Serum fructosamine a better indicator than glycated hemoglobin for monitoring gestational diabetes mellitus

S Ayyappan; Sachu Philips; C Kishore Kumar; V Vaithiyanandane; C Sasikala

doi:10.4103/0975-7406.155786

Journal of Pharmacy And Bioallied Sciences

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MEDICAL SCIENCE - RESEARCH ARTICLE

Year : 2015 | Volume : 7 | Issue : 5 | Page : 32-34

Serum fructosamine a better indicator than glycated hemoglobin for monitoring gestational diabetes mellitus

S Ayyappan¹, Sachu Philips¹, C Kishore Kumar², V Vaithiyanandane³, C Sasikala⁴
¹ Department of Biochemistry, Vivekanandha Dental College for Women, Tirchengodu, Namakkal, Tamil Nadu, India
² Department of Physiology, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, Affiliated to Bharath University, Chennai, Tamil Nadu, India
³ Department of Physiology, Vivekanandha Dental College for Women, Tirchengodu, Namakkal, Tamil Nadu, India
⁴ Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, Affiliated to Bharath University, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. C Kishore Kumar
Department of Physiology, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, Affiliated to Bharath University, Chennai, Tamil Nadu
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/0975-7406.155786

Gestational Diabetes mellitus is the condition of glucose intolerance that begins during pregnancy which is associated with both fetal and maternal complications. The measurement of serum fructosamine and glycated hemoglobin in normal and diabetic pregnancy used to investigate the influence of maternal and gestational age on concentrations of glycated proteins in serum and used to evaluate the patient's treatment. This study was done to measure the level of serum fructosamine and Glycated hemoglobin (HbA1c) in Gestational Diabetes mellitus (GDM) patients and to compare with pregnant women without diabetes and healthy non-pregnant adults, to determine the pattern of change in serum fructosamine, influence of serum fructosamine and HbA1c values and to evaluate the efficacy of patient's treatment. In this study the level of fructosamine was positively correlated to HbA1c during 2 ^nd trimesters of gestational period, implying that the level of fructosamine can be used to screen Gestational diabetes mellitus. Correlation of glycated hemoglobin values with serum fructosamine measurements in the accurate determination of glycaemic control provides confirmation of the utility of fructosamine measurement.

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