Journal of Pharmacy And Bioallied Sciences

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 13  |  Issue : 5  |  Page : 510--515

The effects of double antibiotic paste and amoxicillin-clavulanate paste used in endodontic regeneration on microhardness of radicular dentine: An In vitro study


Meenu Madhukumar1, Praveena Geetha1, K Radhakrishnan Nair1, Manu Unnikrishnan2 
1 Department of Conservative Dentistry and Endodontics, Azeezia College of Dental Science and Research, Kollam, Kerala, India
2 Department of Conservative Dentistry and Endodontics, Chettinad Dental College and Research Institute, Kanchipuram, Tamil Nadu, India

Correspondence Address:
Meenu Madhukumar
Azeezia College of Dental Science and Research, Kollam, Kerala
India

Objective: Double antibiotic paste is a root canal medicament used in regenerative endodontics and its long-term exposure to dental hard tissues was shown to reduce its mechanical properties. The amoxicillin-clavulanate paste is a medicament effective against endodontic pathogens and is effective in endodontic regeneration. Its effect on radicular dentine is yet to be investigated. The purpose of this study is to investigate and compare the effects of double antibiotic paste and amoxicillin-clavulanate paste on the microhardness of radicular dentine. Materials and Methods: The root canal of 45 premolars was mechanically prepared and divided into three groups for the placement of intracanal medicament: Group 1 (n = 15) double antibiotic paste, Group 2 (n = 15) amoxicillin-clavulanate paste, and Group 3 control group (n = 15). All the specimens were subject to microhardness testing at 500 and 1000 microns depth for 1 week, 1 month, and 3 months and analyzed. Results: There is no significant reduction in microhardness of radicular dentin at 1 week on all the three groups. At 1 month and 3 month period, the amoxicillin-clavulanate paste is found to have no significant effect on dentin microhardness when compared to double antibiotic paste. Conclusion: The use of amoxicillin-clavulanate paste as an intracanal medicament does not cause significant weakening of dentin even after its long-term use.


How to cite this article:
Madhukumar M, Geetha P, Nair K R, Unnikrishnan M. The effects of double antibiotic paste and amoxicillin-clavulanate paste used in endodontic regeneration on microhardness of radicular dentine: An In vitro study.J Pharm Bioall Sci 2021;13:510-515


How to cite this URL:
Madhukumar M, Geetha P, Nair K R, Unnikrishnan M. The effects of double antibiotic paste and amoxicillin-clavulanate paste used in endodontic regeneration on microhardness of radicular dentine: An In vitro study. J Pharm Bioall Sci [serial online] 2021 [cited 2023 Jan 31 ];13:510-515
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=5;spage=510;epage=515;aulast=Madhukumar;type=0