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REVIEW ARTICLE
Year : 2014  |  Volume : 6  |  Issue : 2  |  Page : 81-85

Pros and cons of phospholipid asymmetry in erythrocytes

Aiswarya Sathi1, Vidya Viswanad1, TP Aneesh2, B Anil Kumar3
1 Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwavidyapeetham University, AIMS Health Science Campus, Cochin, Kerala, India
2 Department of Pharmaceutical Analysis, Amrita School of Pharmacy, Amrita Vishwavidyapeetham University, AIMS Health Science Campus, Cochin, Kerala, India
3 Department of Pharmacology, Amrita School of Pharmacy, Amrita Vishwavidyapeetham University, AIMS Health Science Campus, Cochin, Kerala, India

Correspondence Address:
Vidya Viswanad
Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwavidyapeetham University, AIMS Health Science Campus, Cochin, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-7406.129171

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Phospholipids of erythrocyte are found as bilayer with choline containing phospholipid like phosphatidyl choline and sphingomylein in the outer layer and amine containing phospholipid like phosphatidyl ethanolamine and phosphatidyl serine in the inner layer. This arrangement is known as phospholipid asymmetry. Lipid asymmetry is maintained throughout the entire life span of red blood cell and is disturbed when cells enter into the stage of apoptosis. We here discuss some of the conditions in which phospholipid asymmetry of erythrocyte is maintained and disturbed and the various detection methods to check the distortion phospholipid asymmetry of it.


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