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Year : 2021  |  Volume : 13  |  Issue : 4  |  Page : 394-400

Impact of treatment with metformin in comparison with insulin in gestational diabetes in libyan population a randomized controlled study

1 Department of Obstetrics and Gynaecology, Faculty of medicine, Benghazi University, Benghazi, Libya
2 Department of Biochemistry, Faculty of medicine, Benghazi University, Benghazi, Libya
3 Department of Genetics, School of Medicine, St. Matthews University, Grand Cayman, Cayman Islands

Correspondence Address:
Dr. Jagannadha Rao Peela
Department of Genetics, School of Medicine, School of Medicine, St Matthews University, Leeward 3, Regatta Office Park, KY1-1204, Grand Cayman
Cayman Islands
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jpbs.jpbs_168_21

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Background: The aim of this study was the comparison of the glycemic control and maternal outcomes in women affected with gestational diabetes mellitus (GDM) managed with metformin versus insulin. Materials and Methods: The participants included in this study were 140 women diagnosed with GDM. They were randomized into two groups, women included in the first group were treated with metformin and the women of the second group were managed with insulin. Results: The glycemic control was similar in both the treatment arms and the only noteworthy difference was found in the mean fasting blood glucose, which was significantly higher in the women receiving insulin as compared to the women receiving metformin. There were no substantial differences in the maternal outcome with the use of metformin compared to insulin in women with GDM. Conclusion: The incidence of operative delivery was higher in metformin-treated group, whereas the hospital admission rate was considerably elevated in insulin-treated group.

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