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Figure 8: Effect of XAE (300 mg kg- 1), XA (100 mg kg-1) and morphine (MOR; 3 mg kg-1) challenge on mice chronically treated with vehicle, XAE (600 mg kg- 1), XA (200 mg kg- 1) or morphine (6 mg kg- 1) for 8 days on the total nociceptive score in Phase 1 (a) and Phase 2 (b) of formalin-induced pain in mice. Each column represent the mean ± S.E.M. (n = 8); *P < 0.05, **P < 0.01, ***P < 0.001 compared to vehicle-treated control group (ctrl) (one-way ANOVA followed by Newman-Keuls post hoc test) |
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