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Carcinogenic effects of N-nitroso-3-(substituted phenylimino)-indolin-2-one derivatives
Murali Kumarasamy1, Panneerselvam Theivendren2, Rousso Govindarajan3, Scott G Franzblau4, Kirthiga Ramalingam5
1 Department of Chemical Engineering, University of Rovira i Virgili, 26, Av. Paisos Catalans, Tarragona, Spain
2 Department of Pharmaceutical Chemistry, PES's Rajaram and Tarabai Bandekar College of Pharmacy, Faramagudi, Ponda, Goa, India
3 Department of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Jyothi Nagar, Rajiv Gandhi Salai, Thorapakkam, Chennai, Tamil Nadu, India
4 Institute of Tuberculosis Research, University of Illinois, Chicago, USA
5 Bangalore Antibiotics & Biologicals Pvt. Ltd. Salem, Tamilnadu, India
Correspondence Address:
Panneerselvam Theivendren
Department of Pharmaceutical Chemistry, PES's Rajaram and Tarabai Bandekar College of Pharmacy, Faramagudi, Ponda, Goa
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0975-7406.99035
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Aim: A novel series of N-nitroso-3-(substituted phenylimino)-indolin-2-one 3a-h was synthesized and tested for carcinogenic effects. Materials and Methods: The synthesized pyrazole derivatives' chemical structures were proved by means of their infra red (IR), proton nuclear magnetic resonance ( 1 H-NMR), and mass,and confirmed by elemental analyses. The carcinogenic activity was assessed by 3-(4,5dimethyl thiazole-2yl)-2,5-diphenyltetrazoliumbromide (MTT) cell-viability assay. Results: The results show that most of the synthesized compounds exhibit significant carcinogenic activities. Among the synthesized compounds, N-nitroso-3-(2,4-dinitrophenylimino)-indolin-2-one 3h exhibited the most potent carcinogenic activity. Conclusion: The structure-activity relationship (SAR) studies show that the nature as well as the position of the amine are important for deciding the activity profile of the indolin-2-one derivatives, which reiterates the need for further experimental investigations. |
