Journal of Pharmacy And Bioallied Sciences

SYMPOSIUM
Year
: 2010  |  Volume : 2  |  Issue : 3  |  Page : 189--196

Radiation-induced biomarkers for the detection and assessment of absorbed radiation doses


Sudha Rana1, Raj Kumar1, Sarwat Sultana2, Rakesh Kumar Sharma1 
1 Division of CBRN Defence, Institute of Nuclear Medicine and Allied Sciences, Brig. S. K. Mazumdar Marg, Delhi - 110 054, India
2 Department of Medical Elementology and Toxicology, Jamia Hamdard, Hamdard Nagar, New Delhi - 110 062, India

Correspondence Address:
Rakesh Kumar Sharma
Division of CBRN Defence, Institute of Nuclear Medicine and Allied Sciences, Brig. S. K. Mazumdar Marg, Delhi - 110 054
India

Radiation incident involving living organisms is an uncommon but a very serious situation. The first step in medical management including triage is high-throughput assessment of the radiation dose received. Radiation exposure levels can be assessed from viability of cells, cellular organelles such as chromosome and different intermediate metabolites. Oxidative damages by ionizing radiation result in carcinogenesis, lowering of the immune response and, ultimately, damage to the hematopoietic system, gastrointestinal system and central nervous system. Biodosimetry is based on the measurement of the radiation-induced changes, which can correlate them with the absorbed dose. Radiation biomarkers such as chromosome aberration are most widely used. Serum enzymes such as serum amylase and diamine oxidase are the most promising biodosimeters. The level of gene expression and protein are also good biomarkers of radiation.


How to cite this article:
Rana S, Kumar R, Sultana S, Sharma RK. Radiation-induced biomarkers for the detection and assessment of absorbed radiation doses.J Pharm Bioall Sci 2010;2:189-196


How to cite this URL:
Rana S, Kumar R, Sultana S, Sharma RK. Radiation-induced biomarkers for the detection and assessment of absorbed radiation doses. J Pharm Bioall Sci [serial online] 2010 [cited 2022 Dec 7 ];2:189-196
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2010;volume=2;issue=3;spage=189;epage=196;aulast=Rana;type=0