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Year : 2014  |  Volume : 6  |  Issue : 2  |  Page : 133-134  

Platelet rich concentrates: A quick healer

1 Department of Conservative Dentistry and Endodontics, Bapuji Dental College and Hospital, Davangere, Karnataka, India
2 Department of Oral and Maxillofacial Pathology, College of Dental Sciences, Davangere, Karnataka, India

Date of Web Publication20-Mar-2014

Correspondence Address:
B S Deepak
Department of Conservative Dentistry and Endodontics, Bapuji Dental College and Hospital, Davangere, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-7406.129180

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How to cite this article:
Deepak B S, Nandini D B. Platelet rich concentrates: A quick healer. J Pharm Bioall Sci 2014;6:133-4

How to cite this URL:
Deepak B S, Nandini D B. Platelet rich concentrates: A quick healer. J Pharm Bioall Sci [serial online] 2014 [cited 2022 Nov 28];6:133-4. Available from:


Platelet rich plasma (PRP) has an extremely broad range of clinical applications in oral and maxillofacial surgery, periodontal surgery, otolaryngology, cardiovascular surgery, burns, wound healing, cosmetic surgery, orthopedic surgery etc., PRP has also been used in combination with mesenchymal stem cells to promote bone regeneration and can also be mixed with fat cells for breast reconstruction, and to correct painful adherent scars. [1] In contrary, some studies even suggest that PRP could even be harmful to tissue repair. [2]

There is still no consensus about the ideal platelet concentration that could optimize the tissue repair process. [2] The mechanism of action of growth factors is very complex, because each growth factor may have a different effect on the signal transduction of bone matrix mineralization. Growth factors may also interact with each other and consequently may form a cascade of different signal proteins with multiple pathways, which will ultimately lead to activation of gene expression followed by protein production. PRP is unique as it acts on multiple signal pathways at the same time. [3]

Platelet rich fibrin (PRF) has been vastly used in dentistry in treatment of periodontal regeneration, bone regeneration, dental implants, dental pulp regeneration. when used in periodontal regeneration PRF had two major benefits firstly the promotion of soft tissue healing as explained by the effect of PRF on progenitor proliferation and migration and secondly the induction of new alveolar bone formation as possibly facilitated by the fibrin mediated effect of PRF on runt-related transcription factor 2 (a key transcription factor associated with osteoblast differentiation) and matrix mineralization and also by the enhancing alkaline phosphatase activity. It also reduces expression of the matrix gla protein (a mineralization inhibitor), preferentially in alveolar bone osteoblast progenitors. [4]

Limitations of PRF are (1) the availability in larger quantity is limited, (2) PRF possesses the circulating immune cells and antigenic molecules that prevent its use as an allogenic material, (3) dehydration of PRF may inactivate the growth factors, (4) contamination of membrane during handling. [5]

   References Top

1.Lucarelli E, Beretta R, Dozza B, Tazzari PL, O'Connel SM, Ricci F, et al. A recently developed bifacial platelet-rich fibrin matrix. Eur Cell Mater 2010;20:13-23.  Back to cited text no. 1
2.Choi BH, Im CJ, Huh JY, Suh JJ, Lee SH. Effect of platelet-rich plasma on bone regeneration in autogenous bone graft. Int J Oral Maxillofac Surg 2004;33:56-9.  Back to cited text no. 2
3.Sandy J, Davies M, Prime S, Farndale R. Signal pathways that transduce growth factor-stimulated mitogenesis in bone cells. Bone 1998;23:17-26.  Back to cited text no. 3
4.Li Q, Pan S, Dangaria SJ, Gopinathan G, Kolokythas A, Chu S, et al. Platelet-rich fibrin promotes periodontal regeneration and enhances alveolar bone augmentation. Biomed Res Int 2013;2013:638043.  Back to cited text no. 4
5.Khiste SV, Tari RN. Platelet-rich fibrin as a biofuel for tissue regeneration. ISRN Biomater 2013, Article ID 627367, p. 1-6.  Back to cited text no. 5


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