Assessment of growth factors with three different platelet preparations, namely platelet-rich fibrin, platelet-rich plasma, and lyophilized platelet: An In vitro study

R Hariprasad; TL Suganya; Serin Sarah John; P Rajesh Raj; Feby kuriakose; VN Anoop

doi:10.4103/jpbs.jpbs_358_21

Journal of Pharmacy And Bioallied Sciences

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ORIGINAL ARTICLE

Year : 2021 | Volume : 13 | Issue : 6 | Page : 1696-1699

Assessment of growth factors with three different platelet preparations, namely platelet-rich fibrin, platelet-rich plasma, and lyophilized platelet: An In vitro study

R Hariprasad¹, TL Suganya², Serin Sarah John², P Rajesh Raj³, Feby kuriakose⁴, VN Anoop⁵
¹ Full Time Specialist in Endodontics, Department of Dentistry, Employees State Insurance Corporation Hospital, Ezhukone, Kollam, Kerala, India
² Senior Lecturer, Department of Conservative Dentistry and Endodontics, Rajas Dental College, Dr MGR Medical University, Kavalkinaru, Tamilnadu, India
³ Consultant in Oral Medicine Diagnosis and Radiology, Karunya Dental Clinics, Pulincunnu, Kavalam, Thuruthy. Kottayam District, Kerala, India
⁴ Assistant Professor, Department of Conservative Dentistry and Endodontics, Mar Baselios Dental College, Kothamangalam. Affiliated to KUHS (Kerala university of health sciences), Kerala, India
⁵ Senior lecturer, Department of Conservative Eentistry and Endodontics, Noorul Islam College of Dental Sciences, Aralumoodu, Kerala, India

Correspondence Address:
R Hariprasad
Department of Dentistry, Employees State Insurance Corporation Hospital, Ezhukone, Kollam, kerala
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/jpbs.jpbs_358_21

Assessment of growth factors with three different platelet preparations namely platelet rich fibrin, platelet rich plasma and lyophilized platelet-An invitro study Abstract Enhancing wound healing with patients own blood, particularly the platelet preparations have gained more popularity recently. These platelets excrete large amount of growth factors and cytokines that are associated with the healing process and regeneration. Even though these platelet concentrates are widely used in various forms, the mechanism behind that remains unclear. Therefore, this study aims at investigating the levels of growth factors in three different platelet preparations namely platelet rich plasma (PRP), platelet rich fibrin (PRF) and lyophilized platelets. Materials and Methods Autologous blood for preparing the platelet preparations was obtained from healthy donors aged between 25 to 35 years. The samples were then divided into three experimental groups. The preparation of PRP was done with the addition of anticoagulant and the PRF is prepared without adding it. The platelet counts in the blood were analyzed and the growth factors were quantitatively measured using ELISA reader. The statistical analysis was performed by using the Chi square test. Results In the quantitative analysis of growth factors LPL showed significant increase of the liberation of growth factors compared to PRP and PRF. Conclusions With the various recent advances in technologies for preparing these platelet concentrates this can be widely used in clinical practice more accurate in the future.

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