Journal of Pharmacy And Bioallied Sciences

REVIEW ARTICLE
Year
: 2022  |  Volume : 14  |  Issue : 3  |  Page : 121--125

Meloxicam in combating clinical mastitis: Nanotechnology-driven hope and opportunities


Vaskuri G S Satya Sainaga Jyothi1, Chanti Katta Babu1, Rahul Kumar2, Pankaj Kumar Singh1, Dharmendra Kumar Khatri2, Shashi Bala Singh2, Jitender Madan1 
1 Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India
2 Department of Biological Sciences, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India

Correspondence Address:
Dr. Jitender Madan
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana
India

Mastitis has well-recognized harmful effects on dairy farm profitability. Furthermore, mastitis impairs the milk component synthesizing ability of secretary tissues. Various therapies are available for the treatment of clinical mastitis. Meloxicam exhibits preferential binding to Cyclooxygenase-2 (COX-2) receptor and consequently generates fewer negative gastrointestinal side effects than nonspecific COX inhibitors such as flunixin meglumine and ketoprofen. Toward this end, research efforts directed at understanding the use of meloxicam alone and in combination with other antibiotics to improve milk quality and production. Therefore, in this review, we have highlighted the mechanism, biopharmaceutical challenges, and merits of meloxicam usage in dairy cattle mastitis. In addition, we also presented the integration of artificial neural network, in silico docking, and nanotechnology-driven topical drug delivery cargo as future opportunity for efficient delivery of meloxicam in the management of clinical mastitis.


How to cite this article:
Jyothi VG, Babu CK, Kumar R, Singh PK, Khatri DK, Singh SB, Madan J. Meloxicam in combating clinical mastitis: Nanotechnology-driven hope and opportunities.J Pharm Bioall Sci 2022;14:121-125


How to cite this URL:
Jyothi VG, Babu CK, Kumar R, Singh PK, Khatri DK, Singh SB, Madan J. Meloxicam in combating clinical mastitis: Nanotechnology-driven hope and opportunities. J Pharm Bioall Sci [serial online] 2022 [cited 2022 Oct 1 ];14:121-125
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2022;volume=14;issue=3;spage=121;epage=125;aulast=Jyothi;type=0