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Year : 2012  |  Volume : 4  |  Issue : 5  |  Page : 40-41

Enhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach

Department of Pharmaceutics, B. S. Patel Pharmacy College, S.I.T. Campus, Linch, Mehsana, Gujarat, India

Correspondence Address:
Divyesh Thakar
Department of Pharmaceutics, B. S. Patel Pharmacy College, S.I.T. Campus, Linch, Mehsana, Gujarat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-7406.94137

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The objective of this research study was to optimize formulation and process variables affecting characteristic of nanosuspension in bead milling process. In this study, the practically water-insoluble telmisartan was nanoground by using top down method i.e. media milling method. Here the media used is ZnO 2 beads. A variety of surface active agents were tested for their stabilizing effects. Formulation factors evaluated were ratio of polymer to drug, whereas process parameters were milling time and concentration of ZnO 2 beads. Different concentration of stabilizers such as poloxamer 188, poloxamer 407, HPMC E 15, PVP K30 and combination of stabilizers were used for preparation of telmisartan nanosuspension. Responses measured in this study include particle size measurement, particle size distribution and zeta potential.

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