Journal of Pharmacy And Bioallied Sciences
Journal of Pharmacy And Bioallied Sciences Login  | Users Online: 523  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size 
    Home | About us | Editorial board | Search | Ahead of print | Current Issue | Past Issues | Instructions | Online submission




 
 Table of Contents  
REVIEW ARTICLE
Year : 2014  |  Volume : 6  |  Issue : 2  |  Page : 69-80  

A review exploring biological activities of hydrazones


Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India

Date of Submission18-Jul-2013
Date of Decision14-Oct-2013
Date of Acceptance31-Oct-2013
Date of Web Publication20-Mar-2014

Correspondence Address:
Mohammad Mumtaz Alam
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.129170

Rights and Permissions
   Abstract 

The development of novel compounds, hydrazones has shown that they possess a wide variety of biological activities viz. antimicrobial, anticonvulsant, antidepressant, anti-inflammatory, analgesic, antiplatelet, antimalarial, anticancer, antifungal, antitubercular, antiviral, cardio protective etc., Hydrazones/azomethines/imines possess-NHN = CH- and constitute an important class of compounds for new drug development. A number of researchers have synthesized and evaluated the biological activities of hydrazones. This review aims at highlighting the diverse biological activities of hydrazones.

Keywords: Azomethine, biological activity, hydrazones


How to cite this article:
Verma G, Marella A, Shaquiquzzaman M, Akhtar M, Ali MR, Alam MM. A review exploring biological activities of hydrazones. J Pharm Bioall Sci 2014;6:69-80

How to cite this URL:
Verma G, Marella A, Shaquiquzzaman M, Akhtar M, Ali MR, Alam MM. A review exploring biological activities of hydrazones. J Pharm Bioall Sci [serial online] 2014 [cited 2022 Jun 25];6:69-80. Available from: https://www.jpbsonline.org/text.asp?2014/6/2/69/129170

Hydrazones, related to ketones and aldehydes belong to a class of organic compounds with the structure, R 1 R 2 C = NNH 2 [1] These compounds possess diverse biological and pharmacological properties such as antimicrobial, anti-inflammatory, analgesic, antifungal, anti-tubercular, antiviral, anticancer, antiplatelet, antimalarial, anticonvulsant, cardio protective, antihelmintic, antiprotozoal, [2] anti-trypanosomal, [3] antischistosomiasis etc. [4] These compounds contain C = N bond, which is conjugated with a lone pair of electrons of the functional nitrogen atom. [5] The nitrogen atoms of the hydrazones are nucleophilic and the carbon atom has both electrophilic and nucleophilic nature. [6] The α-hydrogen of hydrazones is more potent than that of acidic ketones.[7] The combination of hydrazones with other functional group leads to compounds with unique physical and chemical character.[8] Owing to their biological and pharmacological properties, they are considered important for the synthesis of heterocyclic compounds. [9]


   Biological Activity Top


Antimicrobial activity

The emerging bacterial resistance causes a widespread problem for the treatment of various infections. Therefore, the search for antimicrobials is a never-ending task. Now-a-days a number of hydrazone derivatives have been developed and evaluated for their antibacterial activity. Aslan et al., [10] investigated the antibacterial activity of sulfonyl derivatives (1). Certain steroidal hydrazines (2, 3) have been synthesized by Khan [11] which possess in-vitro antibacterial activity. Hydrazones bearing imidazoles (4) have been synthesized and screened for antibacterial activity against numerous bacterial strains by Abdel-Wahab et al.[12] Palekar et al., [13] synthesized different thiazolidinone derivatives (5, 6) using hydrazine hydrate and evaluated them for their in-vitro antibacterial activity. Wang et al., [14] synthesized hydrazone derivatives (7) with significant antibacterial activity. Hydrazone derivatives containing transition metal complex (8) were synthesized and evaluated for antimicrobial activity by Babahan et al.[15] Ozkay et al., [16] synthesized novel benzimidazole derivatives bearing hydrazone moiety (9) with antibacterial activity against different bacterial strains. Khalil et al., [17] synthesized hydrazone derivatives (10) and reported them as potential antibacterial agent. Hydrazone derivatives (11) synthesized by Abdel-Aziz and Mekawey [18] exhibited antibacterial activity with minimum inhibitory concentration (MIC) of 75 μg/mL. Good antibacterial activity of hydrazone derivatives (12) was reported by Bawa et al.[19] Hydrazone derivatives (13), synthesized by Sharma et al., [20] exhibited antibacterial activity against various bacterial strains. Antibacterial activity of certain hydrazone derivatives (14) was reported by Kendall et al.[21] Jubie et al. [22] synthesized hydrazone derivatives (15, 16) and reported them as promising antibacterial agents. Govindasami et al. [23] synthesized and evaluated vanillin related hydrazone derivatives for their antibacterial activity. Compounds 17 and 18 exhibited good activity.

Tuberculosis is a chronic, infectious and most prevalent disease all over the world. It is caused by different strains of the Mycobacterium tuberculosis. Lungs, liver and bones are most susceptible to infection. The activity of the newer agents is mostly tested against virulent H37Rv strain. Kamal et al., [24] synthesized nitroheterocyclic based 1, 2, 4-benzothiadizines (19), which exhibited MIC of 1 μg/mL. Raja et al., [25] synthesized hydrazone derivatives (20) and reported to have MIC of 6.25 μg/mL. Telvekar et al., [26] developed benzofuran-3-carbohydrazide derivatives (21) with good anti-tubercular activity. Hydrazone derivatives (22) synthesized by Gemma et al., [27] exhibited MIC of 6.25 μg/mL. Mahajan et al., [28] synthesized ferrocene-based hydrazone derivatives (23) with significant antitubercular activity. 1H-indole-2,3-dione based hydrazones (24), synthesized by Karali et al., [29] exhibited half maximal inhibitory concentration (IC 50 ) of 7.6 μg/mL. Hydrazones (25), synthesized by Eswaran et al., [30] exhibited a MIC of 6.25 μg/mL. Hydrazones (26, 27) synthesized by Imramovský et al., [31] based on isonicotinoylhydrazide, pyrazinamide, p-aminosalicylic acid, ethambutol, and ciprofloxacin exhibited MIC of 0.78 μg/mL and 3.13 μg/mL respectively. Hearn et al., [32] synthesized anti-tubercular agents (28, 29) which showed MIC of 0.06 μg/mL and 0.20 μg/mL respectively. Nayyar and Jain [33] synthesized disubstituted quinolone based hydrazides (30, 31) with good activity profiles. Turan-Zitouni et al., [34] synthesized thiazolyl hydrazones (32) having anti-tubercular activity with MIC of 2.5 μg/mL. 4-(adamantan-1-yl)-2-substituted quinoline based hydrazones (33) synthesized by Nayyar et al., [35] showed MIC of 1.00 μg/mL. Imramovský et al., [31] synthesized isonicotinyl derivatives (34) with a MIC of 3.13 μg/mL.

Fungal infections are generally observed as superficial or systemic infections in humans, animals as well as plants. The development of antifungal agents has surpassed the development of antibacterials. Secci et al., [36] developed novel Hydrazine derivative (35) and evaluated for in-vitro anti-Candidal activity which exhibited MIC of 0.25 μg/mL. Novel hydrazine thiazole derivatives (36) have been synthesized by Maillard et al., [37] and reported to exhibit anti-Candidal activity with MIC of 0.25 μg/mL. Altintop et al., [38] developed, evaluated novel hydrazone derivatives (37) for in-vitro anti-Candidal activity, and reported to have MIC of 0.05 μg/mL. Hydrazide derivatives (38) synthesized by Telvekar et al., [26] exhibited MIC of <15.62 μg/mL. Chimenti et al.[39] synthesized 2-thiazolylhydrazones (39) and reported to have potential activity against various strains of Candida species. Kocyigit-Kaymakcioglu et al. synthesized and evaluated the antifungal activity of various 3-acetyl-2,5-disubstituted-2,3-dihydro-1, 3, 4-oxadiazoles. Out of these, 4-Fluorobenzoic acid ([5-bromothiophen-2-yl] methylene) hydrazide (40) exhibited highest inhibitory activity against Candida albicans, with MIC value of 125 μg/mL. [40]

Virus is a small infectious agent, which can replicate only inside the living cell of an organism. It infects all types of organisms-humans, animals as well as plants. El-Sabbagh and Rady [41] evaluated the antiviral activity of hydrazone derivatives (41) against hepatitis A virus. Tian et al., [42] synthesized hydrazone derivatives (42, 43) as potential targets of human immunodeficiency virus-1 capsid protein. The half maximal effective concentration (EC 50 ) value of the agents was reported to be 0.21 and 0.17 μM respectively [Figure 1].
Figure 1: Structure of hydrazones reported as antimicrobial agents

Click here to view


Analgesic and anti-inflammatory activity

A number of hydrazone derivatives have been developed to overcome gastrointestinal disturbance and toxicity. Mohamed Eissa et al., [43] developed anthranilic acid derivatives (44) and reported to have significant anti-inflammatory activity. Hydrazones containing 5-methyl-2 benzoxazolinones (45), developed by Salgin-Gökşen et al., [44] were reported to exhibit good analgesic and anti-inflammatory activity. Khan et al., [45] have described the anti-inflammatory activity of hydrazones derivatives of quinoxalinone (46). Rajitha et al., [46] have reported good anti-inflammatory activity of aryl hydrazone derivatives (47). Benzylidene hydrazides (48) with prominent analgesic and anti-inflammatory activity, exhibiting percentage inhibition of 68.66 have been synthesized by Bhandari et al. [47] Gökçe et al., [48] reported the analgesic and anti-inflammatory activity of 6-substituted-3 (2H)-pyridazinone-2-acetyl-2-(p-substituted benzal) hydrazone derivatives (49). Moldovan et al., [49] synthesized various hydrazone derivatives (50) with promising in-vivo anti-inflammatory activity. Kümmerle et al., [50] developed N-acylhydrazone derivatives (51, 52) with ED 50 value of 2.3 and 1.6 mg/kg respectively [Figure 2].
Figure 2: Structure of hydrazones reported as analgesic and anti-inflammatory agents

Click here to view


Anticancer activity

World Health Organization defines cancer as the rapid creation of abnormal cells that grow beyond their usual boundaries and which can invade adjoining parts of the body and spread to other organs. Dandawate et al., [51] developed plumbagin hydrazone derivatives (53) with high activity against breast cancer. Mohareb and Al-Omran [52] synthesized cyanoacetyl hydrazone with pregnanolone derivatives (54) active against multiple cancer cell lines. Aydın et al., [53] synthesized and evaluated flurbiprofen hydrazide derivatives (55) against ovarian and leukemia cancer cell lines. Cui et al., [54] synthesized acylhydrazones (56) and reported to have potent activity against the human promyelocytic leukemic cells (Hl-60). Al-Said et al., [55] synthesized certain compounds (57) and reported to have in-vitro anticancer activity against human breast cancer cell lines MCF7. Liu et al., [56] synthesized, evaluated acetyl hydrazone derivatives (58) for antitumor activity against A549, HCT11b, HepG2, PC-9 and A375 cell lines with an IC 50 value of 4-17 μM. Aryl hydrazone derivatives (59) synthesized by Vogel et al., [57] were reported to have an IC 50 of 6.7 nM against MDA-MB 231 and MCF-7 breast cancer cell lines. Xu et al., [58] screened hydrazone derivatives (60) for kinase inhibition in different cell lines. Benites et al., [59] synthesized hydrazone derivatives (61) and reported them to have significant antiproliferative activity. Hydrazone derivatives reported by Hayakawa et al., [60] (62, 63, 64) exhibited marked PI3 kinase p110 α inhibition. Zheng et al., [61] synthesized hydrazone derivatives (65) with the propensity to act against A549 lung cancer cell lines. Xia et al., [62] synthesized various hydrazones (66) with IC 50 value of 3.33 μM against A549 lung cancer cell lines. Gürsoy et al., [63] reported the anticancer activity of thiazolohydrazides (67) against prostate cancer. Despaigne et al., [64] have described acetylpyridine and benzoylpyridine derived hydrazones (68, 69) as agents against brain tumor [Figure 3].
Figure 3: Structure of hydrazones reported as anticancer agents

Click here to view


Central nervous system (CNS) activity

CNS diseases can affect either brain or the spinal cord resulting in psychological and neurological disorder. Hydrazones are reported to have activity against various disorders of CNS. Salgin-Gökşen et al., [65] synthesized benzylidene hydrazone derivatives (70) and screened them for in-vitro monoamine oxidase inhibitory (MAO-B) activity for Parkinson's disease. Novel 2-Methoxy acyl hydrazone derivatives (71) synthesized by Cutshall et al., [66] were evaluated for inhibition of phosphodiasterase 10A (PDE10A), a PDE responsible for neurological and psychological disorders like schizophrenia. Certain anticonvulsant bishydrazones (72) and hydrazones (73) were developed by Kulandasamy et al.[67] de Oliveira et al., [68] synthesized and evaluated the antidepressant activity of hydrazones (74). Gökhan-Kelekçi et al., [69] synthesized hydrazone derivatives (75, 76), reported their selective MAO-B inhibition and hence useful in the treatment of depression [Figure 4].
Figure 4: Structure of hydrazones reported as CNS agents

Click here to view


Antiprotozoal activity

Protozoa are a diverse group of unicellular eukaryotic organisms affecting human beings, especially in tropical countries. Aryl hydrazone derivatives (77) synthesized by Siddiqui et al., [70] have been evaluated against HM1: IMSS strain of Entamoebica histolytica for anti-amoebic activity and reported to have IC 50 0.13 μM. Gerpe et al., [71] described the anti-Trypanosomal activity of 5-nitrofuran hydrazones (78). Caputto et al., [72] synthesized hydrazine derivatives (79) and reported to have activity against Trypanosoma cruzi (T. cruzi). Carvalho et al., [73] synthesized Cinamic N-acyl hydrazones (80) with good anti-Trypanosomal activity. dos Santos Filho et al., [74] synthesized hydrazone derivatives (81, 82) against T. cruzi. Trypanosomicidal activity of hydrazones (83, 84) has been reported by Porcal et al. [75] Hydrazone derivatives (85) developed by de Aquino et al., [76] have been reported to be useful in infections caused by Toxoplasma gondii. Caputto et al., [77] reported the inhibitory activity of hydrazones (86, 87) against cruzipain-a major cysteine protease of T. cruzi.

Malaria is a widespread infectious disease specifically of the tropics caused by Plasmodium. Antimalarial propensity of hydrazines (88) has been reported by Fattorusso et al.[78] against D10, W2 and 3D7 plasmodial strains with an IC 50 value of 39.2, 79.0 and 11.0 nM respectively. Acharya et al., [79] synthesized hydrazide derivatives (89) with an IC 50 of 160 nM/mL as against 280 nM/mL of the reference chloroquine [Figure 5].
Figure 5: Structure of hydrazones reported as antiprotozoal agents

Click here to view


Cardio protective activity

Cardiovascular disease is a class of diseases that involve the heart and blood vessels. Despite the extensive research, it still remains the major cause of mortalities world-wide. Bi et al., [80] reported hydrazone derivatives (90) to have potent activity against ischemia-reperfusion induced cardiac infarct size. Leal, et al., [81] synthesized acylhydrazone derivative (91) and reported to have high anti-hypertensive activity.

Antiplatelet activity

Antiplatelet drugs are the agents which decrease platelet aggregation and inhibit thrombus formation. Mashayekhi et al., [82] demonstrated the antiplatelet activity of hydrazone derivatives (92) containing indole moiety. Hydrazone derivatives (93, 94) synthesized by Lima et al., [83] were reported to inhibit platelet aggregation induced by collagen and thrombin [Figure 6].
Figure 6: Structure of hydrazones reported as cardioprotective and antiplatelet agents

Click here to view



   Conclusion Top


The present review highlights the use of hydrazones as lead for the development of newer compounds. Biological activities of hydrazones include antibacterial, anticonvulsant, analgesic, anti-inflammatory, cardio protective, antiplatelet, anticancer etc., With proper designing, synthesis and structure activity relationship, a number of compounds can be developed with diverse biological activities.

 
   References Top

1.Uppal G, Bala S, Kamboj S, Saini M. Therapeutic review exploring antimicrobial potential of hydrazones as promising lead. Der Pharma Chem 2011;3:250-68.  Back to cited text no. 1
    
2.Rollas S, Küçükgüzel SG. Biological activities of hydrazone derivatives. Molecules 2007;12:1910-39.  Back to cited text no. 2
    
3.Narang R, Narasimhan B, Sharma S. A review on biological activities and chemical synthesis of hydrazide derivatives. Curr Med Chem 2012;19:569-612.  Back to cited text no. 3
    
4.Negi VJ, Sharma AK, Negi JS, Ra V. Biological activities of hydrazone derivatives in the new millennium. Int J Pharm Chem 2012;4:100-9.  Back to cited text no. 4
    
5.Corey EJ, Enders D. Applications of N, N-dimethylhydrazones to synthesis. Use in efficient, positionally and stereochemically selective C=C bond formation, oxidative hydrolysis of carbonyl compounds. Tetrahedron Lett 1976;17:3-6.  Back to cited text no. 5
    
6.Corey EJ, Enders D. Synthetic routes to polyfunctional molecules via metalated N, N-dimethylhydrazones. Tetrahedron Lett 1976;17:11-4.  Back to cited text no. 6
    
7.Belskaya NP, Dehaen W, Bakulev VA. Synthesis and properties of hydrazones bearing amide, thioamide and amidine functions. Arch Org Chem 2010;1:275-332.  Back to cited text no. 7
    
8.Xavier AJ, Thakur M, Marie JM. Synthesis and spectral characterisation of hydrazone based 14-membered octaaza macrocyclic Ni (II) complexes. J Chem Pharm Res 2012;4:986-90.  Back to cited text no. 8
    
9.Banerjee S, Mondal S, Chakraborty W, Sen S, Gachhui R, Butcher RJ, et al. Syntheses, X-ray crystal structures, DNA binding, oxidative cleavage and antimicrobial studies of two Cu (II) hydrazone complees. Polyhedron 2009;28:2785-93.  Back to cited text no. 9
    
10.Aslan HG, Özcan S, Karacan N. The antibacterial activity of some sulfonamides and sulfonyl hydrazones, and 2D-QSAR study of a series of sulfonyl hydrazones. Spectrochim Acta A Mol Biomol Spectrosc 2012;98:329-36.  Back to cited text no. 10
    
11.Khan SA. Synthesis, characterization and in vitro antibacterial activity of new steroidal 5-en-3-oxazolo and thiazoloquinoxaline. Eur J Med Chem 2008;43:2040-4.  Back to cited text no. 11
    
12.Abdel-Wahab BF, Awad GE, Badria FA. Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles. Eur J Med Chem 2011;46:1505-11.  Back to cited text no. 12
    
13.Palekar VS, Damle AJ, Shukla SR. Synthesis and antibacterial activity of some novel bis-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and bis-4-thiazolidinone derivatives from terephthalic dihydrazide. Eur J Med Chem 2009;44:5112-6.  Back to cited text no. 13
    
14.Wang Y, Yang L, Liu Z. Synthesis and antibacterial activity of 5-(2-Hydroxyphenyl)-1,3,4-thiadiazol-2-yl-sulfanyl acetyl hydrazones. Chin J Org Chem 2013;33:154-8.  Back to cited text no. 14
    
15.Babahan I, Coban EP, Biyik H. Synthesis, characterisation and antimicrobial activities of vicdioxime derivatives containing heteroaromatic hydrazone groups and their metal complexes. Maejo Int J Sci Technol 2013;7:26-41.  Back to cited text no. 15
    
16.Ozkay Y, Tunali Y, Karaca H, Iþikdað I. Antimicrobial activity and a SAR study of some novel benzimidazole derivatives bearing hydrazone moiety. Eur J Med Chem 2010;45:3293-8.  Back to cited text no. 16
    
17.Khalil AM, Berghot MA, Gouda MA. Synthesis and antibacterial activity of some new heterocycles incorporating phthalazine. Eur J Med Chem 2009;44:4448-54.  Back to cited text no. 17
    
18.Abdel-Aziz HA, Mekawey AA. Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. Eur J Med Chem 2009;44:4985-97.  Back to cited text no. 18
    
19.Bawa S, Kumar S, Drabu S, Kumar R. Synthesis and antimicrobial activity of 2-chloro-6-methylquonoline hydrazone derivatives. J Pharm Bioallied Sci 2009;1:27-31.  Back to cited text no. 19
    
20.Sharma RN, Sharma KP, Dikshit SN. Synthesis, characterization and biological activities of some new hypophosphorous adducts of acid hydrazones derived from 2-[(N-benzoyl) 2, 3 dichloroanilido] acetohydrazide. Arch Appl Sci Res 2011;3:415-24.  Back to cited text no. 20
    
21.Kendall JD, Rewcastle GW, Frederick R, Mawson C, Denny WA, Marshall ES, et al. Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors. Bioorg Med Chem 2007;15:7677-87.  Back to cited text no. 21
    
22.Jubie S, Meena S, Ramaseshu KV, Jawahar N, Vijayakumar S. Synthesis and biological evaluation of some hydrazones and carbazones of indane 1,3-dione. Indian J Chem 2010;49B: 1261-3.  Back to cited text no. 22
    
23.Govindasami T, Pandey A, Palanivelu N, Pandey A. Synthesis, characterization, and antibacterial activity of biologically important vanillin related hydrazone derivatives. Int J Org Chem 2011;1:71-7.  Back to cited text no. 23
    
24.Kamal A, Ahmed SK, Reddy KS, Khan MN, Shetty RV, Siddhardha B, et al. Anti-tubercular agents. Part IV: Synthesis and antimycobacterial evaluation of nitroheterocyclic-based 1,2,4-benzothiadiazines. Bioorg Med Chem Lett 2007;17:5419-22.  Back to cited text no. 24
    
25.Raja AS, Agarwal AK, Mahajan N, Pandeya SN, Ananthan S. Antibacterial and antitubercular activity of some diphenyl hydrazones and semicarbazones. Indian J Chem 2010;49B: 1384-8.  Back to cited text no. 25
    
26.Telvekar VN, Belubbi A, Bairwa VK, Satardekar K. Novel N'- benzylidene benzofuran-3-carbohydrazide derivatives as antitubercular and antifungal agents. Bioorg Med Chem Lett 2012;22:2343-6.  Back to cited text no. 26
    
27.Gemma S, Savini L, Altarelli M, Tripaldi P, Chiasserini L, Coccone SS, et al. Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies. Bioorg Med Chem 2009;17:6063-72.  Back to cited text no. 27
    
28.Mahajan A, Kremer L, Louw S, Guérardel Y, Chibale K, Biot C. Synthesis and in vitro antitubercular activity of ferrocene-based hydrazones. Bioorg Med Chem Lett 2011;21:2866-8.  Back to cited text no. 28
    
29.Karali N, Gürsoy A, Kandemirli F, Shvets N, Kaynak FB, Ozbey S, et al. Synthesis and structure-antituberculosis activity relationship of 1H-indole-2,3-dione derivatives. Bioorg Med Chem 2007;15:5888-904.  Back to cited text no. 29
    
30.Eswaran S, Adhikari AV, Chowdhury IH, Pal NK, Thomas KD. New quinoline derivatives: Synthesis and investigation of antibacterial and antituberculosis properties. Eur J Med Chem 2010;45:3374-83.  Back to cited text no. 30
    
31.Imramovský A, Polanc S, Vinsová J, Kocevar M, Jampílek J, Recková Z, et al. A new modification of anti-tubercular active molecules. Bioorg Med Chem 2007;15:2551-9.  Back to cited text no. 31
    
32.Hearn MJ, Cynamon MH, Chen MF, Coppins R, Davis J, Joo-On Kang H, et al. Preparation and antitubercular activities in vitro and in vivo of novel Schiff bases of isoniazid. Eur J Med Chem 2009;44:4169-78.  Back to cited text no. 32
    
33.Nayyar A, Jain R. Synthesis and anti-tuberculosis activity of 2,4-disubstituted quinolones. Indian J Chem 2008;47B: 117-28.  Back to cited text no. 33
    
34.Turan-Zitouni G, Ozdemir A, Kaplancikli ZA, Benkli K, Chevallet P, Akalin G. Synthesis and antituberculosis activity of new thiazolylhydrazone derivatives. Eur J Med Chem 2008;43:981-5.  Back to cited text no. 34
    
35.Nayyar A, Monga V, Malde A, Coutinho E, Jain R. Synthesis, anti-tuberculosis activity, and 3D-QSAR study of 4-(adamantan-1-yl)-2-substituted quinolines. Bioorg Med Chem 2007;15:626-40.  Back to cited text no. 35
    
36.Secci D, Bizzarri B, Bolasco A, Carradori S, D'Ascenzio M, Rivanera D, et al. Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl) thiazol-2-yl) hydrazine derivatives. Eur J Med Chem 2012;53:246-53.  Back to cited text no. 36
    
37.Maillard LT, Bertout S, Quinonéro O, Akalin G, Turan-Zitouni G, Fulcrand P, et al. Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives. Bioorg Med Chem Lett 2013;23:1803-7.  Back to cited text no. 37
    
38.Altýntop MD, Özdemir A, Turan-Zitouni G, Ilgýn S, Atlý Ö, Ýþcan G, et al. Synthesis and biological evaluation of some hydrazone derivatives as new anticandidal and anticancer agents. Eur J Med Chem 2012;58:299-307.  Back to cited text no. 38
    
39.Chimenti F, Bizzarri B, Maccioni E, Secci D, Bolasco A, Fioravanti R, et al. Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. Bioorg Med Chem Lett 2007;17:4635-40.  Back to cited text no. 39
    
40.Kocyigit-Kaymakcioglu B, Oruc-Emre EE, Unsalan S, Tabanca N, Khan SI, Wedge DE, et al. Synthesis and biological activity of hydrazide-hydrazones and their corresponding 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazoles. Med Chem Res 2012;21:3499-508.  Back to cited text no. 40
    
41.el-Sabbagh OI, Rady HM. Synthesis of new acridines and hydrazones derived from cyclic beta-diketone for cytotoxic and antiviral evaluation. Eur J Med Chem 2009;44:3680-6.  Back to cited text no. 41
    
42.Tian B, He M, Tang S, Hewlett I, Tan Z, Li J, et al. Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein. Bioorg Med Chem Lett 2009;19:2162-7.  Back to cited text no. 42
    
43.Mohamed Eissa AA, Soliman GA, Khataibeh MH. Design, synthesis and anti-inflammatory activity of structurally simple anthranilic acid congeners devoid of ulcerogenic side effects. Chem Pharm Bull (Tokyo) 2012;60:1290-300.  Back to cited text no. 43
    
44.Salgin-Gökºen U, Gökhan-Kelekçi N, Göktaº O, Köysal Y, Kiliç E, Iºik S, et al. 1-Acylthiosemicarbazides, 1,2,4-triazole-5 (4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2- benzoxazolinones: Synthesis, analgesic-anti-inflammatory and antimicrobial activities. Bioorg Med Chem 2007;15:5738-51.  Back to cited text no. 44
    
45.Khan KM, Khan M, Ali M, Taha M, Rasheed S, Perveen S, et al. Synthesis of bis-Schiff bases of isatins and their antiglycation activity. Bioorg Med Chem 2009;17:7795-801.  Back to cited text no. 45
    
46.Rajitha G, Saideepa N, Praneetha P. Synthesis and evaluation of N-(α-benzamidocinnamoyl) aryl hydrazone derivative for anti-inflammatory and antioxidant activities. Indian J Chem 2011;50B: 729-33.  Back to cited text no. 46
    
47.Bhandari SV, Bothara KG, Raut MK, Patil AA, Sarkate AP, Mokale VJ. Design, synthesis and evaluation of antiinflammatory, analgesic and ulcerogenicity studies of novel S-substituted phenacyl-1,3,4-oxadiazole-2-thiol and Schiff bases of diclofenac acid as nonulcerogenic derivatives. Bioorg Med Chem 2008;16:1822-31.  Back to cited text no. 47
    
48.Gökçe M, Utku S, Küpeli E. Synthesis and analgesic and anti-inflammatory activities 6-substituted-3 (2H)-pyridazinone-2-acetyl-2-(p-substituted/nonsubstituted benzal) hydrazone derivatives. Eur J Med Chem 2009;44:3760-4.  Back to cited text no. 48
    
49.Moldovan CM, Oniga O, Pârvu A, Tiperciuc B, Verite P, Pîrna¢u A, et al. Synthesis and anti-inflammatory evaluation of some new acyl-hydrazones bearing 2-aryl-thiazole. Eur J Med Chem 2011;46:526-34.  Back to cited text no. 49
    
50.Kümmerle AE, Vieira MM, Schmitt M, Miranda AL, Fraga CA, Bourguignon JJ, et al. Design, synthesis and analgesic properties of novel conformationally-restricted N-acylhydrazones (NAH). Bioorg Med Chem Lett 2009;19:4963-6.  Back to cited text no. 50
    
51.Dandawate P, Khan E, Padhye S, Gaba H, Sinha S, Deshpande J, et al. Synthesis, characterization, molecular docking and cytotoxic activity of novel plumbagin hydrazones against breast cancer cells. Bioorg Med Chem Lett 2012;22:3104-8.  Back to cited text no. 51
    
52.Mohareb RM, Al-Omran F. Reaction of pregnenolone with cyanoacetylhydrazine: Novel synthesis of hydrazide-hydrazone, pyrazole, pyridine, thiazole, thiophene derivatives and their cytotoxicity evaluations. Steroids 2012;77:1551-9.  Back to cited text no. 52
    
53.Aydýn S, Kaushik-Basu N, Arora P, Basu A, Nichols BD, Talele TT, et al. Microwave assisted synthesis of some novel flurbiprofen hydrazidehydrazones as anti-HCV NS5B and anti-cancer agents. Marmara Pharm J 2013;17:26-34.  Back to cited text no. 53
    
54.Cui Z, Li Y, Ling Y, Huang J, Cui J, Wang R, et al. New class of potent antitumor acylhydrazone derivatives containing furan. Eur J Med Chem 2010;45:5576-84.  Back to cited text no. 54
    
55.Al-Said MS, Bashandy MS, Al-Qasoumi SI, Ghorab MM. Anti-breast cancer activity of some novel 1,2-dihydropyridine, thiophene and thiazole derivatives. Eur J Med Chem 2011;46:137-41.  Back to cited text no. 55
    
56.Liu T, Sun C, Xing X, Jing L, Tan R, Luo Y, et al. Synthesis and evaluation of 2-[2-(phenylthiomethyl)-1H-benzo[d] imidazol-1-yl) acetohydrazide derivatives as antitumor agents. Bioorg Med Chem Lett 2012;22:3122-5.  Back to cited text no. 56
    
57.Vogel S, Kaufmann D, Pojarová M, Müller C, Pfaller T, Kühne S, et al. Aroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents. Bioorg Med Chem 2008;16:6436-47.  Back to cited text no. 57
    
58.Xu G, Abad MC, Connolly PJ, Neeper MP, Struble GT, Springer BA, et al. 4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors. Bioorg Med Chem Lett 2008;18:4615-9.  Back to cited text no. 58
    
59.Benites J, Valderrama JA, Rivera F, Rojo L, Campos N, Pedro M, et al. Studies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines. Bioorg Med Chem 2008;16:862-8.  Back to cited text no. 59
    
60.Hayakawa M, Kawaguchi K, Kaizawa H, Koizumi T, Ohishi T, Yamano M, et al. Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a] pyridines as novel PI3 kinase p110alpha inhibitors. Bioorg Med Chem 2007;15:5837-44.  Back to cited text no. 60
    
61.Zheng LW, Wu LL, Zhao BX, Dong WL, Miao JY. Synthesis of novel substituted pyrazole-5-carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer cells. Bioorg Med Chem 2009;17:1957-62.  Back to cited text no. 61
    
62.Xia Y, Fan CD, Zhao BX, Zhao J, Shin DS, Miao JY. Synthesis and structure-activity relationships of novel 1-arylmethyl-3-aryl- 1H-pyrazole-5-carbohydrazide hydrazone derivatives as potential agents against A549 lung cancer cells. Eur J Med Chem 2008;43:2347-53.  Back to cited text no. 62
    
63.Gürsoy E, Güzeldemirci NU. Synthesis and primary cytotoxicity evaluation of new imidazo[2,1-b] thiazole derivatives. Eur J Med Chem 2007;42:320-6.  Back to cited text no. 63
    
64.Despaigne AA, Parrilha GL, Izidoro JB, da Costa PR, dos Santos RG, Piro OE, et al. 2-Acetylpyridine-and 2-benzoylpyridine-derived hydrazones and their gallium (III) complexes are highly cytotoxic to glioma cells. Eur J Med Chem 2012;50:163-72.  Back to cited text no. 64
    
65.Salgin-Gökºen U, Gökhan-Kelekçi N, Yabanoglu-Çiftci S, Yelekçi K, Uçar G. Synthesis, molecular modeling, and in vitro screening of monoamine oxidase inhibitory activities of some novel hydrazone derivatives. J Neural Transm 2013;120:883-91.  Back to cited text no. 65
    
66.Cutshall NS, Onrust R, Rohde A, Gragerov S, Hamilton L, Harbol K, et al. Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia. Bioorg Med Chem Lett 2012;22:5595-9.  Back to cited text no. 66
    
67.Kulandasamy R, Adhikari AV, Stables JP. A new class of anticonvulsants possessing 6 Hz activity: 3,4-dialkyloxy thiophene bishydrazones. Eur J Med Chem 2009;44:4376-84.  Back to cited text no. 67
    
68.de Oliveira KN, Costa P, Santin JR, Mazzambani L, Bürger C, Mora C, et al. Synthesis and antidepressant-like activity evaluation of sulphonamides and sulphonyl-hydrazones. Bioorg Med Chem 2011;19:4295-306.  Back to cited text no. 68
    
69.Gökhan-Kelekçi N, Koyunoðlu S, Yabanoðlu S, Yelekçi K, Ozgen O, Uçar G, et al. New pyrazoline bearing 4 (3H)-quinazolinone inhibitors of monoamine oxidase: Synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. Bioorg Med Chem 2009;17:675-89.  Back to cited text no. 69
    
70.Siddiqui SM, Salahuddin A, Azam A. Synthesis, characterization and antiamoebic activity of some hydrazone and azole derivatives bearing pyridyl moiety as a promising heterocyclic scaffold. Eur J Med Chem 2012;49:411-6.  Back to cited text no. 70
    
71.Gerpe A, Alvarez G, Benítez D, Boiani L, Quiroga M, Hernández P, et al. 5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene. Bioorg Med Chem 2009;17:7500-9.  Back to cited text no. 71
    
72.Caputto ME, Fabian LE, Benítez D, Merlino A, Ríos N, Cerecetto H, et al. Thiosemicarbazones derived from 1-indanones as new anti-Trypanosoma cruzi agents. Bioorg Med Chem 2011;19:6818-26.  Back to cited text no. 72
    
73.Carvalho SA, Feitosa LO, Soares M, Costa TE, Henriques MG, Salomão K, et al. Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents. Eur J Med Chem 2012;54:512-21.  Back to cited text no. 73
    
74.dos Santos Filho JM, Leite AC, de Oliveira BG, Moreira DR, Lima MS, Soares MB, et al. Design, synthesis and cruzain docking of 3-(4-substituted-aryl)-1,2,4-oxadiazole-N-acylhydrazones as anti-Trypanosoma cruzi agents. Bioorg Med Chem 2009;17:6682-91.  Back to cited text no. 74
    
75.Porcal W, Hernández P, Boiani L, Boiani M, Ferreira A, Chidichimo A, et al. New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle. Bioorg Med Chem 2008;16:6995-7004.  Back to cited text no. 75
    
76.de Aquino TM, Liesen AP, da Silva RE, Lima VT, Carvalho CS, de Faria AR, et al. Synthesis, anti-Toxoplasma gondii and antimicrobial activities of benzaldehyde 4-phenyl-3-thiosemicarbazones and 2-[(phenylmethylene) hydrazono]-4-oxo-3-phenyl-5-thiazolidineacetic acids. Bioorg Med Chem 2008;16:446-56.  Back to cited text no. 76
    
77.Caputto ME, Ciccarelli A, Frank F, Moglioni AG, Moltrasio GY, Vega D, et al. Synthesis and biological evaluation of some novel 1-indanone thiazolylhydrazone derivatives as anti-Trypanosoma cruzi agents. Eur J Med Chem 2012;55:155-63.  Back to cited text no. 77
    
78.Fattorusso C, Campiani G, Kukreja G, Persico M, Butini S, Romano MP, et al. Design, synthesis, and structure-activity relationship studies of 4-quinolinyl-and 9-acrydinylhydrazones as potent antimalarial agents. J Med Chem 2008;51:1333-43.  Back to cited text no. 78
    
79.Acharya BN, Saraswat D, Kaushik MP. Pharmacophore based discovery of potential antimalarial agent targeting haem detoxification pathway. Eur J Med Chem 2008;43:2840-52.  Back to cited text no. 79
    
80.Bi W, Cai J, Liu S, Baudy-Floc'h M, Bi L. Design, synthesis and cardioprotective effect of a new class of dual-acting agents: Phenolic tetrahydro-beta-carboline RGD peptidomimetic conjugates. Bioorg Med Chem 2007;15:6909-19.  Back to cited text no. 80
    
81.Leal CM, Pereira SL, Kümmerle AE, Leal DM, Tesch R, de Sant'Anna CM, et al. Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor. Eur J Med Chem 2012;55:49-57.  Back to cited text no. 81
    
82.Mashayekhi V, Haj Mohammad Ebrahim Tehrani K, Amidi S, Kobarfard F. Synthesis of novel indole hydrazone derivatives and evaluation of their antiplatelet aggregation activity. Chem Pharm Bull (Tokyo) 2013;61:144-50.  Back to cited text no. 82
    
83.Lima LM, Frattani FS, Dos Santos JL, Castro HC, Fraga CA, Zingali RB, et al. Synthesis and anti-platelet activity of novel arylsulfonate - Acylhydrazone derivatives, designed as antithrombotic candidates. Eur J Med Chem 2008;43:348-56.  Back to cited text no. 83
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6]


This article has been cited by
1 Spectral studies, thermal investigations, and anticancer activity of some divalent metal complexes derived from 2-(4-bromophenylamino)acetohydrazide ligand
Esam M. Emara, Wael A. El-Sayed, Abeer S. A. Khalaf-Allah, Fahad M. Alminderej, Yasser K. Abdel-Monem, Ahmed A. Abd-Rabou
Applied Organometallic Chemistry. 2022;
[Pubmed] | [DOI]
2 Synthesis and Antiviral Activity of Modified 5a-Steroids
N. Sh. Nadaraia, N. N. Barbakadze, M. L. Kakhabrishvili, K. G. Mulkidzhanyan, M. Z. Getia
Chemistry of Natural Compounds. 2022;
[Pubmed] | [DOI]
3 Design, synthesis of new novel quinoxalin-2(1H)-one derivatives incorporating hydrazone, hydrazine, and pyrazole moieties as antimicrobial potential with in-silico ADME and molecular docking simulation
Ahmed Ragab, Doaa M. Elsisi, Ola A. Abu Ali, Moustafa S. Abusaif, Ahmed A. Askar, Awatef A. Farag, Yousry A. Ammar
Arabian Journal of Chemistry. 2022; 15(1): 103497
[Pubmed] | [DOI]
4 Synthesis, biological evaluation and docking studies of methylene bearing cyanopyrimidine derivatives possessing a hydrazone moiety as potent Lysine specific demethylase-1 (LSD1) inhibitors: A promising anticancer agents
Sharba Tasneem, Khursheed A. Sheikh, Md Naematullah, M. Mumtaz Alam, Farah Khan, Manika Garg, Mohd. Amir, Mymoona Akhter, Shaista Amin, Anzarul Haque, Mohammad Shaquiquzzaman
Bioorganic Chemistry. 2022; 126: 105885
[Pubmed] | [DOI]
5 Organocatalytic Oxidative C–H Amination of Aldehyde Hydrazones with Azoles at Ambient Temperature
Asim Kumar Ghosh, Sukanya Neogi, Krishna Kanta Das, Alakananda Hajra
The Journal of Organic Chemistry. 2022;
[Pubmed] | [DOI]
6 Accessing Illusive E Isomers of a-Ester Hydrazones via Visible-Light-Induced Pd-Catalyzed Heck-Type Alkylation
Nikita Kvasovs, Vladimir Gevorgyan
Organic Letters. 2022;
[Pubmed] | [DOI]
7 Antimalarial Activity of Highly Coordinative Fused Heterocycles Targeting ß-Hematin Crystallization
María E. Acosta, Lourdes Gotopo, Neira Gamboa, Juan R. Rodrigues, Genesis C. Henriques, Gustavo Cabrera, Angel H. Romero
ACS Omega. 2022;
[Pubmed] | [DOI]
8 Evaluation of antioxidant and cytotoxic properties of phenolic N -acylhydrazones: structure–activity relationship
Jovica Brankovic, Nevena Milivojevic, Vesna Milovanovic, Dušica Simijonovic, Zorica D. Petrovic, Zoran Markovic, Dragana S. Šeklic, Marko N. Živanovic, Milena D. Vukic, Vladimir P. Petrovic
Royal Society Open Science. 2022; 9(6)
[Pubmed] | [DOI]
9 Hydrazone analogues with promising antibacterial profiles: Synthesis, morphology, in vitro and in silico approaches
M. Nabizadeh, M.R. Naimi-Jamal, M. Rohani, P. Azerang, A. Tahghighi
Letters in Applied Microbiology. 2022;
[Pubmed] | [DOI]
10 Synthesis and Antimicrobial Activity of Novel Hydrazone and 1,2,4-Triazole-3-thione Derivatives
A. N. Yankin, N. V. Nosova, V. V. Novikova, V. L. Gein
Russian Journal of General Chemistry. 2022; 92(2): 166
[Pubmed] | [DOI]
11 First Synthesis of Betulin 20-Acylhydrazones
Yu. V. Myasoedova, E. R. Belyaeva, L. R. Garifullina, D. A. Prosvirnina, G. Yu. Ishmuratov
Russian Journal of Organic Chemistry. 2022; 58(1): 76
[Pubmed] | [DOI]
12 Synthesis, Molecular Docking and Biological Evaluation of Napthyl N-Acyl Hydrazone Derivatives
J. Sambrajyam, M. Vidya Rani, G. Rajitha
Asian Journal of Chemistry. 2022; 34(7): 1675
[Pubmed] | [DOI]
13 Mini-Review of the Importance of Hydrazides and Their Derivatives—Synthesis and Biological Activity
Suraj N. Mali, Bapu R. Thorat, Deepa Rani Gupta, Anima Pandey
Engineering Proceedings. 2021; 11(1): 21
[Pubmed] | [DOI]
14 [6]-Gingerol-Derived Semi-Synthetic Compound SSi6 Inhibits Tumor Growth and Metastatic Dissemination in Triple-Negative Breast Cancer Xenograft Models
Liany Luna-Dulcey, James Almada da Silva, Veronica Jimenez-Renard, Eduardo Caleiras, Silvana Mouron, Miguel Quintela-Fandino, Marcia R. Cominetti
Cancers. 2021; 13(12): 2855
[Pubmed] | [DOI]
15 Synthesis, Spectroscopic Characterization, and Biological Activities of New Binuclear Co(II), Ni(II), Cu(II), and Zn(II) Diimine Complexes
Ahmed Gaber, Arafa A. M. Belal, Ibrahim M. El-Deen, Nader Hassan, Rozan Zakaria, Walaa F. Alsanie, Ahmed M. Naglah, Moamen S. Refat
Crystals. 2021; 11(3): 300
[Pubmed] | [DOI]
16 Hydrazones of 4-(Trifluoromethyl)benzohydrazide as New Inhibitors of Acetyl- and Butyrylcholinesterase
Martin Krátký, Katarína Svrcková, Quynh Anh Vu, Šárka Štepánková, Jarmila Vinšová
Molecules. 2021; 26(4): 989
[Pubmed] | [DOI]
17 Photocytotoxic Activity of Ruthenium(II) Complexes with Phenanthroline-Hydrazone Ligands
Priscila Pereira Silva-Caldeira, Antônio Carlos Almendagna de Oliveira Junior, Elene Cristina Pereira-Maia
Molecules. 2021; 26(7): 2084
[Pubmed] | [DOI]
18 Hydrazides in the reaction with hydroxypyrrolines: less nucleophilicity – more diversity
Dmitrii A Shabalin, Evgeniya E Ivanova, Igor A Ushakov, Elena Yu Schmidt, Boris A Trofimov
Beilstein Journal of Organic Chemistry. 2021; 17: 319
[Pubmed] | [DOI]
19 Antiplasmodial activity of sulfonylhydrazones: in vitro and in silico approaches
Fernando de Moura Gatti, Renan Augusto Gomes, Amanda Luisa da Fonseca, Elys Juliane Cardoso Lima, Drielli Gomes Vital-Fujii, Alex Guterres Taranto, Fernando de Pilla Varotti, Gustavo Henrique Goulart Trossini
Future Medicinal Chemistry. 2021; 13(3): 233
[Pubmed] | [DOI]
20 Novel pyrazoles as potent growth inhibitors of staphylococci, enterococci and Acinetobacter baumannii bacteria
Ibrahim Alkhaibari, Hansa Raj KC, Duminduni H Angappulige, David Gilmore, Mohammad A Alam
Future Medicinal Chemistry. 2021;
[Pubmed] | [DOI]
21 Antinociceptive and anti-inflammatory effects of hydrazone derivatives and their possible mechanism of action in mice
Maria Alice Miranda Bezerra Medeiros, Mariana Gama e Silva, Jackson de Menezes Barbosa, Érica Martins de Lavor, Tiago Feitosa Ribeiro, Cícero André Ferreira Macedo, Luiz Antonio Miranda de Souza Duarte-Filho, Thiala Alves Feitosa, Jussara de Jesus Silva, Harold Hilarion Fokoue, Cleônia Roberta Melo Araújo, Arlan de Assis Gonsalves, Luciano Augusto de Araújo Ribeiro, Jackson Roberto Guedes da Silva Almeida, John M. Streicher
PLOS ONE. 2021; 16(11): e0258094
[Pubmed] | [DOI]
22 Spectroscopic Determination of Dissociation Constants of Some 4- nitrobenzaldehyde-4-substituted phenyl-1-carbonylhydrazones in Sodium Hydroxide Media
Mirjana S. Jankulovska, Ilinka Spirevska, Vesna Dimova, Milena Jankulovska
Current Pharmaceutical Analysis. 2021; 17(6): 812
[Pubmed] | [DOI]
23 Single-Pot Ozonolytic Synthesis of Acylhydrazones from 1,1-Dichloro-2-ethenyl-2-methylcyclopropane
Yu. V. Myasoedova, L. R. Garifullina, G. Z. Raskil’dina, S. S. Zlotskii, G. Yu. Ishmuratov
Russian Journal of General Chemistry. 2021; 91(4): 743
[Pubmed] | [DOI]
24 Synthesis and Anticancer Activity Evaluation of Some Thienopyrimidine Derivatives
M. A. Mohamed, R. R. Khattab, A. A. F. Wasfy, M. A. Abo-Riya, S. El-Kalyoubi, N. A. Hassan
Russian Journal of Bioorganic Chemistry. 2021; 47(6): 1312
[Pubmed] | [DOI]
25 Synthesis and Structural Characterization of Bioactive Ferrocenyl Substituted Hydrazones
S. Abbas, Imtiaz-ud-Din, M. Mehmood, A. Raheel, R. Ayub, M. Zahid, M. N. Tahir
Russian Journal of Coordination Chemistry. 2021; 47(12): 891
[Pubmed] | [DOI]
26 Synthesis, characterization, and antimicrobial activity of novel N-acetyl,N’-chitosanacetohydrazide and its metal complexes
Noura Y. Elmehbad, Nadia A. Mohamed
International Journal of Polymeric Materials and Polymeric Biomaterials. 2021; : 1
[Pubmed] | [DOI]
27 Facile preparation of new hydrazone compounds and their application for long-term corrosion inhibition of N80 steel in 15% HCl: An experimental study combined with DFTB calculations
Hassane Lgaz, Han-seung Lee
Journal of Molecular Liquids. 2021; : 117952
[Pubmed] | [DOI]
28 Interaction of manganese(II) with the hybrid molecule (E)-4-(2-(pyridin-2-ylmethylene)hydrazinyl)quinazoline: Structure and biological profile
Chrisoula Kakoulidou, Antonios G. Hatzidimitriou, Konstantina C. Fylaktakidou, George Psomas
Polyhedron. 2021; 195: 114986
[Pubmed] | [DOI]
29 Neuroprotective evaluation of novel substituted 1,3,4-oxadiazole and aroylhydrazone derivatives
Valentin R. Karabelyov, Magdalena S. Kondeva-Burdina, Nikolay G. Vassilev, Elena K.-Yovkova, Violina T. Angelova
Bioorganic & Medicinal Chemistry Letters. 2021; : 128516
[Pubmed] | [DOI]
30 Persistent prevalence of supramolecular architectures of novel ultrasonically synthesized hydrazones due to hydrogen bonding [X–H?O; X=N]: Experimental and density functional theory analyses
Muhammad Khalid, Akbar Ali, Sumreen Asim, Muhammad Nawaz Tahir, Muhammad Usman Khan, Lucas Campos Curcino Vieira, Alexander F. de la Torre, Muhammad Usman
Journal of Physics and Chemistry of Solids. 2021; 148: 109679
[Pubmed] | [DOI]
31 Synthesis, spectral characterization, thermo-kinetic and biological studies of some complexes derived from tridentate hydrazone Schiff base
Gajanan Dongare, Anand Aswar
Journal of Saudi Chemical Society. 2021; 25(10): 101325
[Pubmed] | [DOI]
32 Synthesis, characterization, PASS analysis and ADMET properties of oxazolone ring containing hydrazone derivatives
P. Vijaya, G. Sundaraselvan
Materials Today: Proceedings. 2021;
[Pubmed] | [DOI]
33 Gallium(III) complexes of aroylhydrazones derived from nicotinic acid hydrazide in solid state and in solution
Marijana Pocrnic, Darko Kontrec, Snežana Miljanic, Željka Soldin, Ana Budimir, Nives Galic
Journal of Molecular Structure. 2021; 1227: 129564
[Pubmed] | [DOI]
34 Non-covalent interactions abetted supramolecular arrangements of N-Substituted benzylidene acetohydrazide to direct its solid-state network
Muhammad Khalid, Akbar Ali, Muhammad Usman Khan, Muhammad Nawaz Tahir, Anees Ahmad, Muhammad Ashfaq, Riaz Hussain, Sara Figueirêdo de Alcântara Morais, Ataualpa Albert Carmo Braga
Journal of Molecular Structure. 2021; 1230: 129827
[Pubmed] | [DOI]
35 Titanium(IV) complex containing ONO-tridentate Schiff base ligand: Synthesis, crystal structure determination, Hirshfeld surface analysis, spectral characterization, theoretical and computational studies
H. Kargar, M. Fallah-Mehrjardi, R. Behjatmanesh-Ardakani, K.S. Munawar, M. Ashfaq, M.N. Tahir
Journal of Molecular Structure. 2021; 1241: 130653
[Pubmed] | [DOI]
36 Quantum chemical modeling, synthesis, spectroscopic (FT-IR, excited States, UV–Vis) studies, FMO, QTAIM, NBO and NLO analyses of two new azo derivatives
Erfu Huo, Siyamak Shahab, Sultan Al Saud, Weiqin Cheng, Peng Lu, Masoome Sheikhi, Radwan Alnajjar, Sadegh Kaviani
Journal of Molecular Structure. 2021; 1243: 130810
[Pubmed] | [DOI]
37 In vitro and in silico studies of radical scavenging activity of salicylaldehyde benzoylhydrazones
Nadya G. Hristova-Avakumova, Evgenia P. Valcheva, Neda O. Anastassova, Boryana I. Nikolova-Mladenova, Liliya A. Atanasova, Silvia E. Angelova, Denitsa Y. Yancheva
Journal of Molecular Structure. 2021; 1245: 131021
[Pubmed] | [DOI]
38 Ru3+, Mn2+, Co2+, Ni2+, Cu2+, and Zn2+ uni-metallic complexes of 3-(-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl) methylene) hydrazono)indolin-2-one, preparation, structure elucidation and antibacterial activity
Mohamad M.E. Shakdofa, Quad M. Selim, Adel M.E. Shakdofa
Journal of Molecular Structure. 2021; 1246: 131194
[Pubmed] | [DOI]
39 Flavone-based hydrazones as new tyrosinase inhibitors: Synthetic imines with emerging biological potential, SAR, molecular docking and drug-likeness studies
Reem?I. Alsantali, Ehsan?Ullah Mughal, Nafeesa Naeem, Meshari?A. Alsharif, Amina Sadiq, Anser Ali, Rabab.?S. Jassas, Qamar Javed, Asif Javid, Sajjad Hussain Sumrra, Abdulrahman?A. Alsimaree, Muhammad?Naveed Zafar, Basim?H. Asghar, Hatem?M. Altass, Ziad Moussa, Saleh?A. Ahmed
Journal of Molecular Structure. 2021; : 131933
[Pubmed] | [DOI]
40 Structural, spectroscopic, quantum chemical, and molecular docking investigation of (E)-N'-(2,5-dimethoxybenzylidene)picolinohydrazide
Eswaran Kavitha, Devarajan Ramarajan, Aleksandra Rakic, Dušan Dimic, Shanmugam Sudha, Putta Narasimhan Nirmala
Journal of Molecular Structure. 2021; : 132259
[Pubmed] | [DOI]
41 Synthesis and Cytotoxic Activity of 5a-Pregnanolone Hydrazones
N. Sh. Nadaraia, M. L. Kakhabrishvili, N. N. Barbakadze, V. D. Mshvildadze, K. G. Mulkidzhanyan, A. Pichette
Chemistry of Natural Compounds. 2021; 57(2): 395
[Pubmed] | [DOI]
42 Formation of a new CuII–triazole ester complex from 1,2-cyclohexanedione-bis(p-bromobenzohydrazone) compound as a consequence of copper(II)-catalyzed click reaction
Ahmed Jasim M. Al-Karawi, Al-Ameen Bariz OmarAli, Necmi Dege, Sevgi Kansiz
Chemical Papers. 2021; 75(8): 3901
[Pubmed] | [DOI]
43 Biologically Active Quinoline-Hydrazone Conjugates as Potential Trypanosoma cruzi DHFR-TS Inhibitors: Docking, Molecular Dynamics, MM/PBSA and Drug-Likeness Studies
Andrés F. Yepes, Jorge Quintero-Saumeth, Wilson Cardona-Galeano
ChemistrySelect. 2021; 6(12): 2928
[Pubmed] | [DOI]
44 Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard’s T and P reagents
Nevena Stevanovic, Paolo Pio Mazzeo, Alessia Bacchi, Ivana Z. Matic, Marija Ðordic Crnogorac, Tatjana Stanojkovic, Miroslava Vujcic, Irena Novakovic, Dušanka Radanovic, Maja Šumar-Ristovic, Dušan Sladic, Bofžidar Cobeljic, Katarina Andelkovic
JBIC Journal of Biological Inorganic Chemistry. 2021; 26(8): 863
[Pubmed] | [DOI]
45 N , N -Dialkylhydrazones as Versatile Umpolung Reagents in Enantioselective Anion-Binding Catalysis
Melania Gómez-Martínez, María Carmen Pérez-Aguilar, Dariusz G. Piekarski, Constantin G. Daniliuc, Olga García Mancheño
Angewandte Chemie International Edition. 2021; 60(10): 5102
[Pubmed] | [DOI]
46 Iron(III), copper(II), cadmium(II), and mercury(II) complexes of isatin carbohydrazone Schiff base ligand (H 3 L): Synthesis, characterization, X-ray diffraction, cyclic voltammetry, fluorescence, density functional th
Adel M. Younis, Mohammed M. El-Gamil, Tawfik H. Rakha, Gaber M. Abu El-Reash
Applied Organometallic Chemistry. 2021; 35(7)
[Pubmed] | [DOI]
47 N , N -Dialkylhydrazones as Versatile Umpolung Reagents in Enantioselective Anion-Binding Catalysis
Melania Gómez-Martínez, María Carmen Pérez-Aguilar, Dariusz G. Piekarski, Constantin G. Daniliuc, Olga García Mancheño
Angewandte Chemie. 2021; 133(10): 5162
[Pubmed] | [DOI]
48 Synthesis and characterization of novel tricyanofuran hydrazone probe: solvatochromism, density-functional theory calculation and selective fluorescence, and colorimetric determination of iron (III)
Amal Al-Azmi, Elizabeth John
Luminescence. 2021; 36(5): 1220
[Pubmed] | [DOI]
49 Ammonium-Charged Sterically Hindered Phenols with Antioxidant and Selective Anti-Gram-Positive Bacterial Activity
Andrei V. Bogdanov, Kamilla R. Iskhakova, Alexandra D. Voloshina, Anastasia S. Sapunova, Natalia V. Kulik, Natalia V. Terekhova, Maxim V. Arsenyev, Guzel K. Ziyatdinova, Sergey V. Bukharov
Chemistry & Biodiversity. 2020; 17(5)
[Pubmed] | [DOI]
50 1,3-Oxazole-isoniazid hybrids: Synthesis, antitubercular activity, and their docking studies
Shailesh R. Shah, Kanubhai D. Katariya
Journal of Heterocyclic Chemistry. 2020; 57(4): 1682
[Pubmed] | [DOI]
51 N -Trifluoromethyl Hydrazines, Indoles and Their Derivatives
Samir Bouayad-Gervais, Thomas Scattolin, Franziska Schoenebeck
Angewandte Chemie. 2020; 132(29): 12006
[Pubmed] | [DOI]
52 Facile Ultrasound-Based Synthesis, SC-XRD, DFT Exploration of the Substituted Acyl-Hydrazones: An Experimental and Theoretical Slant towards Supramolecular Chemistry
Muhammad Khalid, Akbar Ali, Saba Abid, Muhammad Nawaz Tahir, Muhammad Usman Khan, Muhammad Ashfaq, Muhammad Imran, Anees Ahmad
ChemistrySelect. 2020; 5(47): 14844
[Pubmed] | [DOI]
53 N -Trifluoromethyl Hydrazines, Indoles and Their Derivatives
Samir Bouayad-Gervais, Thomas Scattolin, Franziska Schoenebeck
Angewandte Chemie International Edition. 2020; 59(29): 11908
[Pubmed] | [DOI]
54 Synthesis and antimycobacterial evaluation of pyridinyl- and pyrazinylhydrazone derivatives
Alessandra C. Pinheiro, Thaís C. M. Nogueira, Gabriela E. Pereira, Cristina Lourenço, Marcus V. N. de Souza
Medicinal Chemistry Research. 2020; 29(9): 1662
[Pubmed] | [DOI]
55 Synthesis and characterization of (E)-2-(1-hydrazonoethyl)-4,5-dimethylphenol from 2-hydroxy-4,5-dimethylacetophenone
Dinkar Gagare, Raju Patil, Rama Lokhande, Poonam Dwivedi, Ajay Deshmukh
Journal of Chemical Sciences. 2020; 132(1)
[Pubmed] | [DOI]
56 Synthesis and antiproliferative activity of salicylidenehydrazones based on indole-2(3)-carboxylic acids
Andrey G. Vasin, Lyubov G. Dezhenkova, Ivan V. Ivanov, Alexander M. Scherbakov, Andrey E. Shchekotikhin
Chemistry of Heterocyclic Compounds. 2020; 56(6): 734
[Pubmed] | [DOI]
57 Hydrazone comprising compounds as promising anti-infective agents: chemistry and structure-property relationship
P.C. Sharma, D. Sharma, A. Sharma, N. Saini, R. Goyal, M. Ola, R. Chawla, V.K. Thakur
Materials Today Chemistry. 2020; 18: 100349
[Pubmed] | [DOI]
58 Synthesis, molecular structure, spectroscopic and theoretical investigation of 5-chlorosalicylaldehyde-2,4-dinitrophenylhydrazone
Diego M. Gil
Journal of Molecular Structure. 2020; 1205: 127589
[Pubmed] | [DOI]
59 Microwave and conventional synthesis of ester based dicationic pyridinium ionic liquids carrying hydrazone linkage: DNA binding, anticancer and docking studies
Salsabeel A. Al-Sodies, Mohamed Reda Aouad, Saleh Ihmaid, Ateyatallah Aljuhani, Mouslim Messali, Imran Ali, Nadjet Rezki
Journal of Molecular Structure. 2020; 1207: 127756
[Pubmed] | [DOI]
60 Copper(II) complexes of aroylhydrazones: Preparation and structural characterization
Adriana Kendel, Snežana Miljanic, Darko Kontrec, Željka Soldin, Nives Galic
Journal of Molecular Structure. 2020; 1207: 127783
[Pubmed] | [DOI]
61 Spectroscopic, crystal structural, theoretical and biological studies of phenylacetohydrazide Schiff base derivatives and their copper complexes
Samir M. El-Medani, Abdelmoneim A. Makhlouf, Hussein Moustafa, Manal A. Afifi, Matti Haukka, Ramadan M. Ramadan
Journal of Molecular Structure. 2020; 1208: 127860
[Pubmed] | [DOI]
62 Synthesis and X-ray crystal structures of two different zinc (II) complexes of N,N'-cyclohexane-1,2-diylidene-bis(4-fluorobenzoylhydrazide) based on zinc salt effect
Al-Ameen Bariz OmarAli, Ahmed Jasim M. Al-Karawi, Necmi Dege, Sevgi Kansiz, Hiba Abdulkareem D. Ithawi
Journal of Molecular Structure. 2020; 1217: 128387
[Pubmed] | [DOI]
63 Synthesis, experimental and theoretical characterization of (E)-2-((2,3-dimethylphenyl)amino)-N’-(furan-2-ylmethylene)benzohydrazide
Mustafa R. Albayati, Sevgi Kansiz, Hassane Lgaz, Savas Kaya, Necmi Dege, Ismat H. Ali, Rachid Salghi, Ill-Min Chung
Journal of Molecular Structure. 2020; 1219: 128518
[Pubmed] | [DOI]
64 Physicochemical characterization of antimony(III), copper(II) and silver(I) complexes with 4-nitroimidazole-derived hydrazones
Ana P.A. Oliveira, Micael Ferencs, Vivianne O. Azevedo, Renata Diniz, Sonia R.W. Louro, Odivaldo C. Alves, Heloisa Beraldo
Journal of Molecular Structure. 2020; 1222: 128874
[Pubmed] | [DOI]
65 Synthesis of Ag-AgCl nanoparticles capped by calix[4]resorcinarene-mPEG conjugate and their antimicrobial activity
Alina M. Shumatbaeva, Julia E. Morozova, Yana V. Shalaeva, Alina F. Saifina, Aidar T. Gubaidullin, Victor V. Syakaev, Anastasia S. Sapunova, Alexandra D. Voloshina, Irek R. Nizameev, Marsil K. Kadirov, Kseniya S. Bulygina, Vasily M. Babaev, Igor S. Antipin
Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2020; 602: 125124
[Pubmed] | [DOI]
66 Zn(II) complexes of (E)-4-(2-(pyridin-2-ylmethylene)hydrazinyl)quinazoline in combination with non-steroidal anti-inflammatory drug sodium diclofenac: Structure, DNA binding and photo-cleavage studies, antioxidant activity and interaction with albumin
Chrisoula Kakoulidou, Panagiotis S. Gritzapis, Antonios G. Hatzidimitriou, Konstantina C. Fylaktakidou, George Psomas
Journal of Inorganic Biochemistry. 2020; 211: 111194
[Pubmed] | [DOI]
67 Novel hydrazono-hydrazonoyl chlorides containing pyrazole moiety for concurrent dyeing and practical finishing of cotton fabrics
Bakr F. Abdel-Wahab, Hanan A. Mohamed, Hesham M. Fahmy
Journal of Materials Research and Technology. 2020; 9(4): 7380
[Pubmed] | [DOI]
68 Synthesis of half sandwich platinum group metal complexes containing pyridyl benzothiazole hydrazones: Study of bonding modes and antimicrobial activity
Lincoln Dkhar, Venkanna Banothu, Werner Kaminsky, Mohan Rao Kollipara
Journal of Organometallic Chemistry. 2020; 914: 121225
[Pubmed] | [DOI]
69 Protonation of hydrazones derived from pyridoxal 5'-phosphate: Thermodynamic and structural elucidation
G.A. Gamov, A.N. Meshkov, M.N. Zavalishin, A. Yu. Khokhlova, A.V. Gashnikova, V.V. Aleksandriiskii, V.A. Sharnin
Journal of Molecular Liquids. 2020; 305: 112822
[Pubmed] | [DOI]
70 Grinding induced catalyst free, multicomponent synthesis of Indoloindole pyrimidine
Suresh Kumar Maury, Savita Kumari, Ambuj Kumar Kushwaha, Arsala Kamal, Himanshu Kumar Singh, Dhirendra Kumar, Sundaram Singh
Tetrahedron Letters. 2020; 61(41): 152383
[Pubmed] | [DOI]
71 An Experimental and Computational Exploration on the Electronic, Spectroscopic, and Reactivity Properties of Novel Halo-Functionalized Hydrazones
Akbar Ali, Muhammad Khalid, Muhammad Abdul Rehman, Farooq Anwar, Hafiz Zain-Ul-Aabidin, Muhammad Nadeem Akhtar, Muhammad Usman Khan, Ataualpa Albert Carmo Braga, Mohammed A. Assiri, Muhammad Imran
ACS Omega. 2020; 5(30): 18907
[Pubmed] | [DOI]
72 Novel multifunctional and multitarget homo- (Fe2) and heterobimetallic [(Fe,M) with M = Re or Mn] sulfonyl hydrazones
Yosselin Huentupil, Patricio Chung, Néstor Novoa, Rodrigo Arancibia, Pascal Roussel, Juan Oyarzo, A. Hugo Klahn, Carlos Silva, Carme Calvis, Ramon Messeguer, Ramón Bosque, Concepción López
Dalton Transactions. 2020; 49(35): 12249
[Pubmed] | [DOI]
73 Two new zinc(II) and mercury(II) complexes based on N,N'-(cyclohexane-1,2-diylidene)bis(4-fluorobenzohydrazide): synthesis, crystal structures and antibacterial activities
Al-Ameen Bariz OmarAli, Ahmed Jasim M. Al-Karawi, Adil A. Awad, Necmi Dege, Sevgi Kansiz, Erbil Agar, Zaman Ahmed Hussein, Iman Rajab Mohammed
Acta Crystallographica Section C Structural Chemistry. 2020; 76(5): 476
[Pubmed] | [DOI]
74 Catalyst-Free One-Pot Three-Component Synthesis of 4-Hydroxy-3-pyrazolylcoumarins in Ethanol at Room Temperature: Enolisable Aroylhydrazones as Efficient Ambident Nucleophile
Sayan Mukherjee, Animesh Pramanik
ACS Sustainable Chemistry & Engineering. 2020; 8(1): 403
[Pubmed] | [DOI]
75 Microwave-Assisted Synthesis, Antioxidant and Toxicological Evaluation of a Hydrazone, 1-(4-chlorobenzylidene)-2-phenylhydrazine
N Afriana, N Frimayanti, A Zamri, J Jasril
Journal of Physics: Conference Series. 2020; 1655(1): 012036
[Pubmed] | [DOI]
76 Enantiotropic Transformation of Carbethoxyhydrazones of Acetophenones
E. A. Popova, O. V. Stepanova, V. V. Bessonov, G. D. Nepochatyi, L. M. Pevzner, M. L. Petrov
Russian Journal of General Chemistry. 2020; 90(2): 311
[Pubmed] | [DOI]
77 1,2,4-Triazole-Based Hybrid Heterocyclic Carbaldehyde Hydrazones and Their Effect on DNA Methylation Level
T. R. Hovsepyan, M. R. Hakobyan, R. E. Muradyan, L. E. Nersesyan, A. S. Aharonyan, I. S. Danielyan, N. S. Minasyan, A. A. Harutyunyan
Russian Journal of Organic Chemistry. 2020; 56(12): 2137
[Pubmed] | [DOI]
78 Heterocyclization of 2-(2-phenylhydrazono)cyclohexane-1,3-dione to Synthesis Thiophene, Pyrazole and 1,2,4-triazine Derivatives with Anti-Tumor and Tyrosine Kinase Inhibitions
Rafat M. Mohareb, Ensaf S. Alwan
Anti-Cancer Agents in Medicinal Chemistry. 2020; 20(10): 1209
[Pubmed] | [DOI]
79 Synthesis and biological evaluation of 2-(4-methylsulfonyl phenyl) indole derivatives: multi-target compounds with dual antimicrobial and anti-inflammatory activities
Ahmed M. M. Shaker, Eman K. A. Abdelall, Khaled R. A. Abdellatif, Hamdy M. Abdel-Rahman
BMC Chemistry. 2020; 14(1)
[Pubmed] | [DOI]
80 A study of antituberculosis activities and crystal structures of (E)-2-[2-(arylidene)hydrazinyl]pyrimidine and (E)-N 1-(arylidene)pyrimidine-2-carbohydrazide derivatives
Alessandra C. Pinheiro, Thaís C. M. Nogueira, Cristiane França da Costa, Cristina Lourenço, John N. Low, James L. Wardell, Solange M. S. V. Wardell, Marcus V. N. de Souza
Zeitschrift für Naturforschung B. 2020; 75(12): 1011
[Pubmed] | [DOI]
81 Computer-Aided Design, Synthesis, and Antiviral Evaluation of Novel Acrylamides as Potential Inhibitors of E3-E2-E1 Glycoproteins Complex from Chikungunya Virus
Gabriel Felipe Silva Passos, Matheus Gabriel Moura Gomes, Thiago Mendonça de Aquino, João Xavier de Araújo-Júnior, Stephannie Janaina Maia de Souza, João Pedro Monteiro Cavalcante, Elane Conceição dos Santos, Ênio José Bassi, Edeildo Ferreira da Silva-Júnior
Pharmaceuticals. 2020; 13(7): 141
[Pubmed] | [DOI]
82 Green Synthesis, SC-XRD, Non-Covalent Interactive Potential and Electronic Communication via DFT Exploration of Pyridine-Based Hydrazone
Akbar Ali, Muhammad Khalid, Saba Abid, Muhammad Tahir, Javed Iqbal, Muhammad Ashfaq, Fariha Kanwal, Changrui Lu, Muhammad Rehman
Crystals. 2020; 10(9): 778
[Pubmed] | [DOI]
83 Green Synthesis of new heterocyclic hydrazones, spectroscopic characterization
Blanca Martha Cabrera-Vivas, Angel Palillero-Cisneros, Lidia Meléndez-Balbuena, Laura Morales-Lara
ECORFAN Journal-Ecuador. 2019; : 1
[Pubmed] | [DOI]
84 The Use of Hydrazones for Biomedical Applications
Jenna Wahbeh, Sarah Milkowski
SLAS Technology. 2019; 24(2): 161
[Pubmed] | [DOI]
85 Novel 4-methoxynaphthalene-N-acylhydrazones as potential for paracoccidioidomycosis and tuberculosis co-infection
Andrew MF Rozada, Franciele AV Rodrigues, Eloísa G Sampiron, Flavio AV Seixas, Ernani A Basso, Regiane BL Scodro, Érika S Kioshima, Gisele F Gauze
Future Microbiology. 2019; 14(7): 587
[Pubmed] | [DOI]
86 Photoredox Decarboxylative C(sp3)–N Coupling of a-Diazoacetates with Alkyl N-Hydroxyphthalimide Esters for Diversified Synthesis of Functionalized N-Alkyl Hydrazones
Chun-Ming Chan, Qi Xing, Yip-Chi Chow, Sing-Fung Hung, Wing-Yiu Yu
Organic Letters. 2019; 21(19): 8037
[Pubmed] | [DOI]
87 Exploration of C–H Transformations of Aldehyde Hydrazones: Radical Strategies and Beyond
Pan Xu, Weipeng Li, Jin Xie, Chengjian Zhu
Accounts of Chemical Research. 2018; 51(2): 484
[Pubmed] | [DOI]
88 Chiral lactic hydrazone derivatives as potential bioactive antibacterial agents: Synthesis, spectroscopic, structural and molecular docking studies
Nader Noshiranzadeh,Azam Heidari,Fakhri Haghi,Rahman Bikas,Tadeusz Lis
Journal of Molecular Structure. 2017; 1128: 391
[Pubmed] | [DOI]
89 Copper-Catalyzed Transformation of Hydrazones into Halogenated Azabutadienes, Versatile Building Blocks for Organic Synthesis
Valentine G. Nenajdenko,Alexey V. Shastin,Vladimir M. Gorbachev,Sergey V. Shorunov,Vasiliy M. Muzalevskiy,Anna I. Lukianova,Pavel V. Dorovatovskii,Victor N. Khrustalev
ACS Catalysis. 2017; 7(1): 205
[Pubmed] | [DOI]
90 Continuous Flow a-Arylation of N,N-Dialkylhydrazones under Visible-Light Photoredox Catalysis
Juan A. Vega,José Manuel Alonso,Gabriela Méndez,Myriam Ciordia,Francisca Delgado,Andrés A. Trabanco
Organic Letters. 2017; 19(4): 938
[Pubmed] | [DOI]
91 Perfluoroalkylation of Aryl-N,N-dimethyl Hydrazones Using Hypervalent Iodine(III) Reagents or Perfluoroalkyl Iodides
Benjamin Janhsen,Armido Studer
The Journal of Organic Chemistry. 2017;
[Pubmed] | [DOI]
92 The mutagenic mechanism of oxygenated alkylhydrazones occurs through alkyl radicals and alkyldiazonium ions
Keiko Inami,Miki Takada,Miho Nagata,Toshinori Higashi,Masataka Mochizuki
Toxicol. Res.. 2017;
[Pubmed] | [DOI]
93 Stereoselective, solvent free, highly efficient synthesis of aldo- and keto-N-acylhydrazones applying grindstone chemistry
José Maurício dos Santos Filho,Savio Moita Pinheiro
Green Chem.. 2017;
[Pubmed] | [DOI]
94 Schiff bases in medicinal chemistry: a patent review (2010-2015)
Abdul Hameed,Mariya al-Rashida,Maliha Uroos,Syed Abid Ali,Khalid Mohammed Khan
Expert Opinion on Therapeutic Patents. 2017; 27(1): 63
[Pubmed] | [DOI]
95 Synthesis of bis[9-hydroxy-1-{N-hydroxy-2-[(2,4-dinitrophenyl)hydrazinylidene]alkanimidoyl}]-1,9-dihydro[C60-I h][5,6]fullerenes
Z. S. Kinzyabaeva,R. G. Bulgakov
Russian Journal of Organic Chemistry. 2017; 53(1): 118
[Pubmed] | [DOI]
96 Rhenium(I) complexes with bidentate carbohydrazide Schiff bases: Synthesis, characterization, computational and DNA interaction studies
Muhammed Bilaal Ismail,Irvin Noel Booysen,Matthew Piers Akerman,Craig Grimmer
Journal of Organometallic Chemistry. 2017;
[Pubmed] | [DOI]
97 Oxorhenium(V) complexes with bidentate carbohydrazide Schiff bases: synthesis, characterization and DNA interaction studies
Muhammed Bilaal Ismail,Irvin Noel Booysen,Matthew Piers Akerman
Transition Metal Chemistry. 2017;
[Pubmed] | [DOI]
98 New hydrazine and hydrazide quinoxaline 1,4-di-N-oxide derivatives: In silico ADMET, antiplasmodial and antileishmanial activity
Miguel Quiliano,Adriana Pabón,Gustavo Ramirez-Calderon,Carlos Barea,Eric Deharo,Silvia Galiano,Ignacio Aldana
Bioorganic & Medicinal Chemistry Letters. 2017;
[Pubmed] | [DOI]
99 Synthesis and biological evolution of hydrazones derived from 4-(trifluoromethyl)benzohydrazide
Martin Krátký,Szilvia Bosze,Zsuzsa Baranyai,Jirina Stolaríková,Jarmila Vinšová
Bioorganic & Medicinal Chemistry Letters. 2017;
[Pubmed] | [DOI]
100 A detailed experimental and computational study of monocarbohydrazones
Aleksandra R. Božic,Nenad R. Filipovic,Tatjana Ž. Verbic,Miloš K. Milcic,Tamara R. Todorovic,Ilija N. Cvijetic,Olivera R. Klisuric,Marina M. Radišic,Aleksandar D. Marinkovic
Arabian Journal of Chemistry. 2017;
[Pubmed] | [DOI]
101 In vitro and in silico evaluation of chromene based aroyl hydrazones as anticonvulsant agents
Violina T. Angelova,Yulian Voynikov,Pavlina Andreeva-Gateva,Slavina Surcheva,Nikolay Vassilev,Tania Pencheva,Jana Tchekalarova
Medicinal Chemistry Research. 2017;
[Pubmed] | [DOI]
102 Synthesis, antiprotozoal activity and cytotoxicity in U-937 macrophages of triclosan–hydrazone hybrids
Sebastian Vergara,Miguel Carda,Raül Agut,Lina M. Yepes,Iván D. Vélez,Sara M. Robledo,Wilson Cardona Galeano
Medicinal Chemistry Research. 2017;
[Pubmed] | [DOI]
103 Synthesis, Molecular Modeling, and Evaluation of Novel Sulfonylhydrazones as Acetylcholinesterase Inhibitors for Alzheimeræs Disease
Thais B. Fernandes,Micael R. Cunha,Renata P. Sakata,Thalita M. Candido,André R. Baby,Maurício T. Tavares,Euzébio G. Barbosa,Wanda P. Almeida,Roberto Parise-Filho
Archiv der Pharmazie. 2017; : 1700163
[Pubmed] | [DOI]
104 A Copper-Benzotriazole-Based Coordination Polymer Catalyzes the Efficient One-Pot Synthesis of (N' -Substituted)-hydrazo-4-aryl-1,4-dihydropyridines from Azines
Michael Kallitsakis,Edward Loukopoulos,Alaa Abdul-Sada,Graham J. Tizzard,Simon J. Coles,George E. Kostakis,Ioannis N. Lykakis
Advanced Synthesis & Catalysis. 2016;
[Pubmed] | [DOI]
105 2, 2'-Dihydroxybenzophenones and Derivatives. Efficient Synthesis and Structure Endoscopy by DFT and NMR. Credentials as Potent Antiinflammatory Agents.
Demeter Tzeli,Pawel Kozielewicz,Maria Zervou,Constantinos Potamitis,Katerina Kokkotou,Benedikt Rak,Anthi Petrou,Evaggelia Tsolaki,Antonios Gavalas,Athina Geronikaki,Ioannis D. Petsalakis,Petros G. Tsoungas
ChemistrySelect. 2016; 1(10): 2426
[Pubmed] | [DOI]
106 Design, Synthesis, and Evaluation of 2-Amino-6-nitrobenzothiazole-Derived Hydrazones as MAO Inhibitors: Role of the Methylene Spacer Group
Rati K. P. Tripathi,Senthil R. Ayyannan
ChemMedChem. 2016;
[Pubmed] | [DOI]
107 Phloretin-induced cytoprotective effects on mammalian cells: A mechanistic view and future directions
Marcos Roberto de Oliveira
BioFactors. 2016; 42(1): 13
[Pubmed] | [DOI]
108 Intramolecular single H bonding vs bifurcation in tuning the conformation of 2,2'-dihydroxybenzophenone and its derivatives: a DFT insight
Demeter Tzeli,Petros G. Tsoungas,Ioannis D. Petsalakis,Pawel Kozielewicz
Structural Chemistry. 2016;
[Pubmed] | [DOI]
109 Synthesis and evaluation of antioxidant phenolic diaryl hydrazones as potent antiangiogenic agents in atherosclerosis
Corinne Vanucci-Bacqué,Caroline Camare,Chantal Carayon,Corinne Bernis,Michel Baltas,Anne Nègre-Salvayre,Florence Bedos-Belval
Bioorganic & Medicinal Chemistry. 2016;
[Pubmed] | [DOI]
110 Protective effect of Novel Substituted Nicotine Hydrazide analogues against Hypoxic Brain Injury in Neonatal Rats via inhibition of Caspase
Chang-bo Deng,Juan Li,Lu-yi Li,Feng-jie Sun
Bioorganic & Medicinal Chemistry Letters. 2016;
[Pubmed] | [DOI]
111 Synthesis and in vitro antifungal activity of isoniazid-derived hydrazones against Coccidioides posadasii
Rossana de Aguiar Cordeiro,Charlline Vládia Silva de Melo,Francisca Jakelyne de Farias Marques,Rosana Serpa,Antônio José de Jesus Evangelista,Erica Pacheco Caetano,Jair Mafezoli,Maria da Conceição Ferreira de Oliveira,Marcos Reinaldo da Silva,Tereza de Jesus Pinheiro Gomes Bandeira,José Luciano Bezerra Moreira,Raimunda Sâmia Nogueira Brilhante,Marcos Fábio Gadelha Rocha,José Júlio Costa Sidrim
Microbial Pathogenesis. 2016;
[Pubmed] | [DOI]
112 Lewis acid-promoted direct synthesis of N-unsubstituted hydrazones via the reaction of hydrazine with acetophenone and isatin derivatives
A. S. El-Azab,H. A. Ghabbour,W. M. El-Husseiny,A. R. Maarouf,M. A. Mohamed,A. A.-M. Abdel-Aziz
Russian Journal of General Chemistry. 2016; 86(12): 2837
[Pubmed] | [DOI]
113 (7-Chloroquinolin-4-yl)arylhydrazones: Candida albicansenzymatic repression and cytotoxicity evaluation, Part 2
Pedro Henrique de Azambuja Carvalho,Auri Rocha Duval,Fabio Renato Manzolli Leite,Fernanda Nedel,Wilson Cunico,Rafael Guerra Lund
Journal of Enzyme Inhibition and Medicinal Chemistry. 2016; 31(1): 126
[Pubmed] | [DOI]
114 Crystal structures of (E)-2-((2-((pyridin-2-yl)hydrazonyl)methyl)phenolic compounds: different sets of classical hydrogen bonds, X–H···Y (X, Y = O, N)
Nathasha R. de L. Correira, Thais C.M. Noguiera, Alessandra C. Pinheiro, Marcus V.N. de Souza, James L. Wardell, Solange M.S.V. Wardell
Zeitschrift für Kristallographie - Crystalline Materials. 2016; 231(5): 271
[Pubmed] | [DOI]
115 Synthesis of some new hydrazide-hydrazones related to isatin and its Mannich and Schiff bases
Elsayed M. Afsah, Saad S. Elmorsy, Soha M. Abdelmageed, Zaki E. Zaki
Zeitschrift für Naturforschung B. 2016; 71(11): 1147
[Pubmed] | [DOI]
116 Azole-based compounds as antiamoebic agents: a perspective using theoretical calculations
Md. Mushtaque,Shahzaib Ahamad,Meriyam Jahan,Kakul Hussain,Mohd Shahid Khan
RSC Adv.. 2016; 6(1): 815
[Pubmed] | [DOI]
117 A metal free reduction of aryl-N-nitrosamines to the corresponding hydrazines using a sustainable reductant thiourea dioxide
Priyanka Chaudhary,Surabhi Gupta,Popuri Sureshbabu,Shahulhameed Sabiah,Jeyakumar Kandasamy
Green Chem.. 2016; 18(23): 6215
[Pubmed] | [DOI]
118 Quinoline based mono- and bis-(thio)carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models
Aleksandra Božic,Aleksandar Marinkovic,Snežana Bjelogrlic,Tamara R. Todorovic,Ilija N. Cvijetic,Irena Novakovic,Christian D. Muller,Nenad R. Filipovic
RSC Adv.. 2016; 6(106): 104763
[Pubmed] | [DOI]
119 N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes
Mauro Carcelli,Dominga Rogolino,Anna Gatti,Laura De Luca,Mario Sechi,Gyanendra Kumar,Stephen W. White,Annelies Stevaert,Lieve Naesens
Scientific Reports. 2016; 6: 31500
[Pubmed] | [DOI]
120 Environmentally Safe Condition for the Synthesis of Aryl and Alkyl Sulfonyl Hydrazones via One-Pot Reaction
Micael R. Cunha,Maurício T. Tavares,Camila F. Carvalho,Nuno A. T. Silva,Alfredo D. F. Souza,Gustavo J. V. Pereira,Fábio F. Ferreira,Roberto Parise-Filho
ACS Sustainable Chemistry & Engineering. 2016;
[Pubmed] | [DOI]
121 On the roles of close shell interactions in the structure of acyl-substituted hydrazones: An experimental and theoretical approach
Aamer Saeed,M. Ifzan Arshad,Michael Bolte,Adolfo C. Fantoni,Zuly Y. Delgado Espinoza,Mauricio F. Erben
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2016; 157: 138
[Pubmed] | [DOI]
122 Synthesis, crystal structure, characterization and biological activity of 2,5-hexanedione bis(isonicotinylhydrazone) and N-(2,5-dimethyl-1H-pyrrol-1-yl)isonicotinamide complexes
Bakir Jeragh,Mayada S. Ali,Ahmed A. El-Asmy
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2015; 150: 504
[Pubmed] | [DOI]
123 An enolato-bridged dinuclear Cu(ii) complex with a coumarin-assisted precursor: a spectral, magnetic and biological study
Kuheli Das,Uttam Panda,Amitabha Datta,Suman Roy,Sudipa Mondal,Chiara Massera,Tulin Askun,Pinar Celikboyun,Eugenio Garribba,Chittaranjan Sinha,Kushi Anand,Takashiro Akitsu,Kana Kobayashi
New J. Chem.. 2015; 39(9): 7309
[Pubmed] | [DOI]
124 Azine or hydrazone? The dilemma in amidinohydrazones
Ashok Ramakrishnan,Sumit S. Chourasiya,Prasad V. Bharatam
RSC Adv.. 2015; 5(69): 55938
[Pubmed] | [DOI]
125 Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids
Visesato Mor, Antonella Rella, Amir M. Farnoud, Ashutosh Singh, Mansa Munshi, Arielle Bryan, Shamoon Naseem, James B. Konopka, Iwao Ojima, Erika Bullesbach, Alan Ashbaugh, Michael J. Linke, Melanie Cushion, Margaret Collins, Hari Krishna Ananthula, Larry Sallans, Pankaj B. Desai, Nathan P. Wiederhold, Annette W. Fothergill, William R. Kirkpatrick, Thomas Patterson, Lai Hong Wong, Sunita Sinha, Guri Giaever, Corey Nislow, Patrick Flaherty, Xuewen Pan, Gabriele Vargas Cesar, Patricia de Melo Tavares, Susana Frases, Kildare Miranda, Marcio L. Rodrigues, Chiara Luberto, Leonardo Nimrichter, Maurizio Del Poeta, Julian E. Davies
mBio. 2015; 6(3)
[Pubmed] | [DOI]
126 Synthesis, leishmanicidal, trypanocidal and cytotoxic activity of quinoline-hydrazone hybrids
Juan Carlos Coa,Wilson Castrillón,Wilson Cardona,Miguel Carda,Victoria Ospina,July Andrea Muñoz,Iván D. Vélez,Sara M. Robledo
European Journal of Medicinal Chemistry. 2015; 101: 746
[Pubmed] | [DOI]
127 A versatile salicyl hydrazonic ligand and its metal complexes as antiviral agents
D. Rogolino,M. Carcelli,A. Bacchi,C. Compari,Laura Contardi,E. Fisicaro,A. Gatti,M. Sechi,A. Stevaert,L. Naesens
Journal of Inorganic Biochemistry. 2015; 150: 9
[Pubmed] | [DOI]
128 Potent antimicrobial agents against azole-resistant fungi based on pyridinohydrazide and hydrazomethylpyridine structural motifs
Gregory L. Backes,Branko S. Jursic,Donna M. Neumann
Bioorganic & Medicinal Chemistry. 2015; 23(13): 3397
[Pubmed] | [DOI]
129 Synthesis, characterization, X-ray crystal structure, electrochemical evaluation and anti-cancer studies of a mixed ligand Cu(II) complex of (E)-N'-((2-hydroxynaphthalen-1-yl)methylene)acetohydrazide
IRAN SHEIKHSHOAIE,S YOUSEF EBRAHIMIPOUR,MAHDIEH SHEIKHSHOAIE,MARYAM MOHAMADI,MEHDI ABBASNEJAD,HADI AMIRI RUDBARI,GIUSEPPE BRUNO
Journal of Chemical Sciences. 2015; 127(12): 2193
[Pubmed] | [DOI]
130 Synthesis, characterization and in vitro antimicrobial evaluation of some novel hydrazone derivatives bearing pyrimidinyl and pyrazolyl moieties as a promising heterocycles
Raj Kamal,Vipan Kumar,Vikas Bhardwaj,Vikas Kumar,Kamal Rai Aneja
Medicinal Chemistry Research. 2015; 24(6): 2551
[Pubmed] | [DOI]
131 Application of a Ball Milling Technique for the Condensation of Anthranilic Hydrazides with Aromatic Aldehydes Towards 4-Quinazolinone Derivatives*
T. Magyar,F. Miklós,L. Lázár,F. Fülöp
Chemistry of Heterocyclic Compounds. 2015; 50(10): 1464
[Pubmed] | [DOI]
132 Copper-Catalyzed Trifluoromethylation of AliphaticN-Arylhydrazones: A Concise Synthetic Entry to 2-Trifluoromethylindoles from Simple Aldehydes
Alexis Prieto,Mélissa Landart,Olivier Baudoin,Nuno Monteiro,Didier Bouyssi
Advanced Synthesis & Catalysis. 2015; 357(13): 2939
[Pubmed] | [DOI]
133 Synthesis and biological activity of novel amidrazones incorporating 5-nitroimidazole, ciprofloxacin, and 7-chloro-4-piperazinylquinoline
Haythem A. Saadeh,Khaled M. Al-Qaoud,Luay F. Abu-Qatouseh,Penelope A. Shihab,Hargobinder Kaur,Kapil Goyal,Rakesh Sehgal,Mohammad S. Mubarak
Medicinal Chemistry Research. 2014;
[Pubmed] | [DOI]
134 Synthesis and antifungal activity of substituted salicylaldehyde hydrazones, hydrazides and sulfohydrazides
Gregory L. Backes,Donna M. Neumann,Branko S. Jursic
Bioorganic & Medicinal Chemistry. 2014; 22(17): 4629
[Pubmed] | [DOI]
135 Antibacterial activities of novel nicotinic acid hydrazides and their conversion into N-acetyl-1,3,4-oxadiazoles
Rami Y. Morjan,Ahmed M. Mkadmh,Ian Beadham,Abdelrauof A. Elmanama,Mohammed R. Mattar,James Raftery,Robin G. Pritchard,Adel M. Awadallah,John M. Gardiner
Bioorganic & Medicinal Chemistry Letters. 2014;
[Pubmed] | [DOI]
136 Insight into the cytotoxicity of polynuclear Cu(I) camphor complexes
Tiago A. Fernandes,Filipa Mendes,Alexandra P.S. Roseiro,Isabel Santos,M. Fernanda N.N. Carvalho
Polyhedron. 2014;
[Pubmed] | [DOI]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
   Biological Activity
   Conclusion
    References
    Article Figures

 Article Access Statistics
    Viewed10195    
    Printed152    
    Emailed3    
    PDF Downloaded759    
    Comments [Add]    
    Cited by others 136    

Recommend this journal