Regenerative endodontic therapy in the management of nonvital immature permanent teeth: A systematic review and meta-analysis

Izaz Shaik; Malti Tulli; Priyanka Unnam; Sangeetha Karunakaran; Durga Susmitha Vaddi; Rafiya Jabeen; Rahul Vinay Chandra Tiwari

doi:10.4103/jpbs.JPBS_807_20

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REVIEW ARTICLE

Year : 2021 | Volume : 13 | Issue : 5 | Page : 36-42

Regenerative endodontic therapy in the management of nonvital immature permanent teeth: A systematic review and meta-analysis

Izaz Shaik¹, Malti Tulli², Priyanka Unnam³, Sangeetha Karunakaran⁴, Durga Susmitha Vaddi⁵, Rafiya Jabeen⁶, Rahul Vinay Chandra Tiwari⁷
¹ DMD Student, Rutgers School of Dental Medicine, Newark, New Jersey, USA
² Dental Surgeon, Guru Nanak Dev Dental College and Research Institutes, Sunam, Punjab, India
³ Dental Surgeon, Narayana Dental College and Hospital, Nellore, Tamil Nadu, India
⁴ Dental Surgeon, Sri Ramakrishna Dental College and Hospital, Coimbatore, Tamil Nadu, India
⁵ Dental Surgeon, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India
⁶ Dental Surgeon, AME'S Dental College, Raichur, Karnataka, India
⁷ Department of OMFS, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India

Correspondence Address:
Izaz Shaik
Rutgers School of Dental Medicine, Newark, New Jersey
USA

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/jpbs.JPBS_807_20

This meta-analysis is intended to evaluate the reliability of evidences published in current regenerative endodontic publications in a critical way. This meta-analysis is used to summarize and analyze the various clinical and radiographic findings associated with nonvital immature permanent teeth which have been treated with regenerative endodontic techniques. We also intend to significantly evaluate the worth of facts provided in the previous published literature. A structured electronic search by authors was undertaken in August 2020 using MEDLINE and PubMed search engine. The chosen parameters studied in this systematic review were presented in flowcharts and were summarized. We observed a good accomplishment rates in terms of survival of the treated tooth and also in resolution of any associated pathology in the apical areas; on contrary, our results in relation to apex closure along with constant root development, our findings from various studies were quiet variable. Regenerative endodontic procedures are constantly being restructured and enhanced to benefit present-day dentistry in all likely ways. Still, many factors that are important for the success of regenerative endodontic treatment outcomes still remain unexplained. There are still numerous gaps in our expertise at the present stage of this study.

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