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Year : 2014  |  Volume : 6  |  Issue : 2  |  Page : 69-80  

A review exploring biological activities of hydrazones

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India

Date of Submission18-Jul-2013
Date of Decision14-Oct-2013
Date of Acceptance31-Oct-2013
Date of Web Publication20-Mar-2014

Correspondence Address:
Mohammad Mumtaz Alam
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-7406.129170

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The development of novel compounds, hydrazones has shown that they possess a wide variety of biological activities viz. antimicrobial, anticonvulsant, antidepressant, anti-inflammatory, analgesic, antiplatelet, antimalarial, anticancer, antifungal, antitubercular, antiviral, cardio protective etc., Hydrazones/azomethines/imines possess-NHN = CH- and constitute an important class of compounds for new drug development. A number of researchers have synthesized and evaluated the biological activities of hydrazones. This review aims at highlighting the diverse biological activities of hydrazones.

Keywords: Azomethine, biological activity, hydrazones

How to cite this article:
Verma G, Marella A, Shaquiquzzaman M, Akhtar M, Ali MR, Alam MM. A review exploring biological activities of hydrazones. J Pharm Bioall Sci 2014;6:69-80

How to cite this URL:
Verma G, Marella A, Shaquiquzzaman M, Akhtar M, Ali MR, Alam MM. A review exploring biological activities of hydrazones. J Pharm Bioall Sci [serial online] 2014 [cited 2022 Nov 30];6:69-80. Available from:

Hydrazones, related to ketones and aldehydes belong to a class of organic compounds with the structure, R 1 R 2 C = NNH 2 [1] These compounds possess diverse biological and pharmacological properties such as antimicrobial, anti-inflammatory, analgesic, antifungal, anti-tubercular, antiviral, anticancer, antiplatelet, antimalarial, anticonvulsant, cardio protective, antihelmintic, antiprotozoal, [2] anti-trypanosomal, [3] antischistosomiasis etc. [4] These compounds contain C = N bond, which is conjugated with a lone pair of electrons of the functional nitrogen atom. [5] The nitrogen atoms of the hydrazones are nucleophilic and the carbon atom has both electrophilic and nucleophilic nature. [6] The α-hydrogen of hydrazones is more potent than that of acidic ketones.[7] The combination of hydrazones with other functional group leads to compounds with unique physical and chemical character.[8] Owing to their biological and pharmacological properties, they are considered important for the synthesis of heterocyclic compounds. [9]

   Biological Activity Top

Antimicrobial activity

The emerging bacterial resistance causes a widespread problem for the treatment of various infections. Therefore, the search for antimicrobials is a never-ending task. Now-a-days a number of hydrazone derivatives have been developed and evaluated for their antibacterial activity. Aslan et al., [10] investigated the antibacterial activity of sulfonyl derivatives (1). Certain steroidal hydrazines (2, 3) have been synthesized by Khan [11] which possess in-vitro antibacterial activity. Hydrazones bearing imidazoles (4) have been synthesized and screened for antibacterial activity against numerous bacterial strains by Abdel-Wahab et al.[12] Palekar et al., [13] synthesized different thiazolidinone derivatives (5, 6) using hydrazine hydrate and evaluated them for their in-vitro antibacterial activity. Wang et al., [14] synthesized hydrazone derivatives (7) with significant antibacterial activity. Hydrazone derivatives containing transition metal complex (8) were synthesized and evaluated for antimicrobial activity by Babahan et al.[15] Ozkay et al., [16] synthesized novel benzimidazole derivatives bearing hydrazone moiety (9) with antibacterial activity against different bacterial strains. Khalil et al., [17] synthesized hydrazone derivatives (10) and reported them as potential antibacterial agent. Hydrazone derivatives (11) synthesized by Abdel-Aziz and Mekawey [18] exhibited antibacterial activity with minimum inhibitory concentration (MIC) of 75 μg/mL. Good antibacterial activity of hydrazone derivatives (12) was reported by Bawa et al.[19] Hydrazone derivatives (13), synthesized by Sharma et al., [20] exhibited antibacterial activity against various bacterial strains. Antibacterial activity of certain hydrazone derivatives (14) was reported by Kendall et al.[21] Jubie et al. [22] synthesized hydrazone derivatives (15, 16) and reported them as promising antibacterial agents. Govindasami et al. [23] synthesized and evaluated vanillin related hydrazone derivatives for their antibacterial activity. Compounds 17 and 18 exhibited good activity.

Tuberculosis is a chronic, infectious and most prevalent disease all over the world. It is caused by different strains of the Mycobacterium tuberculosis. Lungs, liver and bones are most susceptible to infection. The activity of the newer agents is mostly tested against virulent H37Rv strain. Kamal et al., [24] synthesized nitroheterocyclic based 1, 2, 4-benzothiadizines (19), which exhibited MIC of 1 μg/mL. Raja et al., [25] synthesized hydrazone derivatives (20) and reported to have MIC of 6.25 μg/mL. Telvekar et al., [26] developed benzofuran-3-carbohydrazide derivatives (21) with good anti-tubercular activity. Hydrazone derivatives (22) synthesized by Gemma et al., [27] exhibited MIC of 6.25 μg/mL. Mahajan et al., [28] synthesized ferrocene-based hydrazone derivatives (23) with significant antitubercular activity. 1H-indole-2,3-dione based hydrazones (24), synthesized by Karali et al., [29] exhibited half maximal inhibitory concentration (IC 50 ) of 7.6 μg/mL. Hydrazones (25), synthesized by Eswaran et al., [30] exhibited a MIC of 6.25 μg/mL. Hydrazones (26, 27) synthesized by Imramovský et al., [31] based on isonicotinoylhydrazide, pyrazinamide, p-aminosalicylic acid, ethambutol, and ciprofloxacin exhibited MIC of 0.78 μg/mL and 3.13 μg/mL respectively. Hearn et al., [32] synthesized anti-tubercular agents (28, 29) which showed MIC of 0.06 μg/mL and 0.20 μg/mL respectively. Nayyar and Jain [33] synthesized disubstituted quinolone based hydrazides (30, 31) with good activity profiles. Turan-Zitouni et al., [34] synthesized thiazolyl hydrazones (32) having anti-tubercular activity with MIC of 2.5 μg/mL. 4-(adamantan-1-yl)-2-substituted quinoline based hydrazones (33) synthesized by Nayyar et al., [35] showed MIC of 1.00 μg/mL. Imramovský et al., [31] synthesized isonicotinyl derivatives (34) with a MIC of 3.13 μg/mL.

Fungal infections are generally observed as superficial or systemic infections in humans, animals as well as plants. The development of antifungal agents has surpassed the development of antibacterials. Secci et al., [36] developed novel Hydrazine derivative (35) and evaluated for in-vitro anti-Candidal activity which exhibited MIC of 0.25 μg/mL. Novel hydrazine thiazole derivatives (36) have been synthesized by Maillard et al., [37] and reported to exhibit anti-Candidal activity with MIC of 0.25 μg/mL. Altintop et al., [38] developed, evaluated novel hydrazone derivatives (37) for in-vitro anti-Candidal activity, and reported to have MIC of 0.05 μg/mL. Hydrazide derivatives (38) synthesized by Telvekar et al., [26] exhibited MIC of <15.62 μg/mL. Chimenti et al.[39] synthesized 2-thiazolylhydrazones (39) and reported to have potential activity against various strains of Candida species. Kocyigit-Kaymakcioglu et al. synthesized and evaluated the antifungal activity of various 3-acetyl-2,5-disubstituted-2,3-dihydro-1, 3, 4-oxadiazoles. Out of these, 4-Fluorobenzoic acid ([5-bromothiophen-2-yl] methylene) hydrazide (40) exhibited highest inhibitory activity against Candida albicans, with MIC value of 125 μg/mL. [40]

Virus is a small infectious agent, which can replicate only inside the living cell of an organism. It infects all types of organisms-humans, animals as well as plants. El-Sabbagh and Rady [41] evaluated the antiviral activity of hydrazone derivatives (41) against hepatitis A virus. Tian et al., [42] synthesized hydrazone derivatives (42, 43) as potential targets of human immunodeficiency virus-1 capsid protein. The half maximal effective concentration (EC 50 ) value of the agents was reported to be 0.21 and 0.17 μM respectively [Figure 1].
Figure 1: Structure of hydrazones reported as antimicrobial agents

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Analgesic and anti-inflammatory activity

A number of hydrazone derivatives have been developed to overcome gastrointestinal disturbance and toxicity. Mohamed Eissa et al., [43] developed anthranilic acid derivatives (44) and reported to have significant anti-inflammatory activity. Hydrazones containing 5-methyl-2 benzoxazolinones (45), developed by Salgin-Gökşen et al., [44] were reported to exhibit good analgesic and anti-inflammatory activity. Khan et al., [45] have described the anti-inflammatory activity of hydrazones derivatives of quinoxalinone (46). Rajitha et al., [46] have reported good anti-inflammatory activity of aryl hydrazone derivatives (47). Benzylidene hydrazides (48) with prominent analgesic and anti-inflammatory activity, exhibiting percentage inhibition of 68.66 have been synthesized by Bhandari et al. [47] Gökçe et al., [48] reported the analgesic and anti-inflammatory activity of 6-substituted-3 (2H)-pyridazinone-2-acetyl-2-(p-substituted benzal) hydrazone derivatives (49). Moldovan et al., [49] synthesized various hydrazone derivatives (50) with promising in-vivo anti-inflammatory activity. Kümmerle et al., [50] developed N-acylhydrazone derivatives (51, 52) with ED 50 value of 2.3 and 1.6 mg/kg respectively [Figure 2].
Figure 2: Structure of hydrazones reported as analgesic and anti-inflammatory agents

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Anticancer activity

World Health Organization defines cancer as the rapid creation of abnormal cells that grow beyond their usual boundaries and which can invade adjoining parts of the body and spread to other organs. Dandawate et al., [51] developed plumbagin hydrazone derivatives (53) with high activity against breast cancer. Mohareb and Al-Omran [52] synthesized cyanoacetyl hydrazone with pregnanolone derivatives (54) active against multiple cancer cell lines. Aydın et al., [53] synthesized and evaluated flurbiprofen hydrazide derivatives (55) against ovarian and leukemia cancer cell lines. Cui et al., [54] synthesized acylhydrazones (56) and reported to have potent activity against the human promyelocytic leukemic cells (Hl-60). Al-Said et al., [55] synthesized certain compounds (57) and reported to have in-vitro anticancer activity against human breast cancer cell lines MCF7. Liu et al., [56] synthesized, evaluated acetyl hydrazone derivatives (58) for antitumor activity against A549, HCT11b, HepG2, PC-9 and A375 cell lines with an IC 50 value of 4-17 μM. Aryl hydrazone derivatives (59) synthesized by Vogel et al., [57] were reported to have an IC 50 of 6.7 nM against MDA-MB 231 and MCF-7 breast cancer cell lines. Xu et al., [58] screened hydrazone derivatives (60) for kinase inhibition in different cell lines. Benites et al., [59] synthesized hydrazone derivatives (61) and reported them to have significant antiproliferative activity. Hydrazone derivatives reported by Hayakawa et al., [60] (62, 63, 64) exhibited marked PI3 kinase p110 α inhibition. Zheng et al., [61] synthesized hydrazone derivatives (65) with the propensity to act against A549 lung cancer cell lines. Xia et al., [62] synthesized various hydrazones (66) with IC 50 value of 3.33 μM against A549 lung cancer cell lines. Gürsoy et al., [63] reported the anticancer activity of thiazolohydrazides (67) against prostate cancer. Despaigne et al., [64] have described acetylpyridine and benzoylpyridine derived hydrazones (68, 69) as agents against brain tumor [Figure 3].
Figure 3: Structure of hydrazones reported as anticancer agents

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Central nervous system (CNS) activity

CNS diseases can affect either brain or the spinal cord resulting in psychological and neurological disorder. Hydrazones are reported to have activity against various disorders of CNS. Salgin-Gökşen et al., [65] synthesized benzylidene hydrazone derivatives (70) and screened them for in-vitro monoamine oxidase inhibitory (MAO-B) activity for Parkinson's disease. Novel 2-Methoxy acyl hydrazone derivatives (71) synthesized by Cutshall et al., [66] were evaluated for inhibition of phosphodiasterase 10A (PDE10A), a PDE responsible for neurological and psychological disorders like schizophrenia. Certain anticonvulsant bishydrazones (72) and hydrazones (73) were developed by Kulandasamy et al.[67] de Oliveira et al., [68] synthesized and evaluated the antidepressant activity of hydrazones (74). Gökhan-Kelekçi et al., [69] synthesized hydrazone derivatives (75, 76), reported their selective MAO-B inhibition and hence useful in the treatment of depression [Figure 4].
Figure 4: Structure of hydrazones reported as CNS agents

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Antiprotozoal activity

Protozoa are a diverse group of unicellular eukaryotic organisms affecting human beings, especially in tropical countries. Aryl hydrazone derivatives (77) synthesized by Siddiqui et al., [70] have been evaluated against HM1: IMSS strain of Entamoebica histolytica for anti-amoebic activity and reported to have IC 50 0.13 μM. Gerpe et al., [71] described the anti-Trypanosomal activity of 5-nitrofuran hydrazones (78). Caputto et al., [72] synthesized hydrazine derivatives (79) and reported to have activity against Trypanosoma cruzi (T. cruzi). Carvalho et al., [73] synthesized Cinamic N-acyl hydrazones (80) with good anti-Trypanosomal activity. dos Santos Filho et al., [74] synthesized hydrazone derivatives (81, 82) against T. cruzi. Trypanosomicidal activity of hydrazones (83, 84) has been reported by Porcal et al. [75] Hydrazone derivatives (85) developed by de Aquino et al., [76] have been reported to be useful in infections caused by Toxoplasma gondii. Caputto et al., [77] reported the inhibitory activity of hydrazones (86, 87) against cruzipain-a major cysteine protease of T. cruzi.

Malaria is a widespread infectious disease specifically of the tropics caused by Plasmodium. Antimalarial propensity of hydrazines (88) has been reported by Fattorusso et al.[78] against D10, W2 and 3D7 plasmodial strains with an IC 50 value of 39.2, 79.0 and 11.0 nM respectively. Acharya et al., [79] synthesized hydrazide derivatives (89) with an IC 50 of 160 nM/mL as against 280 nM/mL of the reference chloroquine [Figure 5].
Figure 5: Structure of hydrazones reported as antiprotozoal agents

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Cardio protective activity

Cardiovascular disease is a class of diseases that involve the heart and blood vessels. Despite the extensive research, it still remains the major cause of mortalities world-wide. Bi et al., [80] reported hydrazone derivatives (90) to have potent activity against ischemia-reperfusion induced cardiac infarct size. Leal, et al., [81] synthesized acylhydrazone derivative (91) and reported to have high anti-hypertensive activity.

Antiplatelet activity

Antiplatelet drugs are the agents which decrease platelet aggregation and inhibit thrombus formation. Mashayekhi et al., [82] demonstrated the antiplatelet activity of hydrazone derivatives (92) containing indole moiety. Hydrazone derivatives (93, 94) synthesized by Lima et al., [83] were reported to inhibit platelet aggregation induced by collagen and thrombin [Figure 6].
Figure 6: Structure of hydrazones reported as cardioprotective and antiplatelet agents

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   Conclusion Top

The present review highlights the use of hydrazones as lead for the development of newer compounds. Biological activities of hydrazones include antibacterial, anticonvulsant, analgesic, anti-inflammatory, cardio protective, antiplatelet, anticancer etc., With proper designing, synthesis and structure activity relationship, a number of compounds can be developed with diverse biological activities.

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56 Gallium(III) complexes of aroylhydrazones derived from nicotinic acid hydrazide in solid state and in solution
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Journal of Molecular Structure. 2021; 1227: 129564
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57 Non-covalent interactions abetted supramolecular arrangements of N-Substituted benzylidene acetohydrazide to direct its solid-state network
Muhammad Khalid, Akbar Ali, Muhammad Usman Khan, Muhammad Nawaz Tahir, Anees Ahmad, Muhammad Ashfaq, Riaz Hussain, Sara Figueirêdo de Alcântara Morais, Ataualpa Albert Carmo Braga
Journal of Molecular Structure. 2021; 1230: 129827
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58 Titanium(IV) complex containing ONO-tridentate Schiff base ligand: Synthesis, crystal structure determination, Hirshfeld surface analysis, spectral characterization, theoretical and computational studies
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Journal of Molecular Structure. 2021; 1241: 130653
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59 Quantum chemical modeling, synthesis, spectroscopic (FT-IR, excited States, UV–Vis) studies, FMO, QTAIM, NBO and NLO analyses of two new azo derivatives
Erfu Huo, Siyamak Shahab, Sultan Al Saud, Weiqin Cheng, Peng Lu, Masoome Sheikhi, Radwan Alnajjar, Sadegh Kaviani
Journal of Molecular Structure. 2021; 1243: 130810
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60 In vitro and in silico studies of radical scavenging activity of salicylaldehyde benzoylhydrazones
Nadya G. Hristova-Avakumova, Evgenia P. Valcheva, Neda O. Anastassova, Boryana I. Nikolova-Mladenova, Liliya A. Atanasova, Silvia E. Angelova, Denitsa Y. Yancheva
Journal of Molecular Structure. 2021; 1245: 131021
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61 Ru3+, Mn2+, Co2+, Ni2+, Cu2+, and Zn2+ uni-metallic complexes of 3-(-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl) methylene) hydrazono)indolin-2-one, preparation, structure elucidation and antibacterial activity
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Journal of Molecular Structure. 2021; 1246: 131194
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62 Flavone-based hydrazones as new tyrosinase inhibitors: Synthetic imines with emerging biological potential, SAR, molecular docking and drug-likeness studies
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63 Structural, spectroscopic, quantum chemical, and molecular docking investigation of (E)-N'-(2,5-dimethoxybenzylidene)picolinohydrazide
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Journal of Molecular Structure. 2021; : 132259
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64 Neuroprotective evaluation of novel substituted 1,3,4-oxadiazole and aroylhydrazone derivatives
Valentin R. Karabelyov, Magdalena S. Kondeva-Burdina, Nikolay G. Vassilev, Elena K.-Yovkova, Violina T. Angelova
Bioorganic & Medicinal Chemistry Letters. 2021; : 128516
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65 Synthesis and Cytotoxic Activity of 5a-Pregnanolone Hydrazones
N. Sh. Nadaraia, M. L. Kakhabrishvili, N. N. Barbakadze, V. D. Mshvildadze, K. G. Mulkidzhanyan, A. Pichette
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66 Formation of a new CuII–triazole ester complex from 1,2-cyclohexanedione-bis(p-bromobenzohydrazone) compound as a consequence of copper(II)-catalyzed click reaction
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67 Biologically Active Quinoline-Hydrazone Conjugates as Potential Trypanosoma cruzi DHFR-TS Inhibitors: Docking, Molecular Dynamics, MM/PBSA and Drug-Likeness Studies
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68 Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard’s T and P reagents
Nevena Stevanovic, Paolo Pio Mazzeo, Alessia Bacchi, Ivana Z. Matic, Marija Ðordic Crnogorac, Tatjana Stanojkovic, Miroslava Vujcic, Irena Novakovic, Dušanka Radanovic, Maja Šumar-Ristovic, Dušan Sladic, Bofžidar Cobeljic, Katarina Andelkovic
JBIC Journal of Biological Inorganic Chemistry. 2021; 26(8): 863
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69 N , N -Dialkylhydrazones as Versatile Umpolung Reagents in Enantioselective Anion-Binding Catalysis
Melania Gómez-Martínez, María Carmen Pérez-Aguilar, Dariusz G. Piekarski, Constantin G. Daniliuc, Olga García Mancheño
Angewandte Chemie International Edition. 2021; 60(10): 5102
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70 Iron(III), copper(II), cadmium(II), and mercury(II) complexes of isatin carbohydrazone Schiff base ligand (H 3 L): Synthesis, characterization, X-ray diffraction, cyclic voltammetry, fluorescence, density functional th
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71 N , N -Dialkylhydrazones as Versatile Umpolung Reagents in Enantioselective Anion-Binding Catalysis
Melania Gómez-Martínez, María Carmen Pérez-Aguilar, Dariusz G. Piekarski, Constantin G. Daniliuc, Olga García Mancheño
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72 Synthesis and characterization of novel tricyanofuran hydrazone probe: solvatochromism, density-functional theory calculation and selective fluorescence, and colorimetric determination of iron (III)
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73 Ammonium-Charged Sterically Hindered Phenols with Antioxidant and Selective Anti-Gram-Positive Bacterial Activity
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74 1,3-Oxazole-isoniazid hybrids: Synthesis, antitubercular activity, and their docking studies
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75 N -Trifluoromethyl Hydrazines, Indoles and Their Derivatives
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76 Facile Ultrasound-Based Synthesis, SC-XRD, DFT Exploration of the Substituted Acyl-Hydrazones: An Experimental and Theoretical Slant towards Supramolecular Chemistry
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77 N -Trifluoromethyl Hydrazines, Indoles and Their Derivatives
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78 Synthesis and antimycobacterial evaluation of pyridinyl- and pyrazinylhydrazone derivatives
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79 Synthesis and antiproliferative activity of salicylidenehydrazones based on indole-2(3)-carboxylic acids
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80 Synthesis of Ag-AgCl nanoparticles capped by calix[4]resorcinarene-mPEG conjugate and their antimicrobial activity
Alina M. Shumatbaeva, Julia E. Morozova, Yana V. Shalaeva, Alina F. Saifina, Aidar T. Gubaidullin, Victor V. Syakaev, Anastasia S. Sapunova, Alexandra D. Voloshina, Irek R. Nizameev, Marsil K. Kadirov, Kseniya S. Bulygina, Vasily M. Babaev, Igor S. Antipin
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81 Zn(II) complexes of (E)-4-(2-(pyridin-2-ylmethylene)hydrazinyl)quinazoline in combination with non-steroidal anti-inflammatory drug sodium diclofenac: Structure, DNA binding and photo-cleavage studies, antioxidant activity and interaction with albumin
Chrisoula Kakoulidou, Panagiotis S. Gritzapis, Antonios G. Hatzidimitriou, Konstantina C. Fylaktakidou, George Psomas
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82 Novel hydrazono-hydrazonoyl chlorides containing pyrazole moiety for concurrent dyeing and practical finishing of cotton fabrics
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Journal of Materials Research and Technology. 2020; 9(4): 7380
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83 Synthesis and characterization of (E)-2-(1-hydrazonoethyl)-4,5-dimethylphenol from 2-hydroxy-4,5-dimethylacetophenone
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Journal of Chemical Sciences. 2020; 132(1)
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84 Hydrazone comprising compounds as promising anti-infective agents: chemistry and structure-property relationship
P.C. Sharma, D. Sharma, A. Sharma, N. Saini, R. Goyal, M. Ola, R. Chawla, V.K. Thakur
Materials Today Chemistry. 2020; 18: 100349
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85 Protonation of hydrazones derived from pyridoxal 5'-phosphate: Thermodynamic and structural elucidation
G.A. Gamov, A.N. Meshkov, M.N. Zavalishin, A. Yu. Khokhlova, A.V. Gashnikova, V.V. Aleksandriiskii, V.A. Sharnin
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86 Synthesis of half sandwich platinum group metal complexes containing pyridyl benzothiazole hydrazones: Study of bonding modes and antimicrobial activity
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Journal of Organometallic Chemistry. 2020; 914: 121225
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87 Grinding induced catalyst free, multicomponent synthesis of Indoloindole pyrimidine
Suresh Kumar Maury, Savita Kumari, Ambuj Kumar Kushwaha, Arsala Kamal, Himanshu Kumar Singh, Dhirendra Kumar, Sundaram Singh
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88 Synthesis, molecular structure, spectroscopic and theoretical investigation of 5-chlorosalicylaldehyde-2,4-dinitrophenylhydrazone
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Journal of Molecular Structure. 2020; 1205: 127589
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89 Microwave and conventional synthesis of ester based dicationic pyridinium ionic liquids carrying hydrazone linkage: DNA binding, anticancer and docking studies
Salsabeel A. Al-Sodies, Mohamed Reda Aouad, Saleh Ihmaid, Ateyatallah Aljuhani, Mouslim Messali, Imran Ali, Nadjet Rezki
Journal of Molecular Structure. 2020; 1207: 127756
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90 Copper(II) complexes of aroylhydrazones: Preparation and structural characterization
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91 Spectroscopic, crystal structural, theoretical and biological studies of phenylacetohydrazide Schiff base derivatives and their copper complexes
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Journal of Molecular Structure. 2020; 1208: 127860
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92 Synthesis and X-ray crystal structures of two different zinc (II) complexes of N,N'-cyclohexane-1,2-diylidene-bis(4-fluorobenzoylhydrazide) based on zinc salt effect
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Journal of Molecular Structure. 2020; 1217: 128387
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93 Synthesis, experimental and theoretical characterization of (E)-2-((2,3-dimethylphenyl)amino)-N’-(furan-2-ylmethylene)benzohydrazide
Mustafa R. Albayati, Sevgi Kansiz, Hassane Lgaz, Savas Kaya, Necmi Dege, Ismat H. Ali, Rachid Salghi, Ill-Min Chung
Journal of Molecular Structure. 2020; 1219: 128518
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94 Physicochemical characterization of antimony(III), copper(II) and silver(I) complexes with 4-nitroimidazole-derived hydrazones
Ana P.A. Oliveira, Micael Ferencs, Vivianne O. Azevedo, Renata Diniz, Sonia R.W. Louro, Odivaldo C. Alves, Heloisa Beraldo
Journal of Molecular Structure. 2020; 1222: 128874
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95 An Experimental and Computational Exploration on the Electronic, Spectroscopic, and Reactivity Properties of Novel Halo-Functionalized Hydrazones
Akbar Ali, Muhammad Khalid, Muhammad Abdul Rehman, Farooq Anwar, Hafiz Zain-Ul-Aabidin, Muhammad Nadeem Akhtar, Muhammad Usman Khan, Ataualpa Albert Carmo Braga, Mohammed A. Assiri, Muhammad Imran
ACS Omega. 2020; 5(30): 18907
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96 Catalyst-Free One-Pot Three-Component Synthesis of 4-Hydroxy-3-pyrazolylcoumarins in Ethanol at Room Temperature: Enolisable Aroylhydrazones as Efficient Ambident Nucleophile
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ACS Sustainable Chemistry & Engineering. 2020; 8(1): 403
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97 Enantiotropic Transformation of Carbethoxyhydrazones of Acetophenones
E. A. Popova, O. V. Stepanova, V. V. Bessonov, G. D. Nepochatyi, L. M. Pevzner, M. L. Petrov
Russian Journal of General Chemistry. 2020; 90(2): 311
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98 Two new zinc(II) and mercury(II) complexes based on N,N'-(cyclohexane-1,2-diylidene)bis(4-fluorobenzohydrazide): synthesis, crystal structures and antibacterial activities
Al-Ameen Bariz OmarAli, Ahmed Jasim M. Al-Karawi, Adil A. Awad, Necmi Dege, Sevgi Kansiz, Erbil Agar, Zaman Ahmed Hussein, Iman Rajab Mohammed
Acta Crystallographica Section C Structural Chemistry. 2020; 76(5): 476
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99 Novel multifunctional and multitarget homo- (Fe2) and heterobimetallic [(Fe,M) with M = Re or Mn] sulfonyl hydrazones
Yosselin Huentupil, Patricio Chung, Néstor Novoa, Rodrigo Arancibia, Pascal Roussel, Juan Oyarzo, A. Hugo Klahn, Carlos Silva, Carme Calvis, Ramon Messeguer, Ramón Bosque, Concepción López
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100 Microwave-Assisted Synthesis, Antioxidant and Toxicological Evaluation of a Hydrazone, 1-(4-chlorobenzylidene)-2-phenylhydrazine
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101 Heterocyclization of 2-(2-phenylhydrazono)cyclohexane-1,3-dione to Synthesis Thiophene, Pyrazole and 1,2,4-triazine Derivatives with Anti-Tumor and Tyrosine Kinase Inhibitions
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Anti-Cancer Agents in Medicinal Chemistry. 2020; 20(10): 1209
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102 1,2,4-Triazole-Based Hybrid Heterocyclic Carbaldehyde Hydrazones and Their Effect on DNA Methylation Level
T. R. Hovsepyan, M. R. Hakobyan, R. E. Muradyan, L. E. Nersesyan, A. S. Aharonyan, I. S. Danielyan, N. S. Minasyan, A. A. Harutyunyan
Russian Journal of Organic Chemistry. 2020; 56(12): 2137
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103 Synthesis and biological evaluation of 2-(4-methylsulfonyl phenyl) indole derivatives: multi-target compounds with dual antimicrobial and anti-inflammatory activities
Ahmed M. M. Shaker, Eman K. A. Abdelall, Khaled R. A. Abdellatif, Hamdy M. Abdel-Rahman
BMC Chemistry. 2020; 14(1)
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104 A study of antituberculosis activities and crystal structures of (E)-2-[2-(arylidene)hydrazinyl]pyrimidine and (E)-N 1-(arylidene)pyrimidine-2-carbohydrazide derivatives
Alessandra C. Pinheiro, Thaís C. M. Nogueira, Cristiane França da Costa, Cristina Lourenço, John N. Low, James L. Wardell, Solange M. S. V. Wardell, Marcus V. N. de Souza
Zeitschrift für Naturforschung B. 2020; 75(12): 1011
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105 Green Synthesis, SC-XRD, Non-Covalent Interactive Potential and Electronic Communication via DFT Exploration of Pyridine-Based Hydrazone
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106 Computer-Aided Design, Synthesis, and Antiviral Evaluation of Novel Acrylamides as Potential Inhibitors of E3-E2-E1 Glycoproteins Complex from Chikungunya Virus
Gabriel Felipe Silva Passos, Matheus Gabriel Moura Gomes, Thiago Mendonça de Aquino, João Xavier de Araújo-Júnior, Stephannie Janaina Maia de Souza, João Pedro Monteiro Cavalcante, Elane Conceição dos Santos, Ênio José Bassi, Edeildo Ferreira da Silva-Júnior
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107 Green Synthesis of new heterocyclic hydrazones, spectroscopic characterization
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108 Novel 4-methoxynaphthalene-N-acylhydrazones as potential for paracoccidioidomycosis and tuberculosis co-infection
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109 The Use of Hydrazones for Biomedical Applications
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110 Synthesis and preliminary screening for the biological activity of some steroidal ?4-unsaturated semicarbazone derivatives
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111 Photoredox Decarboxylative C(sp3)–N Coupling of a-Diazoacetates with Alkyl N-Hydroxyphthalimide Esters for Diversified Synthesis of Functionalized N-Alkyl Hydrazones
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112 Exploration of C–H Transformations of Aldehyde Hydrazones: Radical Strategies and Beyond
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113 Continuous Flow a-Arylation of N,N-Dialkylhydrazones under Visible-Light Photoredox Catalysis
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114 Perfluoroalkylation of Aryl-N,N-dimethyl Hydrazones Using Hypervalent Iodine(III) Reagents or Perfluoroalkyl Iodides
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115 Chiral lactic hydrazone derivatives as potential bioactive antibacterial agents: Synthesis, spectroscopic, structural and molecular docking studies
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Journal of Molecular Structure. 2017; 1128: 391
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116 Copper-Catalyzed Transformation of Hydrazones into Halogenated Azabutadienes, Versatile Building Blocks for Organic Synthesis
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117 Schiff bases in medicinal chemistry: a patent review (2010-2015)
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118 Synthesis of bis[9-hydroxy-1-{N-hydroxy-2-[(2,4-dinitrophenyl)hydrazinylidene]alkanimidoyl}]-1,9-dihydro[C60-I h][5,6]fullerenes
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119 The mutagenic mechanism of oxygenated alkylhydrazones occurs through alkyl radicals and alkyldiazonium ions
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120 Stereoselective, solvent free, highly efficient synthesis of aldo- and keto-N-acylhydrazones applying grindstone chemistry
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Green Chem.. 2017;
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121 A detailed experimental and computational study of monocarbohydrazones
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122 Oxorhenium(V) complexes with bidentate carbohydrazide Schiff bases: synthesis, characterization and DNA interaction studies
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123 Rhenium(I) complexes with bidentate carbohydrazide Schiff bases: Synthesis, characterization, computational and DNA interaction studies
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124 New hydrazine and hydrazide quinoxaline 1,4-di-N-oxide derivatives: In silico ADMET, antiplasmodial and antileishmanial activity
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125 Synthesis and biological evolution of hydrazones derived from 4-(trifluoromethyl)benzohydrazide
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126 In vitro and in silico evaluation of chromene based aroyl hydrazones as anticonvulsant agents
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127 Synthesis, antiprotozoal activity and cytotoxicity in U-937 macrophages of triclosan–hydrazone hybrids
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128 Synthesis, Molecular Modeling, and Evaluation of Novel Sulfonylhydrazones as Acetylcholinesterase Inhibitors for Alzheimeræs Disease
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129 A Copper-Benzotriazole-Based Coordination Polymer Catalyzes the Efficient One-Pot Synthesis of (N' -Substituted)-hydrazo-4-aryl-1,4-dihydropyridines from Azines
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161 Insight into the cytotoxicity of polynuclear Cu(I) camphor complexes
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