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REVIEW ARTICLE
Year : 2022  |  Volume : 14  |  Issue : 2  |  Page : 81-92

Scoping review of six retrospective studies: risk factors associated with the case fatality rate of people infected with Coronavirus (COVID-19)


1 Program of Clinical Pharmacy, College of Pharmacy, Al Ain University, Al Ain, UAE
2 Program of Clinical Pharmacy, College of Pharmacy, Al Ain University, Abu Dhabi Campus; AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi, United Arab Emirates
3 Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University; Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, UAE
4 Program of Clinical Pharmacy, College of Pharmacy, Al Ain University, Abu Dhabi Campus, UAE
5 College of Pharmacy, Gulf Medical University, Ajman, UAE
6 Department of Clinical Pharmacy, College of Pharmacy, Taif University, Saudi Arabia
7 New Medical Center (NMC), Abu Dhabi, UAE
8 Clinical Pharmacy Department, College of Pharmacy, Al Ain University, Al Ain Campus, United Arab Emirates; Clinical Pharmacy Department, College of Pharmacy, Al-Azhar University, Cairo, Egypt
9 Department of Medical Imaging and Radiation Sciences, Monash University, Melbourne, Australia
10 Clinical Pharmacy, College of Pharmacy, Riyadh Elm University Riyadh, Saudi Arabia
11 Ambulatory Healthcare Services, Academic Affairs, Abu Dhabi Health Services (SEHA), UAE
12 Clinical Pharmacist, Omdurman Islamic University, Omdurman, Sudan
13 Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, Sharjah University, Sharjah, UAE
14 Department of Pharmacy Practice and Pharmacotherapeutics, Faculty of Pharmacy, University of Sharjah, United Arab Emirates

Correspondence Address:
Prof. Asim Ahmed Elnour
Program of Clinical Pharmacy, College of Pharmacy, Al Ain University, Abu Dhabi campus, Abu Dhabi-United Arab Emirates. AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi
United Arab Emirates
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jpbs.jpbs_460_21

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Background: It would be rational to describe the pattern of the clinical characteristics of the survivors and the nonsurvivors during the critical intensive-infection era of coronavirus disease 2019 (COVID-19). The explicit objective of the current scoping review was to delineate the predictive risk factors associated with case fatality rate (CFR). Methods: Six retrospective studies of subjects infected with COVID-19 published between December 1, 2020, and March 30, 2020, describing nonsurvivors in Wuhan/Hubei, China, were identified. Results: There were 1769 subjects with a mean age of 52 years, and 65.9% were male. The highest comorbidity reported was cardiovascular diseases at 22.2% (393/1769). The overall number of cases admitted to the intensive care unit was 228 (12.9%). The reported overall CFR was 7.7% (136/1769), with the highest at 28.2% (54/191), and the lowest at 1.4% (15/1099). The mean duration of onset until death for nonsurvivors was 15.3 days. Conclusion: We have found that older age, male gender, the longer duration from onset till death (days), development of acute respiratory distress syndrome/shock, preexisting diabetes, and preexisting cardiovascular diseases were the major risk factors associated with high CFR.


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