Journal of Pharmacy And Bioallied Sciences

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 2  |  Issue : 4  |  Page : 321--324

Transdermal drug delivery of labetalol hydrochloride: Feasibility and effect of penetration enhancers


Saqib Zafar1, Asgar Ali2, Mohammed Aqil2, Abdul Ahad2 
1 Abbott Vascular, New Friend's Colony Okhla, New Delhi - 110 025, India
2 Faculty of Pharmacy, Hamdard University, New Delhi - 110 062, India

Correspondence Address:
Saqib Zafar
Abbott Vascular, New Friend«SQ»s Colony Okhla, New Delhi - 110 025
India

Objectives : The objective of this study is to investigate the feasibility of transdermal drug delivery of Labetalol Hydrochloride (LHCl) and to study the effect of different penetration enhancers on the skin permeability of LHCl. Methods : The permeability experiments were conducted using a horizontal glass diffusion cell with a diffusional area of 2.37 cm­2 on albino rat skin. The effect of various penetration enhancers namely turpentine oil, dimethyl formamide (DMF), menthol, dimethyl sulfoxide, pine oil, and 2-pyrollidone, and the effect of the concentration of drug and enhancer in the donor phase on the skin permeability of LHCl was studied. Results : The apparent partition coefficient of the drug was found to be 6.95, suggesting it to be a lipophilic drug. The preliminary skin permeation studies revealed that the permeation of LHCL through albino rat skin was moderate (Kp = 6.490 Χ 10 -2 cm hr -1 ) from isotonic phosphate buffer of pH 7.4. An appreciable increase in the LHCl permeability coefficient was observed on using a co-solvent (ethanol 95%) with the penetration enhancers in the donor phase. DMSO (10% v/v) was found to be the most effective enhancer for Labetalol hydrochloride (Enhancement Factor = 1.165). An increase in the concentration of drug and enhancer in the donor cell accentuated the permeability coefficient of LHCl. Conclusions : It was concluded that LHCl could be delivered via the dermal route with the use of 10% DMSO as the penetration enhancer.


How to cite this article:
Zafar S, Ali A, Aqil M, Ahad A. Transdermal drug delivery of labetalol hydrochloride: Feasibility and effect of penetration enhancers.J Pharm Bioall Sci 2010;2:321-324


How to cite this URL:
Zafar S, Ali A, Aqil M, Ahad A. Transdermal drug delivery of labetalol hydrochloride: Feasibility and effect of penetration enhancers. J Pharm Bioall Sci [serial online] 2010 [cited 2022 Jul 7 ];2:321-324
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2010;volume=2;issue=4;spage=321;epage=324;aulast=Zafar;type=0