| ORIGINAL ARTICLE |
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| Year : 2013 | Volume
: 5
| Issue : 4 | Page : 309-313 |
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Effect of aqueous extract of Rheum ribes on cisplatin-induced nephrotoxicity in rat
Mousa-Al-Reza Hadjzadeh1, Ziba Rajaei2, Zakieh Keshavarzi3, Mohsen Ghasem Shirazi3, Vahedeh Toosi3
1 Department of Physiology; Neuroscience Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Correspondence Address:
Ziba Rajaei
Department of Physiology, Isfahan University of Medical Sciences, Isfahan
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 24302839 
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Objective: The purpose of the present study was to examine whether Rheum ribes extract prevents cisplatin-induced nephrotoxicity. Materials and Methods: The animals were divided into three groups: Group A considered as control group, group B were treated with cisplatin (3 mg/kg B.W. for 3 alternative days), and group C further to cisplatin received the aqueous extract of Rheum ribes (150 mg/rat). Results: Blood urea nitrogen (BUN) level increased in group B on days 14 and 42 compared to day 0 ( P < 0.001); it was also increased in group B vs. group A on day 14 ( P < 0.001). Rheum ribes extract decreased the serum BUN level on day 14 compared to group B ( P < 0.001). Serum creatinine level in group B had a similar profile as serum BUN level but Rheum ribes had no effect on blood creatinine level. Serum cholesterol level was increased in group B on days 14 and 42 compared to day 0 ( P < 0.001). Also, cholesterol level was significantly increased in group B when compared to group A on day 14 ( P < 0.001). Rheum ribes decreased the blood cholesterol level on day 42 in comparison to group B ( P < 0.001). Serum glucose level was increased in group B on days 14 and 42 vs. day 0 ( P < 0.001). Also, glucose level was significantly increased in group B when compared to group A on day 42 ( P < 0.001). Rheum ribes increased the serum glucose level on days 14 and 42 compared to day 0 ( P < 0.05). Histology of kidneys exposed to cisplatin showed renal injury, but Rheum ribes had no effect on the kidney architecture. Conclusion: Cisplatin-induced nephrotoxicity was confirmed in our study. Although Rheum ribes had some effects on biochemical parameters; its effect on renal histology in injured kidney was insignificant. |
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