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Year : 2020  |  Volume : 12  |  Issue : 4  |  Page : 428-435

Development and validation of a questionnaire on knowledge, attitude, and perception towards allergic reactions of paracetamol

1 Department of Community and Pharmacy Practice, Faculty of Pharmacy, Cyberjaya University College of Medical Sciences, Lot 3410 Jalan Teknokrat 3, Cyberjaya 63000, Selangor, Malaysia
2 Faculty of Pharmacy, Universiti Sultan Zainal Abidin (UniSZA), Besut Campus, 22200 Besut, Terengganu, Malaysia
3 Social and Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia

Correspondence Address:
Dr. Zalina Zahari
Faculty of Pharmacy, Universiti Sultan Zainal Abidin (UniSZA), Besut Campus, 22200 Besut, Terengganu.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JPBS.JPBS_247_19

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Introduction: National Pharmaceutical Regulatory Agency, Ministry of Health Malaysia has received 1018 adverse drug reaction reports related to paracetamol with 1972 adverse events from the year 2000 to February 2015. Serious skin reactions including Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis, and acute generalized exanthematous pustulosis may develop as a result of allergic reactions of paracetamol. This study aimed to develop and validate a questionnaire regarding Knowledge, Attitude, and Perception towards Allergic Reactions of Paracetamol (KAP-ARP) among the general population. Materials and Methods: Content and face validity of the KAP-ARP were determined by four experts and 20 respondents, respectively. A questionnaire with 36 items, consisting of 16 Knowledge, 9 Attitude, and 11 Perception items, was distributed to 177 respondents. Exploratory factor analysis (EFA) was performed for construct validity. Cronbach’s alpha was used to determine the reliability of the questionnaire. Results: EFA constructed 13 Knowledge, 8 Attitude, and 8 Perception items. The final KAP-ARP questionnaire is reliable based on its internal consistency reliability (Knowledge: α = 0.78; Attitude: α = 0.63; Perception: α = 0.70). Conclusion: A valid and reliable questionnaire that is useful for measuring KAP-ARP among the general population has been developed.

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