Journal of Pharmacy And Bioallied Sciences

: 2021  |  Volume : 13  |  Issue : 4  |  Page : 352--359

Thyroid function assessment in Saudi males with metabolic syndrome

Fahad Khalid Aldhafiri1, Fathy Elsayed Abdelgawad2, Gihan Mohamed Mohamed Bakri3, Tamer Saber4 
1 Department of Public Health, College of Applied Medical Sciences, Majmaah University, Al Majmaah, Saudi Arabia
2 Medical Biochemistry Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, KSA
3 University Medical Center, Islamic University of Madinah, Madinah, KSA
4 Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Correspondence Address:
Dr. Fahad Khalid Aldhafiri
Public Health Department, Applied Medical Sciences College, Majmaah University Saudi Arabia, Industrial Area, Al Majma'ah 15341
Saudi Arabia

Background: Metabolic Syndrome (MetS) is a multifactor condition associated with cardiovascular risk. Thyroid hormones regulate MetS components via controlling energy homeostasis, lipids, and glucose metabolism. The risk ratio for MetS and related disorders changes between males and females. Aim and Objectives: Study aim to access thyroid functions in Saudi population with metabolic syndrome. Materials and Methods: The current study sought to evaluate the impact of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) in predicting the risk of MetS. A total of 200 (MetS 100 and control 100) Saudi Arabian males were enrolled for the study, and after applying eligibility criteria, the eligible study size was examined for the physical test (chest, abdominal, and general examination with stress on blood pressure measurement) and anthropometric parameters (bodyweight, body mass index, and waist circumference). Results: In the present study, the biochemical parameters, such as TSH, FT3, FT4, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), high-density lipoprotein (LDL), fasting glucose, and fasting insulin were measured in the study group, and statistical analysis was also performed. The results revealed that the MetS and control differ in terms of physical, anthropometric, and biochemical markers. The study showed that thyroid dysfunction (TD) and MetS are closely associated with the difference in physical, anthropometric, and metabolic characteristics. Conclusion: The result demonstrated hypothyroidism major risk factor due to TD in MetS. These findings provide a scientific basis for diagnosis and the management of TD, associated MetS, and cardiovascular disease (CVD).

How to cite this article:
Aldhafiri FK, Abdelgawad FE, Bakri GM, Saber T. Thyroid function assessment in Saudi males with metabolic syndrome.J Pharm Bioall Sci 2021;13:352-359

How to cite this URL:
Aldhafiri FK, Abdelgawad FE, Bakri GM, Saber T. Thyroid function assessment in Saudi males with metabolic syndrome. J Pharm Bioall Sci [serial online] 2021 [cited 2022 May 23 ];13:352-359
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