Journal of Pharmacy And Bioallied Sciences
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Year : 2014  |  Volume : 6  |  Issue : 5  |  Page : 165-170

Administration of bisphosphonate (ibandronate) impedes molar tooth movement in rabbits: A radiographic assessment

1 Department of Orthodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences, Dilshuknagar, Hyderabad, Andhra Pradesh, India
2 Department of Orthodontics, JKKN Dental College, Komarapalyam, Namakkal, India
3 Department of Orthodontics, G. Pulla Reddy Dental College and Hospital, Kurnool, Andhra Pradesh, India
4 Department of Orthodontics Rajah Muthiah Dental College, Annamalai University, Chidambaram, Tamilnadu, India

Correspondence Address:
Dr. K Raja Sigamani
Department of Orthodontics Rajah Muthiah Dental College, Annamalai University, Chidambaram, Tamilnadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-7406.137440

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Introduction: Bisphosphonate (Bp)-ibandronate is a pharmacological agent, exhibits antiosteoclastic or antiresorptive activity and used to treat osteolytic or osteopenic disorders. BP-ibandronate may also interfere during orthodontic tooth movement. The aim of this study was to examine the influence of locally administered Bp-ibandronate on experimental tooth movement in rabbits. Materials and Methods: Twenty rabbits were divided into two groups- "10" served as Group-1 (control) and other "10" as Group-2 (experimental). Both groups received nickel-titanium closed coil springs with 100 g force between mandibular molar and incisors. Group-1 animals received 1 ml normal saline and Group-2 animals received ibandronate solution (0.3 mg/kg body weight) locally, mesial to the mandibular molar on the 1 st , 7 th , and 14 th day of the experiment. A total of "40" lateral cephalograms were taken from both groups on the 1 st and 21 st day using a digital X-ray unit (Siemens X-ray systems, 300 mA Pleomophos analog, 2008, Germany). Individually, each animal's radiograph was traced manually and superimposed. The molar tooth movement was measured with the help of a standard metric scale. Results: The Student's t-test has been done to compare the mean values of Group-1 (4.650 ± 0.363) and Group-2 (2.030 ± 0.291) and the difference was statistically significant (P < 0.001). Conclusion: The retarded molar tooth movement was noticed in local drug administered rabbits, which could be beneficial in orthodontics to control the undesired tooth movement.

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