40(11): 1825
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19 Monosodium glutamate causes hepato-cardiac derangement in male rats
Arnab Banerjee, Sandip Mukherjee, Bithin Kumar Maji
Human & Experimental Toxicology. 2021; : 0960327121
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20 High fat-induced inflammation in vascular endothelium can be improved by Abelmoschus esculentus and metformin via increasing the expressions of miR-146a and miR-155
Luoning Gou, Geng Liu, Rong Ma, Anita Regmi, Tianshu Zeng, Juan Zheng, Xueyu Zhong, Lulu Chen
Nutrition & Metabolism. 2020; 17(1)
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21 Ethnopharmacological review of medicinal plants used to manage diabetes in Morocco
Elhassan Idm’hand, Fouad Msanda, Khalil Cherifi
Clinical Phytoscience. 2020; 6(1)
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22 Role of reduced nitrogen for induction of embryogenic callus induction and regeneration of plantlets in Abelmoschus esculentus L.
Hafiz Muhammad Rizwan, Muhammad Irshad, Bizhu He, Shuang Liu, Xiaocao Lu, Yueting Sun, Dongliang Qiu
South African Journal of Botany. 2020; 130: 300
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23 The Effect of Giving Okra (Abelmoschus esculentus L.) Juice on HDL Levels in the Blood Serum of Wistar Strain Rats Fed High-Fat Feed
Rizqi Nur Alifah, Endah Peniati, Ely Rudyatmi, Ning Setiati
IOP Conference Series: Materials Science and Engineering. 2020; 874(1): 012003
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24 Comparative evaluation of feeding effects of A1 and A2 cow milk derived casein hydrolysates in diabetic model of rats
Neha Thakur, Geeta Chauhan, B.P. Mishra, S.K. Mendiratta, A.K. Pattanaik, Thakur Uttam Singh, M. Karikalan, Somesh Kumar Meshram, Lalita Garg
Journal of Functional Foods. 2020; 75: 104272
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25 The effect of okra ( Abelmoschus esculentus ) on lipid profiles and glycemic indices in Type 2 diabetic adults: Randomized double blinded trials
Arezoo Moradi, Moahammad-Javad Tarrahi, Sara Ghasempour, Mohammadreza Shafiepour, Cain C. T. Clark, Sayyed-Morteza Safavi
Phytotherapy Research. 2020; 34(12): 3325
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26 Molecular characterization of a new bipartite begomovirus that infects okra plants in guerrero, Mexico
Ernestina Valadez-Moctezuma, Samir Samah, Lily Xochilt Zelaya-Molina, Joaquín Bernardo Díaz-Rivera
Journal of Plant Diseases and Protection. 2020; 127(6): 753
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27 Investigation of anti-diabetic plants used among the ethnic communities of Kanpur division, India
Shikha Dixit, Sugandha Tiwari
Journal of Ethnopharmacology. 2020; 253: 112639
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28 Medicinal plants utilized in Thai Traditional Medicine for diabetes treatment: Ethnobotanical surveys, scientific evidence and phytochemicals
Catarina Andrade, Nelson G.M. Gomes, Sutsawat Duangsrisai, Paula B. Andrade, David M. Pereira, Patrícia Valentão
Journal of Ethnopharmacology. 2020; 263: 113177
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29 Characterization of Alginate from Sargassum duplicatum and the Antioxidant Effect of Alginate–Okra Fruit Extracts Combination for Wound Healing on Diabetic Mice
Zulfa Nailul Ilmi, Pugar Arga Cristina Wulandari, Saikhu Akhmad Husen, Dwi Winarni, Mochammad Amin Alamsjah, Khalijah Awang, Marco Vastano, Alessandro Pellis, Duncan Macquarrie, Pratiwi Pudjiastuti
Applied Sciences. 2020; 10(17): 6082
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30 Phenolic Compounds, Antioxidant Activities, and Inhibitory Effects on Digestive Enzymes of Different Cultivars of Okra (Abelmoschus esculentus)
Ding-Tao Wu, Xi-Rui Nie, Dan-Dan Shen, Hong-Yi Li, Li Zhao, Qing Zhang, De-Rong Lin, Wen Qin
Molecules. 2020; 25(6): 1276
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31 Hypoglycemic effect of okra aqueous extract on streptozotocin-induced diabetic rats
Li WU, Minjie WENG, Hengguang ZHENG, Pufu LAI, Baosha TANG, Junchen CHEN, Yibin LI
Food Science and Technology. 2020; 40(4): 972
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32 Understanding Mechanism of Adsorption in the Decolorization of Aqueous Methyl Violet (6B) Solution by Okra Polysaccharides: Experiment and Theory
Mengdan Wang, Qun Gu, Yanlong Luo, Danil Bukhvalov, Xiaofeng Ma, Lijun Zhu, Gefei Li, Zhenyang Luo
ACS Omega. 2019; 4(18): 17880
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33 Analyses of quality and metabolites levels of okra during postharvest senescence by 1 H-high resolution NMR
Juan Liu,Yunfei Yuan,Qixian Wu,Yupeng Zhao,Yueming Jiang,Afiya John,Lingrong Wen,Taotao Li,Qijie Jian,Bao Yang
Postharvest Biology and Technology. 2017; 132: 171
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34 Superimposed effect of ovariectomy on type 2 diabetes mellitus in Wistar rats
Minerva K. Fahmy,Hayam G. Sayyed,Eman A. Abd Elrahim,Rana T.A. Farag
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35 Structure characterisation of polysaccharides in vegetable “okra” and evaluation of hypoglycemic activity
Juan Liu,Yupeng Zhao,Qixian Wu,Afiya John,Yueming Jiang,Jiali Yang,Huiling Liu,Bao Yang
Food Chemistry. 2017;
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36 Comparative evaluation of hypoglycemic and hypolipidemic activity of various extract of Anogeissus latifolia bark in streptozotocin-induced diabetic rats
Subramaniam Ramachandran,Thekkin Kattil Faisal,Jose Anjumary,Aiyalu Rajasekaran,Kuppusamy Asokkumar,Kuppusamy Annadurai,Ramasamy Arivukkarasu,Rajeev Kumar Sharma,Madhira Bhavani Shankar
Journal of Complementary and Integrative Medicine. 2017; 0(0)
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37 Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles
Khalid Ghazanfar,Khan Mubashir,Showkat A Dar,Tazeen Nazir,Iqra Hameed,Bashir A Ganai,Seema Akbar,Akbar Masood
Journal of Complementary and Integrative Medicine. 2017; 0(0)
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38 Biotechnological Advancements and Begomovirus Management in Okra (Abelmoschus esculentus L.): Status and Perspectives
Gyan P. Mishra,Bijendra Singh,Tania Seth,Achuit K. Singh,Jaydeep Halder,Nagendran Krishnan,Shailesh K. Tiwari,Prabhakar M. Singh
Frontiers in Plant Science. 2017; 8
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39 Plants Producing Ribosome-Inactivating Proteins in Traditional Medicine
Letizia Polito,Massimo Bortolotti,Stefania Maiello,Maria Battelli,Andrea Bolognesi
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40 Efficacy of Extracts of African Eggplant and Okra Leaves on Alloxan-Induced Diabetes Mellitus Adult Male Albino Rats
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Pakistan Journal of Nutrition. 2016; 15(6): 551
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41 Herbal Products Use Among Chronic Patients and its Impact on Treatments Safety and Efficacy: A Clinical Survey in the Jordanian Field
Reem A. Issa,Iman A. Basheti
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42 Lectin from Abelmoschus esculentus reduces zymosan-induced temporomandibular joint inflammatory hypernociception in rats via heme oxygenase-1 pathway integrity and tnf-a and il-1ß suppression
Raul Sousa Freitas,Danielle Rocha do Val,Maria Ester Frota Fernandes,Francisco Isaac Fernandes Gomes,José Thalles Jocelino Gomes de Lacerda,Tatiane SantiGadelha,Carlos Alberto de Almeida Gadelha,Vicente de Paulo Teixeira Pinto,Gerardo Cristino-Filho,Karuza Maria Alves Pereira,Gerly Anne de Castro Brito,Mirna Marques Bezerra,Hellíada Vasconcelos Chaves
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43 Preparation of okra-incorporated dhokla and subsequent analysis of nutrition, antioxidant, color, moisture and sensory profile
Sohini Ray,Suman Kumar Saha,Utpal Raychaudhuri,Runu Chakraborty
Journal of Food Measurement and Characterization. 2016;
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44 Target-guided isolation of polar antioxidants from Abelmoschus esculentus (L). Moench by high-speed counter-current chromatography method coupled with wavelength switching and extrusion elution mode
Ranhao Wang,Qi Liu,Zhiliang Wu,Meiling Wang,Xiaoqing Chen
Journal of Separation Science. 2016; 39(20): 3983
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45 Oligomeric proanthocyanidins are the active compounds in Abelmoschus esculentus Moench for its a-amylase and a-glucosidase inhibition activity
Yuyun Lu,Manuela Franziska Demleitner,Lixia Song,Michael Rychlik,Dejian Huang
Journal of Functional Foods. 2016; 20: 463
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46 Abelmoschus esculentus fractions potently inhibited the pathogenic targets associated with diabetic renal epithelial to mesenchymal transition
Chiung-Huei Peng,Charng-Cherng Chyau,Chau-Jong Wang,Huei-Ting Lin,Chien-Ning Huang,Yaw-Bee Ker
Food Funct.. 2016; 7(2): 728
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47 Endophytic Alcaligenes Isolated from Horticultural and Medicinal Crops Promotes Growth in Okra (Abelmoschus esculentus)
Shatrupa Ray,Surendra Singh,B. K. Sarma,H. B. Singh
Journal of Plant Growth Regulation. 2015;
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48 Assessment of factors influencing the tissue culture-independent Agrobacterium-mediated in planta genetic transformation of okra [Abelmoschus esculentus (L.) Moench]
Markandan Manickavasagam,Kondeti Subramanyam,Rajagobalan Ishwarya,Dhandapani Elayaraja,Andy Ganapathi
Plant Cell, Tissue and Organ Culture (PCTOC). 2015; 123(2): 309
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49 Therapeutic effect of okra extract on gestational diabetes mellitus rats induced by streptozotocin
Zhao-Hua Tian,Feng-Tai Miao,Xia Zhang,Qiao-Hong Wang,Na Lei,Li-Chen Guo
Asian Pacific Journal of Tropical Medicine. 2015; 8(12): 1038
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50 Ethnopharmacological knowledge of Shiraz and Fasa in Fars region of Iran for diabetes mellitus
Ahoura Salehi Nowbandegani,Sanaz Kiumarcy,Fateme Rahmani,Maryam Dokouhaki,Sedigheh Khademian,Mohammad Mehdi Zarshenas,Pouya Faridi
Journal of Ethnopharmacology. 2015; 172: 281
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51 Chemical composition, antimicrobial and antioxidant properties of seed oil plants of North-East India: A review
Priyanka Saha,Anupam Das Talukdar,Sanjoy Singh Ningthoujam,Manabendra Dutta Choudhury,Deepa Nath,Lutfun Nahar,Satyajit Dey Sarker,Norazah Basar
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52 Antidiabetic Activity of Artemisia amygdalina Decne in Streptozotocin Induced Diabetic Rats
Khalid Ghazanfar,Bashir A. Ganai,Seema Akbar,Khan Mubashir,Showkat Ahmad Dar,Mohammad Younis Dar,Mudasir A. Tantry
BioMed Research International. 2014; 2014: 1
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53 Phytochemical Analysis, Antioxidant, Antistress, and Nootropic Activities of Aqueous and Methanolic Seed Extracts of Ladies Finger (Abelmoschus esculentusL.) in Mice
Sathish Kumar Doreddula,Srinivasa Reddy Bonam,Durga Prasad Gaddam,Brahma Srinivasa Rao Desu,Nadendla Ramarao,Vijayapandi Pandy
The Scientific World Journal. 2014; 2014: 1
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54 The use of plants in the traditional management of diabetes in Nigeria: Pharmacological and toxicological considerations
Udoamaka F. Ezuruike,Jose M. Prieto
Journal of Ethnopharmacology. 2014; 155(2): 857
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55 Extract of okra lowers blood glucose and serum lipids in high-fat diet induced obese C57BL/6 mice
Shengjie Fan,Yu Zhang,Qinhu Sun,Lijing Yu,Mingxia Li,Bin Zheng,Ximin Wu,Baican Yang,Yiming Li,Cheng Huang
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56 Okra polysaccharide improves metabolic disorders in high-fat diet-induced obese C57BL/6 mice
Shengjie Fan,Lu Guo,Yu Zhang,Qinhu Sun,Baican Yang,Cheng Huang
Molecular Nutrition & Food Research. 2013; 57(11): 2075
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57 Nutraceuticals from fruits and vegetables at a glance: A review
Mahima and Verma, A.K. and Tiwari, R. and Karthik, K. and Chakraborty, S. and Deb, R. and Dhama, K.
Journal of Biological Sciences. 2013; 13(2): 38-47
58 Antidiabetic, antihyperlipidemic and in vivo antioxidant potential of aqueous extract of Anogeissus latifolia bark in type 2 diabetic rats
Ramachandran, S. and Naveen, K.R. and Rajinikanth, B. and Akbar, M. and Rajasekaran, A.
Asian Pacific Journal of Tropical Disease. 2012; 2(SUPPL2): S596-S602
59 Antidiabetic, antihyperlipidemic and in vivo antioxidant potential of aqueous extract of Anogeissus latifolia bark in type 2 diabetic rats
Subramaniam Ramachandran,Koikaramparambil Robert Naveen,Baskaran Rajinikanth,Mohammad Akbar,Aiyalu Rajasekaran
Asian Pacific Journal of Tropical Disease. 2012; 2: S596
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