Journal of Pharmacy And Bioallied Sciences

SYMPOSIUM
Year
: 2011  |  Volume : 3  |  Issue : 1  |  Page : 39--59

Differential scanning calorimetry: An invaluable tool for a detailed thermodynamic characterization of macromolecules and their interactions


Michael H Chiu, Elmar J Prenner 
 Department of Biological Sciences, University of Calgary, T2N 1N4 Calgary, AB, Canada

Correspondence Address:
Elmar J Prenner
Department of Biological Sciences, University of Calgary, T2N 1N4 Calgary, AB
Canada

Differential Scanning Calorimetry (DSC) is a highly sensitive technique to study the thermotropic properties of many different biological macromolecules and extracts. Since its early development, DSC has been applied to the pharmaceutical field with excipient studies and DNA drugs. In recent times, more attention has been applied to lipid-based drug delivery systems and drug interactions with biomimetic membranes. Highly reproducible phase transitions have been used to determine values, such as, the type of binding interaction, purity, stability, and release from a drug delivery mechanism. This review focuses on the use of DSC for biochemical and pharmaceutical applications.


How to cite this article:
Chiu MH, Prenner EJ. Differential scanning calorimetry: An invaluable tool for a detailed thermodynamic characterization of macromolecules and their interactions.J Pharm Bioall Sci 2011;3:39-59


How to cite this URL:
Chiu MH, Prenner EJ. Differential scanning calorimetry: An invaluable tool for a detailed thermodynamic characterization of macromolecules and their interactions. J Pharm Bioall Sci [serial online] 2011 [cited 2022 May 20 ];3:39-59
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2011;volume=3;issue=1;spage=39;epage=59;aulast=Chiu;type=0