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  Indian J Med Microbiol
 

Figure 5 :Panel A. Calorimetric curves during the permeation kinetic of a drug released from a delivery system through multi-lamellar vesicles. The arrows mark the position of the multi-lamellar vesicles at t = 0. Adapted from Raudino et al.[27] Panel B. Schematic representation of what happens in the calorimetric pan. In (a) the drug is not released from the delivery system and the calorimetric curve remains unchanged. In (b), initially, the drug is released from the delivery system and transferred to the external bilayers of MLV and a double peak is observed in the calorimetric curve; as the time passes the drug localized also in the internal bilayers and a unique peak is observed in the calorimetric curve. In (c) the drug released from the delivery system quickly localizes uniformly in all the bilayers and a unique peak is observed from the first times of contact

Figure 5 :Panel A. Calorimetric curves during the permeation kinetic of a drug released from a delivery system through multi-lamellar vesicles. The arrows mark the position of the multi-lamellar vesicles at t = 0. Adapted from Raudino et al.[27] Panel B. Schematic representation of what happens in the calorimetric pan. In (a) the drug is not released from the delivery system and the calorimetric curve remains unchanged. In (b), initially, the drug is released from the delivery system and transferred to the external bilayers of MLV and a double peak is observed in the calorimetric curve; as the time passes the drug localized also in the internal bilayers and a unique peak is observed in the calorimetric curve. In (c) the drug released from the delivery system quickly localizes uniformly in all the bilayers and a unique peak is observed from the first times of contact