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  Indian J Med Microbiol
 

Figure 7 :Left part. Calorimetric curves of unloaded MLV (X=0) (which represent the biomembrane model) put in contact with an equimolar amount of loaded MLV (X=n) (which represent the lipophilic carrier), at increasing time of incubation. Right part. Schematic representation of what happens in the calorimetric pan. The calorimetric curves identified as X=n/2 is used as reference and it should be obtained in the case the drug transfers from loaded to unloaded MLV till to have the same concentration in all the MLV which has a mean value among the concentrations of the MLV which were put in contact. (a) The drug does not transfer from loaded MLV to unloaded MLV and the reference curve is never reached; (b) At the beginning the drug does not transfer from loaded to unloaded MLV; as the incubation time passes the drug transfers till its concentration will be the same if all the MLV and the reference curve is reached. (c) The drug quickly transfers from loaded to unloaded MLV and the reference curve is reached

Figure 7 :Left part. Calorimetric curves of unloaded MLV (X=0) (which represent the biomembrane model) put in contact with an equimolar amount of loaded MLV (X=n) (which represent the lipophilic carrier), at increasing time of incubation. Right part. Schematic representation of what happens in the calorimetric pan. The calorimetric curves identified as X=n/2 is used as reference and it should be obtained in the case the drug transfers from loaded to unloaded MLV till to have the same concentration in all the MLV which has a mean value among the concentrations of the MLV which were put in contact. (a) The drug does not transfer from loaded MLV to unloaded MLV and the reference curve is never reached; (b) At the beginning the drug does not transfer from loaded to unloaded MLV; as the incubation time passes the drug transfers till its concentration will be the same if all the MLV and the reference curve is reached. (c) The drug quickly transfers from loaded to unloaded MLV and the reference curve is reached